2022 Publications

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Biochemistry & Molecular Biology

Epidemiology & Human Genetics

Gerontology

Molecular Medicine

Molecular Microbiology & Immunology

Neuroscience

Physical Rehabilitation Science

Biochemistry & Molecular Biology

Emmanuel Asiedu

Reader JC, Fan C, Ory EC, Ju J, Lee R, Vitolo MI, Smith P, Wu S, Ching MMN, Asiedu EB, Jewell CM, Rao GG, Fulton A, Webb TJ, Yang P, Santin AD, Huang HC, Martin SS, Roque DM. Microtentacle Formation in Ovarian Carcinoma. Cancers (Basel). 2022 Feb 4;14(3):800. doi: 10.3390/cancers14030800.

Hugo Bibollet

Morgenstern TJ, Nirwan N, Hernández-Ochoa EO, Bibollet H, Choudhury P, Laloudakis YD, Ben Johny M, Bannister RA, Schneider MF, Minor DL Jr, Colecraft HM. Selective posttranslational inhibition of Ca_Vβ₁-associated voltage-dependent calcium channels with a functionalized nanobody. Nat Commun. 2022 Dec 9;13(1):7556. doi: 10.1038/s41467-022-35025-7.

Ming-Wen Chang

Chang MW, Yang JH, Tsitsipatis D, Yang X, Martindale JL, Munk R, Pandey PR, Banskota N, Romero B, Batish M, Piao Y, Mazan-Mamczarz K, De S, Abdelmohsen K, Wilson GM, Gorospe M. Enhanced myogenesis through lncFAM-mediated recruitment of HNRNPL to the MYBPC2 promoter. Nucleic Acids Res. 2022 Dec 9;50(22):13026-13044. doi: 10.1093/nar/gkac1174.

Yang JH, Chang MW, Tsitsipatis D, Yang X, Martindale JL, Munk R, Cheng A, Izydore E, Pandey PR, Piao Y, Mazan-Mamczarz K, De S, Abdelmohsen K, Gorospe M. LncRNA OIP5-AS1-directed miR-7 degradation promotes MYMX production during human myogenesis. Nucleic Acids Res. 2022 Jul 8;50(12):7115-7133. doi: 10.1093/nar/gkac524.

Xi Chen

Naselsky W, Adhikary G, Shrestha S, Chen X, Ezeka G, Xu W, Friedberg JS, Eckert RL. Transglutaminase 2 enhances hepatocyte growth factor signaling to drive the mesothelioma cancer cell phenotype. Mol Carcinog. 2022 Jun;61(6):537-548. doi: 10.1002/mc.23399.

Chen X, Adhikary G, Ma E, Newland JJ, Naselsky W, Xu W, Eckert RL. Sulforaphane inhibits CD44v6/YAP1/TEAD signaling to suppress the cancer phenotype. Mol Carcinog. 2022 Oct 26. doi: 10.1002/mc.23479.

Adhikary G, Shrestha S, Naselsky W, Newland JJ, Chen X, Xu W, Emadi A, Friedberg JS, Eckert RL. Mesothelioma cancer cells are glutamine addicted and glutamine restriction reduces YAP1 signaling to attenuate tumor formation. Mol Carcinog. 2022 Dec 23. doi: 10.1002/mc.23497.

Laban M, Chen X, Guo B. Seromucinous and Mucinous Borderline Ovarian Tumors: We Need to Know More. Reprod Sci. 2022 Dec 6. doi: 10.1007/s43032-022-01143-2.

Eric Choi

Fox ME, Wulff AB, Franco D, Choi EY, Calarco CA, Engeln M, Turner MD, Chandra R, Rhodes VM, Thompson SM, Ament SA, Lobo MK. Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence. Biol Psychiatry. 2022 Aug 30:S0006-3223(22)01551-7. doi: 10.1016/j.biopsych.2022.08.023.

Engeln M, Fox ME, Chandra R, Choi EY, Nam H, Qadir H, Thomas SS, Rhodes VM, Turner MD, Herman RJ, Calarco CA, Lobo MK. Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward. Mol Psychiatry. 2022 Oct;27(10):3980-3991. doi: 10.1038/s41380-022-01668-7.

Amara Ejikemeuwa

Zhang J, Ejikemeuwa A, Gerzanich V, Nasr M, Tang Q, Simard JM, Zhao RY. Understanding the Role of SARS-CoV-2 ORF3a in Viral Pathogenesis and COVID-19. Front Microbiol. 2022 Mar 9;13:854567. doi: 10.3389/fmicb.2022.854567.

