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Microbial Genomics

 Microbial Genomics

The tools of bioinformatics and microbial genomics are applied to a diverse set of organisms by an outstanding group of molecular biologists within the program, including Drs. Carneiro Da Silva, DasSarma, Fraser, Dunning-Hotopp, Rasko, Ravel and Tettelin. Their work is focused on a variety of pathogenic and non-pathogenic microbial organisms, their interplay and the environments in which they reside. Organisms studied include Escherichia coli, Shigella, Chlamydia, halophilic archaea, Streptococcus, Neisseria, Wolbachia, and members of the eukaryotic Apicomplexa. 

Drs. Fraser, Rasko, Ravel and Tettelin utilize genomic approaches to study human microbiomes in health and disease (including those found in the gut, lung and vaginal cavities), to explore population genomics of bacterial pathogens, and to identify possible novel vaccine antigens. Dr. Fraser is the Director of the Institute for Genome Sciences (IGS), a genome research center on the UMB campus and Drs. Carneiro da Silva, Dunning-Hotopp, Rasko, Ravel and Tettelin are all research scientists at IGS.

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Research Spotlight:

UM SOM Researchers Unravel Mechanism That Plays Key Role in Sexual Differentiation of Brain

McCarthyDuring prenatal development, the brains of most animals, including humans, develop specifically male or female characteristics. In most species, some portions of male and female brains are a different size, and often have a different number of neurons and synapses. However, scientists have known little about the details of how this differentiation occurs. Now, a new study by researchers at the University of Maryland School of Medicine (UM SOM) has illuminated some details about how this occurs.‌

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