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2016 Cancer Biology T-32 Training Grant

For more information Contact:  

 Marcina Garner, Program Manager

 University of Maryland School of Medicine
800 W. Baltimore Street, Room 216
Baltimore, MD 21201
Phone 410-706-8114; Fax 410-706-8121

Yan Sun, Program Administrator  

Center for Vascular & Inflammatory Diseases
800 W. Baltimore Street, Room 212
Baltimore, MD  21201
410-706-8028;
410-706-8121 (fax)  

Toni M. Antalis, Ph.D., Co-Director
Professor of Physiology,
University of Maryland School of Medicine
410 706 8222

Curt I. Civin, M.D., Co-Director
Associate Dean for Research,
University of Maryland School of Medicine
410-706-1198/1181

Download 2016 Guidelines and Application

PENDING 

Overview

The Cancer Biology T32 Training Program at the University of Maryland is a prestigious program designed to train predoctoral students and postdoctoral fellows in fundamental mechanisms of cancer biology at the molecular, cellular and organism levels.  The program takes advantage of the multidisciplinary and highly interactive research environment within the University of Maryland Greenebaum Cancer Center and at the University of Maryland Baltimore campus to provide outstanding training in critical areas of basic and translational cancer research. A guiding philosophy is that Cancer Biology T32 training program must provide integrative activities that illuminate the inter-relatedness of basic cancer research and clinical medicine.  Support for the program has been provided from a training grant from the NIH National Cancer Institute.

Major advances in our understanding the complexity of cancer and tumor cell biology requires a quantitative understanding of the many interconnected networks of molecules that comprise our cells and tissues, their interactions, and their regulation.  A collective strength of the investigators of this training program is the integration of multiple, diverse disciplines that encompass experimental approaches and didactic knowledge from biochemistry, cell biology, epidemiology, genetics, immunology, microbiology, pharmacology, molecular biology, pathology, and physiology, in addition to the clinical oncologic sciences that are involved in human cancer prevention, detection, diagnosis, and treatment. The goal of Cancer Biology training program is to provide an integrative research experience with appropriate mentoring and career guidance to facilitate the inter-relatedness of basic cancer research and clinical medicine. The T32 Cancer Biology program is designed to meet this objective through appropriate didactic and research components, interactive seminars and workshops, and professional development that should provide a solid foundation for a long term and successful career in cancer research.

The T32 Cancer Biology Training Program has positions for predoctoral students, postdoctoral fellows and for residents and clinical fellows interested in cancer research.

To be considered for a position on this training grant, a faculty mentor will be identified and a research plan will be developed in conjunction with the mentor.

The award of a trainee slot on this grant is for a 1 year period, and is renewable by competitive application for a 2nd and possibly a 3rd year, however each year involves a competitive renewal with no greater assurance of funding for ongoing applicants than for new applicants. Trainees and mentors are strongly encouraged to apply for individual competitive fellowships or for other cancer research grant support during their 1st or 2nd year in the program. All predoctoral and postdoctoral fellows supported by the Cancer Biology T32 training program will be encouraged to participate in didactic components, interactive seminars and workshops, and professional development to appropriate to their background, in order to provide a solid foundation for a long term and successful career in cancer research. 

Funding support from this grant is limited to the levels mandated by NIH guidelines. Salary may be supplemented from other single or combined sources, such as research grants, professional fees, etc. Health insurance and support for travel is provided. For M.D. trainees, support from the T32 Training Program provides ‘protected time’ for immersion in the laboratory and it is required that patient care responsibilities will be limited to <10% effort (one half day per week), primarily to help complete long-term patient care experience necessary for their subspecialities and to maintain patient-care skills. 

Qualifications for Trainee Slots:

  • All appointments to this training grant are restricted to U.S. citizens and permanent residents.
  • Applicants must be committed to cancer research.
  • Predoctoral applicants must be enrolled in GPILS (PhD or MD/PhD program) at the University of Maryland Baltimore.  Students must have completed the required courses: GPLS 790 - Advanced Cancer Biology and GPLS 665 - Cancer Biology: From Basic Research to the Clinic.
  • Postdoctoral applicants must have completed doctoral level training (e.g. PhD, MD, MD/PhD, PharmD, DDS or equivalent).  Evidence of scholarly productivity in the form of publications or planned publications is highly desirable.  Post-doctoral trainees from Residency and Fellowship training programs (e.g. Radiation Oncology, Hematology/Oncology, and Oncology residents from OB-GYN, Otorhinolaryngology, Pathology, Pediatrics, Medicine or Surgery residency programs) are encouraged to apply. 

 

Download 2016 Guidelines and Application

 

PENDING 

 

Faculty Mentors

Name/Degree(s)  
Research Focus  

Adebamowo, Clement A.
MD Sc.D.
  email icon 

The molecular biology of HPV associated cancer (cervical and head and neck cancer) and breast cancer, identification of new genomics and epigenomics biomarkers of cervical cancer. Cancer registration and epidemiology. Breast cancer epidemiology – genetics, epigenetics and gut microbiomics determinants of hormone receptor specific types of breast cancer

Antalis, Toni, Ph.D.email icon  Regulation of signaling pathways affecting cancer growth and metastasis, vascular biology, angiogenesis, and inflammation by serine proteases and their inhibitors.