Geraldine Ezeka

Naselsky W, Adhikary G, Shrestha S, Chen X, Ezeka G, Xu W, Friedberg JS, Eckert RL. Transglutaminase 2 enhances hepatocyte growth factor signaling to drive the mesothelioma cancer cell phenotype. Mol Carcinog. 2022 Jun;61(6):537-548. doi: 10.1002/mc.23399.

Daniel Garman

Muriel J, Lukyanenko V, Kwiatkowski T, Bhattacharya S, Garman D, Weisleder N, Bloch RJ. The C2 domains of dysferlin: roles in membrane localization, Ca²⁺ signalling and sarcolemmal repair. J Physiol. 2022 Apr;600(8):1953-1968. doi: 10.1113/JP282648.

Lukyanenko V, Muriel J, Garman D, Breydo L, Bloch RJ. Elevated Ca²⁺ at the triad junction underlies dysregulation of Ca²⁺ signaling in dysferlin-null skeletal muscle. Front Physiol. 2022 Nov 3;13:1032447. doi: 10.3389/fphys.2022.1032447.

Rex Gonzales

Gupta A, Hwang BJ, Benyamien-Roufaeil D, Jain S, Liu S, Gonzales R, Brown RA, Zalzman M, Lu AL. Mammalian MutY Homolog (MYH or MUTYH) is Critical for Telomere Integrity under Oxidative Stress. OBM Geriat. 2022;6(2):196. doi: 10.21926/obm.geriatr.2202196.

Hwang BJ, Gonzales R, Corzine S, Stenson E, Pidugu L, Lu AL. DNA binding by the Rad9A subunit of the Rad9-Rad1-Hus1 complex. PLoS One. 2022 Aug 8;17(8):e0272645. doi: 10.1371/journal.pone.0272645.

Jennifer Mariano

Ranu N, Laitila J, Dugdale HF, Mariano J, Kolb JS, Wallgren-Pettersson C, Witting N, Vissing J, Vilchez JJ, Fiorillo C, Zanoteli E, Auranen M, Jokela M, Tasca G, Claeys KG, Voermans NC, Palmio J, Huovinen S, Moggio M, Beck TN, Kontrogianni-Konstantopoulos A, Granzier H, Ochala J. NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy. Acta Neuropathol Commun. 2022 Dec 17;10(1):185. doi: 10.1186/s40478-022-01491-9.

Mitasha Palha

Palha MS, Legenzov EA, Lamb DR, Zimring JC, Buehler PW, Kao JPY. Superoxide measurement as a novel probe of red blood cell storage quality. Blood Transfus. 2022 Dec 15. doi: 10.2450/2022.0246-22.

Spiridon Sevdalis

Young BD, Cook ME, Costabile BK, Samanta R, Zhuang X, Sevdalis SE, Varney KM, Mancia F, Matysiak S, Lattman E, Weber DJ. Binding and Functional Folding (BFF): A Physiological Framework for Studying Biomolecular Interactions and Allostery. J Mol Biol. 2022 Dec 15;434(23):167872. doi: 10.1016/j.jmb.2022.167872.

Matthew Sherman

Sherman ME, Smith RD, Gardner FM, Goodlett DR, Ernst RK. A Sensitive GC-MS Method for Quantitation of Lipid A Backbone Components and Terminal Phosphate Modifications. J Am Soc Mass Spectrom. 2022 Dec 7;33(12):2301-2309. doi: 10.1021/jasms.2c00266.

Montoya NR, Porsch EA, Muñoz VL, Muszyński A, Vlach J, Hahn DK, Azadi P, Sherman M, Yang H, Chandler CE, Ernst RK, St Geme JW 3rd. Surface Anchoring of the Kingella kingae Galactan Is Dependent on the Lipopolysaccharide O-Antigen. mBio. 2022 Oct 26;13(5):e0229522. doi: 10.1128/mbio.02295-22.

Megan Stemberger

Mathias TJ, Ju JA, Lee RM, Thompson KN, Mull ML, Annis DA, Chang KT, Ory EC, Stemberger MB, Hotta T, Ohi R, Vitolo MI, Moutin MJ, Martin SS. Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling. Cancers (Basel). 2022 Mar 28;14(7):1707. doi: 10.3390/cancers14071707.

Maria Traficante

Bamgboye MA, Herold KG, Vieira DCO, Traficante MK, Rogers PJ, Ben-Johny M, Dick IE. CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms. J Gen Physiol. 2022 Nov 7;154(11):e202213209. doi: 10.1085/jgp.202213209.

Bamgboye MA, Traficante MK, Owoyemi J, DiSilvestre D, Vieira DCO, Dick IE. Impaired Ca_V1.2 inactivation reduces the efficacy of calcium channel blockers in the treatment of LQT8. J Mol Cell Cardiol. 2022 Dec;173:92-100. doi: 10.1016/j.yjmcc.2022.10.003.

