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Cancer Biology

WINKLES_JEFF

Track Leader

Jeffrey A. Winkles, PhD
800 West Baltimore St.
Biopark Building 1, #320
(410) 706-8172
(410) 706-8234 (fax)
jwinkles@som.umaryland.edu

Overview

The Cancer Biology research track offers an exciting and stimulating academic environment in which to pursue interdisciplinary cancer research utilizing cutting edge technologies. Our students strive to make profound basic science discoveries that will lead to the next generation of sensitive diagnostics and specific therapeutics.

The primary objective of the Cancer Biology graduate track is to provide students with a strong educational experience combined with modern research training that will enable them to make significant contributions to the understanding of this complex disease. The curriculum is designed to provide a broad understanding of the molecular, genetic, cell biological and pathobiological aspects of cancer, in addition to a grasp of the current state of clinical cancer diagnosis and treatment. Built into the program are mechanisms to ensure that our graduates are effective communicators, good public speakers and writers. A Cancer Biology Research Retreat is held annually. This forum provides an opportunity for graduate students, postdoctoral and clinical research fellows, young investigators and faculty involved in cancer research to interact and share research ideas and techniques in an informal and relaxed environment.

The University of Maryland Marlene and Stewart Greenebaum Cancer Center, its core facilities, researchers and physicians provide a state-of-the-art environment for conducting both basic and clinical cancer research.

Potential and current Cancer Biology Track students should also visit our Cancer Biology T-32 Training Program web page.

Please feel free to contact the director of this track with any questions that you might have.

Areas of Research

Cancer is a complex disease with multiple steps in its pathogenesis and variability depending on the tissue of origin. Our understanding of cancer has reached new heights with the discovery of fundamental aspects of cell and molecular biology combined with advances in our understanding of the process of tumorigenesis. Discoveries in the identification of oncogenes and tumor suppressor genes, pathways of DNA damage and repair, cell cycle regulation, growth regulatory factors and cytokines, and the development of anti-angiogenic therapies have provided exciting new insights into the basic biology of cancers and new ways to fight cancer. Technological advancements in genomics, proteomics, and tissue arrays have refined cancer diagnosis, leading to the development of successful cancer chemotherapies and immunotherapies based on the knowledge of specific molecular targets.

Research Focus Areas Include:

  • Breast cancer
  • Prostate cancer
  • Leukemia & lymphoma
  • Radiation-induced cancers
  • Cytokine & growth factor biology
  • Hormonal control of tumor growth
  • Molecular & structural biology
  • Mechanisms of signal transduction
 
  • DNA replication, damage & repair
  • Carcinogenesis
  • Tumor suppressor genes
  • Genome instability & genetic mutations
  • Cancer genetics
  • Apoptotic cell death
  • Tumor invasion & metastasis
  • Proteases & tumor biology
  • Cytoskeleton & cell motility
  • Viral & cellular oncogenes
 
  • Tumor Angiogenesis & Inflammation
  • Cancer drug resistance
  • Cancer stem cells
  • Tumor immunology & immunotherapy
  • Diagnostic & prognostic markers
  • Experimental therapeutics
 

Note: this list is not an all inclusive list of the research being conducted.