Antony, Paul Andrew, M.D.email icon 

To develop therapies that use the immune system to fight cancer, with an emphasis on 1) adoptive immunotherapy of cancer using tumor-specific CD4 T cells or tumor-specific CD8+ T cells and 2) the use of cytokine therapies especially IL-15 and cytokine antibody immune complexes.

Baer, Maria, M.D.email icon 

Signaling pathways affecting drug resistance mechanisms in acute myeloid leukemia

Banerjee, Arnob MD, PhD email icon 

Molecular mechanisms governing gene expression patterns and differentiation in T lymphocytes both in the setting of anti-cancer immune responses and in the setting of T cell leukemia and lymphoma

Bentzen, Soren Ph.D.email icon   Biostatistical methodology for the design and analysis of cancer combination studies; adaptive clinical trial designs, risk and prognostic modeling, regularized regression models for genomic and proteomic data, statistical analysis for the evaluation of accuracy of diagnostic tests and cancer biomarkers and epidemiology including hierarchical modeling in cancer control studies.

Brodie, Angela Ph.D.email icon 

Internationally recognized for her pioneering work on the development of aromatase inhibitors as a treatment for breast cancers.

  Bromberg, Jonathan S M.D.  The immunology of chemokines and cell migration on the immune response; regulation of the T cell response in immunosuppression and cancer therapy 

Carey, Gregory, Ph.D.email icon 

Regulation of signal protein activity and fate by reactive oxygen species (ROS); mechanisms of action of natural, synthetic and biological anti-tumor agents.

Carrier, France, Ph.D.email icon 

DNA damage response, activation of RNA binding proteins, Histone deacetylase Inhibitors, Translational research, tumor suppressor genes (p53).

Civin, Curt, M.D.email icon 

Cell and molecular biology of normal hematopoiesis and leukemia

Cullen, Kevin J., M.D.email icon 

Molecular markers of treatment response and outcome in head and neck cancer

Davila, Eduardo, PhD email icon
 

Exploiting TLR signaling in T cells for enhanced anti-tumor activity; pattern recognition receptors and T-cell leukemia progression

Devine, Scott, Ph.D.email icon 

Human genetic variation caused by transposable genetic elements and small insertions/deletions (INDELs)

Donnenberg, Michael, M.D. email icon 

Molecular Pathogenesis of E. coli infections; Role of E. coli in colorectal carcinogenesis.

Dorgan, Joanne PhD email icon 

Identifying hormonal determinants of cancer, particularly breast cancer, and hormonal mechanisms by which environmental and behavioral exposures, as well as genetics, affect cancer risk

Dorsey, Susan G., Ph.D.email icon 

The molecular, cellular and genetic correlates of the development and persistence of cancer-treatment related chronic pain.

Eckert, Richard, Ph.D.email icon 

MAPK signaling and transcriptional control of gene expression

Fraser-Liggett, Claire, Ph.D.email icon 

The role of human gut microbial communities in health and various diseases including obesity, inflammatory bowel disease, and colon cancer.

Fulton, Amy, Ph.D.email icon 

Biologic determinants of cancer metastasis; biologic basis of cancer disparities; role of cyclooxygenase pathway in tumor biology; role of chemokine receptors in tumor biology

  Gallo, Robert  C. M.D.  HIV biology and vaccine development

Gartenhaus, Ron, M.D.email icon 

The biology of the MEK/ERK pathway vis-à-vis its role in regulating the MCT-1 oncogene and how they contribute to lymphomagenesis.

Garzino-Demo, Alfredo  Ph.D.  Molecular virology; role of the immune system and host factors in controlling HIV infection. HIV proteins in murine models of lymphomagenesis

Hassel, Bret A., Ph.D.email icon 

Molecular mechanisms of antiproliferative activities by the tumor suppressor RNase-L. Posttranscriptional regulation of mRNA turnover, and alteration of this control in tumor cells.

Jewell, Christopher, Ph.D. email icon 

Immune engineering; synthetic materials, nanotechnology

Kaetzel,  David Ph.D.
 
Molecular mechanisms underlying metastasis driving mutations in melanoma

Keegan, Achsah D., Ph.D.email icon 

Cytokine signaling, apoptosis, chemosensitivity, macrophage activation, allergic lung inflammation

Kim, Anthony., Ph.D. 

Translational neuro-oncology; integrating innovative biophysical techniques and advanced therapeutic delivery platforms with brain cancer biology to solve clinical problems and improve patient outcomes.

Losert, Wolfgang Ph.D.  email icon  Department of Physics, University of Maryland College Park;  application of cutting-edge mathematical-physical principles of analysis to large-scale data for cancer research, diagnostics and therapeutics.