Brianna Young

Young BD, Cook ME, Costabile BK, Samanta R, Zhuang X, Sevdalis SE, Varney KM, Mancia F, Matysiak S, Lattman E, Weber DJ. Binding and Functional Folding (BFF): A Physiological Framework for Studying Biomolecular Interactions and Allostery. J Mol Biol. 2022 Dec 15;434(23):167872. doi: 10.1016/j.jmb.2022.167872.

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Epidemiology & Human Genetics

Matthew Adams

Sobota RS, Goron AR, Berry AA, Bailey JA, Coulibaly D, Adams M, Kone AK, Kouriba B, Doumbo OK, Sztein MB, Felgner PL, Plowe CV, Lyke KE, Thera MA, Travassos MA. Serologic and Cytokine Profiles of Children with Concurrent Cerebral Malaria and Severe Malarial Anemia Are Distinct from Other Subtypes of Severe Malaria. Am J Trop Med Hyg. 2022 Jun 13;107(2):315–9. doi: 10.4269/ajtmh.22-0135.

Ouattara A, Dwivedi A, Adams M, Niangaly A, Laurens MB, Nyunt MM, Plowe CV, Djimde A, Takala-Harrison S, Silva JC. An In Silico Analysis of Malaria Pre-Erythrocytic-Stage Antigens Interpreting Worldwide Genetic Data to Suggest Vaccine Candidate Variants and Epitopes. Microorganisms. 2022 May 25;10(6):1090. doi: 10.3390/microorganisms10061090.

Mungwira RG, Laurens MB, Nyangulu W, Divala TH, Nampota-Nkomba N, Buchwald AG, Nyirenda OM, Mwinjiwa E, Kanjala M, Galileya LT, Earland DE, Adams M, Plowe CV, Taylor TE, Mallewa J, van Oosterhout JJ, Laufer MK; TSCQ Study Team. High burden of malaria among Malawian adults on antiretroviral therapy after discontinuing prophylaxis. AIDS. 2022 Oct 1;36(12):1675-1682. doi: 10.1097/QAD.0000000000003317.

David Annis

Mathias TJ, Ju JA, Lee RM, Thompson KN, Mull ML, Annis DA, Chang KT, Ory EC, Stemberger MB, Hotta T, Ohi R, Vitolo MI, Moutin MJ, Martin SS. Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling. Cancers (Basel). 2022 Mar 28;14(7):1707. doi: 10.3390/cancers14071707.

Miriam Doyinsola Bailey

Bailey MD, Wickwire EM, Somers VK, Albrecht JS. Adherence to continuous positive airway pressure reduces the risk of 30-day hospital readmission among older adults with comorbid obstructive sleep apnea and cardiovascular disease. J Clin Sleep Med. 2022 Dec 1;18(12):2739-2744. doi: 10.5664/jcsm.10196.

Wickwire EM, Bailey MD, Somers VK, Oldstone LM, Srivastava MC, Johnson AM, Scharf SM, Albrecht JS. CPAP adherence is associated with reduced inpatient utilization among older adult Medicare beneficiaries with pre-existing cardiovascular disease. J Clin Sleep Med. 2022 Jan 1;18(1):39-45. doi: 10.5664/jcsm.9478.

Sarah Brown

France M, Alizadeh M, Brown S, Ma B, Ravel J. Towards a deeper understanding of the vaginal microbiota. Nat Microbiol. 2022 Mar;7(3):367-378. doi: 10.1038/s41564-022-01083-2.

France MT, Brown SE, Rompalo AM, Brotman RM, Ravel J. Identification of shared bacterial strains in the vaginal microbiota of related and unrelated reproductive-age mothers and daughters using genome-resolved metagenomics. PLoS One. 2022 Oct 26;17(10):e0275908. doi: 10.1371/journal.pone.0275908.

Brown SE, He X, Shardell MD, Ravel J, Ghanem KG, Zenilman JM, Brotman RM. Douching cessation and molecular bacterial vaginosis: a reanalysis of archived specimens. Sex Transm Infect. 2022 May 30:sextrans-2022-055459. doi: 10.1136/sextrans-2022-055459.

Ilynn Bulatao

Croteau D, Pinnow E, Wu E, Muñoz M, Bulatao I, Dal Pan G. Sources of Evidence Triggering and Supporting Safety-Related Labeling Changes: A 10-Year Longitudinal Assessment of 22 New Molecular Entities Approved in 2008 by the US Food and Drug Administration. Drug Saf. 2022 Feb;45(2):169-180. doi: 10.1007/s40264-021-01142-3.

