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Cell Biology

cell bio 

Cell biology research in the program encompasses a broad range of studies that overlap in some cases with the other disciplines of the program. For example the work of Dr. Schulze studies modifications to antibodies that enhance Fc receptor binding and their function which includes tumor cell lysis.  Dr. Feldman is modeling inherited diseases by reprogramming patient-derived somatic cells into induced pluripotent stem (iPS) cells.  Dr. Kalvakolanu studies signal transduction (JAK/STAT and non-STAT) and gene regulatory pathways regulated by the Interferons. This lab also studies mechanisms of action of tumor suppressors, transcriptional control, and their roles in apoptosis (programmed cell death) and autophagy.  Also part of this group, Dr. Hassel studies the mechanism of action of type 1 interferons in host innate immune response to microbial pathogens and tumors. His work focuses on RNase-L, the terminal component of an RNA decay pathway that mediates antimicrobial and tumor suppressor activities.  Dr. Robb studies stress regulation in live bacterial vaccines and protein folding systems.  Dr. Vasta studies innate immune recognition and effector mechanisms that are mediated by protein-carbohydrate interactions. 

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Alumni Highlights

Research Spotlight:

UM SOM Researchers Unravel Mechanism That Plays Key Role in Sexual Differentiation of Brain

McCarthyDuring prenatal development, the brains of most animals, including humans, develop specifically male or female characteristics. In most species, some portions of male and female brains are a different size, and often have a different number of neurons and synapses. However, scientists have known little about the details of how this differentiation occurs. Now, a new study by researchers at the University of Maryland School of Medicine (UM SOM) has illuminated some details about how this occurs.‌

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