search
Advanced Search
Skip navigation links
OverviewExpand Overview
Faculty
ProgramsExpand Programs
Core Facilities and Shared ResourcesExpand Core Facilities and Shared Resources
CurriculumExpand Curriculum
Student LifeExpand Student Life
Seminars & EventsExpand Seminars & Events
NIH Sponsored Training Programs
News
Inquire Online
Apply Online
Postdoctoral NetworkExpand Postdoctoral Network
Contact Us
Home
 
Ronald Gartenhaus, M.D.
Associate Professor

Department of Medicine


410-328-3691

rgartenhaus@som.umaryland.edu

Research

The major focus of my laboratory research efforts is studying mechanisms of lymphomagenesis. We are examining the role of the  MCT-1 oncogene and how it participates in the translational machinery. Using a transagenic mouse engineered to overexpress the MCT-1 oncogene, we are establishing an in vivo lymphoma model in order to develop more effective and targeted therapies.

I am also interested in developing novel therapeutic strategies in CLL and related lympho-proliferative disorders



Publications

Shi B, Hsu HL, Evens AM, Gordon LI, and Gartenhaus RB. Expression of the candidate MCT-1 oncogene in B-and T-cell lymphoid malignancies. Blood, 102:297-302, 2003.

Frankel AE, Fleming DR, Hall PD, Powell BL, Black JH, Leftwich C, and Gartenhaus R. A phase I study of DT fusion protein denileukin diftitox in patients with fludarabine refractory chronic lymphocytic leukemia. Clinical Cancer Research, 9(10):3555-61, 2003.   

Nasedkina TV, Zharinov VS, Isaeva EA, Yurasov R, Turigin AY, Karachunskii AI, Gartenhaus RB*, Mirzabekov AD. Clinical screening of gene rearrangements in childhood leukemia by multiplex PCR-microarray approach. Clinical Cancer Research, 9(10):5620-29, 2003. (*corresponding author).

Shi B, Levenson V, and Gartenhaus RB. Identification and characterization of a novel enhancer for the human MCT-1 oncogene promoter. Journal of Cellular Biochemistry, 90(1):68-79, 2003.  

Evens AE, Gordon LI, Prachand S, Paniaqua M, Shi B and Gartenhaus RB. Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent. Clinical Cancer Research, 10:1481-91, 2004.         

Melnikov, Anatoliy A., Gartenhaus, Ronald B., Levenson, Anait S , Motchoulskaya,,Natalia A., Levenson (Chernokhvostov), Victor, V.: Multiplexed Analysis of Gene-Specific DNA Methylation. Nucleic Acids Research 33(10):e93, 2005.

Andrew M. Evens, Philip Lecane, Sheila Prachand, Seema Singhal, Mary Paniaqua, Darren Magda, Richard Miller, Ronald B. Gartenhaus*, and Leo I. Gordon: Motexafin Gadolinium Generates Reactive Oxygen Species and Induces Apoptosis in Multiple Myeloma Cell Lines. Blood 105:1265–73, 2005 (*corresponding author).   

Hsin-Ling Hsu, Bo Shi, and Ronald B. Gartenhaus: The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. Oncogene 24(31):4956-64, 2005.         

Levenson A.S., Thurn T.E., Simons L.A., Osipo C., Jordan V.C., Volpert O.V., Satcher R.L., Gartenhaus R.B.: MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells through promotion of angiogenesis and inhibition of apoptosis. Cancer Research 65(23):10651-6, 2005.

Ali Hachem and Ronald B. Gartenhaus. Oncogenes as Molecular Targets in Lymphoma. Blood, 106: 1911-1923, 2005.

Suvobroto Nandi, Jeanette Yu, Angelika M. Burger, Line S. Reinert and Ronald B. Gartenhaus: Expression of DNA Mismatch Repair Proteins in Transformed non-Hodgkin’s Lymphoma: Relationship to Smoking. Leukemia and Lymphoma 47(9):1806-12, 2006.    

Line Sinnathamby, Suvobroto Nandi, Bo Shi, Helen Hui and Ronald B, Gartenhaus: MCT-1 Protein Interacts with the Cap Complex and modulates mRNA Translational Profiles. Cancer Research 66(18):8994-9001, 2006.

S Nandi, L S. Reinert, A Hachem, K Mazan-Mamczarz, P Hagner, H He and R B. Gartenhaus: Phosphorylation of MCT-1 by p42/44 MAPK is required for its stabilization in response to DNA damage. Oncogene Apr 5;26(16):2283-9, 2007.    

Krystyna Mazan-Mamczarz and Ronald B Gartenhaus: Translational control of the MCT-1 associated protein DENR/DRP by RNA-binding protein AUF1. Cancer Genomics & Proteomics 4: 233-240, 2007. 

Hsin-Ling Hsu, Chik On Choy, Jeffrey R. Sawyer, Ravi Kasiappan, Chung-Li Shu, Yi-Rong Chen, Hsin-Fen Hsu, Ronald B. Gartenhaus: MCT-1 oncogene down-regulates p53 activity and destabilizes genome structure in response to DNA damage. DNA Repair 1;6(9):1319-32, 2007.   

Krystyna Mazan-Mamczarz, Patrick R. Hagner, William H. Wood, Yongqing Zhang, Kevin G. Becker, Zhenqui Liu and Ronald B. Gartenhaus: Identification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach. Cancer Res. Oct 1;68(19):7730-5, 2008.

Zhenqui Liu, Ronald B Gartenhaus, Ming Tan and Xiaoli Jiao: Gene and Pathway Identification with Lp Regularized Bayesian Logistic Regression. BMC Bioinformatics. Oct 3;9:412, 2008.

Krystyna Mazan-Mamczarz, Patrick R. Hagner, Sharon Corl, William H. Wood, Kevin G. Becker, Myriam Gorospe, Jack D. Keene, Anait S. Levenson and Ronald B. Gartenhaus: Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene, Oct 16;27(47):6151-63, 2008.

Krystyna Mazan-Mamczarz, Patrick Hagner, Bojie Dai, Sharon Corl, Zhenqui Liu and Ron B. Gartenhaus: Targeted Suppression of MCT-1 Attenuates the Malignant Phenotype Through a Translational Mechanism. Leuk Res. Mar;33(3):474-82, 2009.

Patrick Hagner, Krystyna Mazan-Mamczarz, Bojie Dai, Sharon Corl, X. Frank Zhao and Ronald B. Gartenhaus: Alcohol Consumption and Decreased Risk of NHL: Role of mTOR Dysfunction. Blood In press 2009.

Back to All Faculty



School of Medicine | Dental School | Graduate School | University of Maryland, Baltimore
Center of Marine Biotechnology (COMB) | Medical Biotechnology Center (MBC)

Please read the disclaimer concerning use of this University of Maryland School of Medicine site.

® University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore MD 21201
site maintained by moderntymes.com