ResearchMy laboratory studies the molecular pathogenetic features of bacteria causing chronic diarrhea in the developing world. This work entails the application of sophisticated molecular genetic techniques to characterize bacterial virulence factors and mechanisms. The ultimate aim of this research is to develop efficient and cost effective interventions against diarrheal diseases, including vaccines. My laboratory works closely with epidemiologic, clinical and volunteer studies so that laboratory developments can be rapidly implemented in relevant situations.
PublicationsBehrens, M., J. Sheikh, J.P. Nataro. Regulation of the Overlapping pic/set Locus in Shigella flexneri and Enteroaggrtegative Escherichia coli. Infect. Immuno. 2002 70:2915-25.
Sheikh, J., S. Hicks, M. Dall’Agnol, A.D. Phillips, J.P. Nataro. Roles for Fis and YafK in biofilm formation by enteroaggregative Escherichia coli. 2001, 41:983-97.
Henderson, I.R., J. Czeczulin, C. Eslava, F. Noriega, J.P. Nataro. Characterization of pic, a secreted protease of Shigella flexneri and enteroaggregative Escherichia coli. Infect Immun 1999 Nov; 67(11):5587-96.
Henderson, I.R., S. Hicks, F. Navarro-Garcia, W.P. Elias, A.D. Philips, J.P. Nataro. Involvement of the enteroaggregative Escherichia coli plasmid-encoded toxin in causing human intestinal damage. Infect Immun 1999 Oct; 67(10):5338-44.
Elias, Jr., W.P., J.R. Czeczulin, I.R. Henderson, L.R. Trabulsi, J.P. Nataro. Organization of biogenesis genes for aggregative adherence fimbria II defines a virulence gene cluster in enteroaggregative Escherichia coli. J. Bacteriol 1999 Mar; 181(6):1779-85.
Henderson, I.R., P. Owen, J.P. Nataro. Molecular switches--the ON and OFF of bacterial phase variation. Mol Microbiol. 1999 Sep; 33(5):919-32.
Eslava, C., F. Navarro-Garcia, J.R. Czeczulin, I.R. Henderson, A. Cravioto, J.P. Nataro. Pet, an autotransporter enterotoxin from enteroaggregative Escherichia coli. Infect Immun. 1998 Jul; 66(7):3155-63.
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