Lu, Wuyuan Ph.D.email icon 

Protein engineering via chemical protein synthesis; defensin structure, function and mechanisms of action; antiviral and antitumor peptides for targeted molecular therapy

MacKerell, Alexander D. Jr. Ph.D. email icon 

Force field development and computational studies of nucleic acids, proteins and carbohydrates

Mao, Li, M.D.email icon 

Molecular and genetic alterations and their roles in the multistep process of upper aerodigestive tract malignancies.

Martin, Stuart S., Ph.D. email icon 

Cytoskeletal and apoptotic determinants of circulating breast tumor cell survival and metastasis.

Njar, Vincent Ph.D. email icon  Rational discovery and development of small molecules as anti-cancer agents, with a focus on breast, prostate and pancreatic cancers
Olson, John MD, Ph.D. email icon  Development of biomarkers for breast cancer and aromatase inhibitor therapy
Ostrand-Rosenberg, Suzanne Ph.D.    Cancer-induced immune suppression; cancer immunotherapies; cancer vaccines; myeloid-derived suppressor cells (MDSC) and tumor associated macrophages (TAMS) as potent immune suppressors

Passaniti, Antonino, Ph.D.email icon 

Transcriptional regulation of tumor angiogenesis and breast cancer metastasis; metabolic function of vascular endothelial cells in obesity

Pauza, C. David, Ph.D.email icon 

Tumor immunity and immunotherapy, tumor recognition and killing by gd T cells, AIDS-related malignancies, oncogenic mechanisms for HIV, Hepatitis C Virus and Human Papillomavirus in immunodeficient patients.

Perrotti, Danilo MD PhD email icon  RNA metabolism and leukemia; biological decoy activity of microRNAs; activating tumor suppressor phosphatases to treat cancer

Qiu, Yun, Ph.D.email icon 

Molecular mechanisms underlying drug resistance in prostate cancer, specifically autocrine/paracrine factors that activate protein kinase cascades controlling antiapoptotic signaling to confer resistance to therapies.

Rassool, Feyruz V., Ph.D.email icon 

Production of reactive oxygen species (ROS), DNA damage and repair responses in leukemia leading to genomic instability and disease progression.

Raufman, Jean-Pierre, M.D. email icon 

Muscarinic receptors and ligands in colon cancer

Sarkar, Rajabrata, M.D. Ph.D.email icon 

Regulation of angiogenesis in vivo. Activation of p53 and mechanisms of p53 modulation of angiogenesis and arteriogenesis.

Sausville, Edward, M.D., Ph.D.email icon 

Molecular mechanisms of novel anti-neoplastic agent action, clinical studies of novel cancer therapies

Schneider, Abraham D.D.S, PhD  email icon  Use of antidiabetic biguanides, such as metformin, in oral cancer chemoprevention and treatment

Shapiro, Paul, Ph.D.  email icon 

Kinase signaling cascades and regulation of cell proliferation, development of small molecular weight compounds that selectively inhibit MAP kinase interactions with substrate proteins.

Snyder, Greg P.h.D.    Biophysical and biochemical characterization of the B-cell lymphoma mutation MyD88L265P; Toll-like and Interleukin -1 receptor antagonists against microbial pathogens and immunity.
Summers, Michael PhD email icon 

Structure and function of retroviral proteins and the viral genome, mechanism of structural protein assembly and packaging during virus intracellular movement

Vitolo, Michele Ph.D. email icon  Molecular mechanisms by which PTEN loss promotes metastatic efficiency of circulating tumor cells
Vujaskovic, Zeljko M.D., Ph.D. email icon  Mechanisms associated with radiation injury; use of radioprotectors and sensitizers in treating genitourinary and prostate cancers
Wang, Hongbing Ph.D. email icon  Nuclear receptor-mediated induction of drug-metabolizing enzymes and transporters, metabolism-based drug-drug interactions, and drug-induced liver toxicity.
Wang, Jian-Ying M.D. Ph.D   The roles and mechanisms of cellular polyamines and polyamine-regulated genes in the control of intestinal epithelial cell proliferation, apoptosis, migration, and cell-to-cell interactions.

Webb, Tonya, Ph.D.email icon 

Cancer immunology, specifically investigating mechanisms by which tumors evade immune detection as well developing novel immunotherapeutic strategies for the treatment of melanoma, breast and prostate cancers.

Weber, David J. , Ph.D.email icon 

Structure/function relationships of calcium-binding proteins and their biological targets, cancer biology, structural biology, drug design

Winkles, Jeffrey A., Ph.D.email icon 

Role of the TWEAK/Fn14 axis in tumor growth and metastasis.

Woodworth, Graeme F., M.D., B.S.email icon   Translational neuro-oncology with a research focus on delivering effective therapeutics to brain-invading, unresectable glioblastoma cancer cells.

Zhan, Steven, Ph.D.email icon 

Cell motility, tumor invasion, metastasis, cell biology, genome instability, angiogenesis, and tyrosine kinase signaling pathways.

Zhang, Li, Ph.D.email icon 

Myeloid-derived suppressor cells in tumor growth and metastasis.

Zhou, Qun M.D. Ph.D.   The roles of microRNAs (miRNAs) in breast cancer stem cells and malignant transformation