Akinboro O, Larkins E, Pai-Scherf LH, Mathieu LN, Ren Y, Cheng J, Fiero MH, Fu W, Bi Y, Kalavar S, Jafri S, Mishra-Kalyani PS, Fourie Zirkelbach J, Li H, Zhao H, He K, Helms WS, Chuk MK, Wang M, Bulatao I, Herz J, Osborn BL, Xu Y, Liu J, Gong Y, Sickafuse S, Cohen R, Donoghue M, Pazdur R, Beaver JA, Singh H. FDA Approval Summary: Pembrolizumab, Atezolizumab, and Cemiplimab-rwlc as Single Agents for First-Line Treatment of Advanced/Metastatic PD-L1-High NSCLC. Clin Cancer Res. 2022 Jun 1;28(11):2221-2228. doi: 10.1158/1078-0432.CCR-21-3844.

Kimberly Claeys

Mody L, Akinboyo IC, Babcock HM, Bischoff WE, Cheng VC, Chiotos K, Claeys KC, Coffey KC, Diekema DJ, Donskey CJ, Ellingson KD, Gilmartin HM, Gohil SK, Harris AD, Keller SC, Klein EY, Krein SL, Kwon JH, Lauring AS, Livorsi DJ, Lofgren ET, Merrill K, Milstone AM, Monsees EA, Morgan DJ, Perri LP, Pfeiffer CD, Rock C, Saint S, Sickbert-Bennett E, Skelton F, Suda KJ, Talbot TR, Vaughn VM, Weber DJ, Wiemken TL, Yassin MH, Ziegler MJ, Anderson DJ; SHEA Research Committee. Coronavirus disease 2019 (COVID-19) research agenda for healthcare epidemiology. Infect Control Hosp Epidemiol. 2022 Feb;43(2):156-166. doi: 10.1017/ice.2021.25.

Chang J, Patel D, Vega A, Claeys KC, Heil EL, Scheetz MH. Does calculation method matter for targeting vancomycin area under the curve? J Antimicrob Chemother. 2022 Jul 28;77(8):2245-2250. doi: 10.1093/jac/dkac151.

Sullivan KV, Gallagher JC, Leekha S, Morgan DJ, Morita K, Rock C, Claeys KC. Use of diagnostic and antimicrobial stewardship practices to improve Clostridioides difficile testing among SHEA Research Network hospitals. Infect Control Hosp Epidemiol. 2022 Jul;43(7):930-934. doi: 10.1017/ice.2021.133.

Kenaa B, O'Hara NN, O'Hara LM, Claeys KC, Leekha S. Understanding healthcare provider preferences for ordering respiratory cultures to diagnose ventilator associated pneumonia: A discrete choice experiment. Antimicrob Steward Healthc Epidemiol. 2022 Jul 15;2(1):e120. doi: 10.1017/ash.2022.267.

Rock C, Perlmutter R, Blythe D, Bork J, Claeys K, Cosgrove SE, Dzintars K, Fabre V, Harris AD, Heil E, Hsu YJ, Keller S, Maragakis LL, Milstone AM, Morgan DJ, Dullabh P, Ubri PS, Rotondo C, Brooks R, Leekha S. Impact of Statewide Prevention and Reduction of Clostridioides difficile (SPARC), a Maryland public health-academic collaborative: an evaluation of a quality improvement intervention. BMJ Qual Saf. 2022 Feb;31(2):153-162. doi: 10.1136/bmjqs-2021-014014.

Noval MM, Leekha S, Armahizer M, Celotto A, Bhatt M, Seung H, Claeys K. Evaluating the incidence of bacteriuria in female patients before and after implementation of external urinary collection devices. Antimicrob Steward Healthc Epidemiol. 2022 Mar 17;2(1):e44. doi: 10.1017/ash.2022.30. 

Goodman KE, Heil EL, Claeys KC, Banoub M, Bork JT. Real-world Antimicrobial Stewardship Experience in a Large Academic Medical Center: Using Statistical and Machine Learning Approaches to Identify Intervention "Hotspots" in an Antibiotic Audit and Feedback Program. Open Forum Infect Dis. 2022 Jun 10;9(7):ofac289. doi: 10.1093/ofid/ofac289.

Advani SD, Claeys K. Cefepime/Enmetazobactam for Complicated Urinary Tract Infections. JAMA. 2022 Oct 4;328(13):1299-1301. doi: 10.1001/jama.2022.15228.

Buzzalino LG, Mease J, Bernhardi CL, Bork JT, Johnson JK, Claeys KC. Follow-up Blood Culture Practices for Gram-Negative Bloodstream Infections in Immunocompromised Hosts at a Large Academic Medical Center. Open Forum Infect Dis. 2022 Apr 15;9(5):ofac173. doi: 10.1093/ofid/ofac173.

O'Hara NN, Carullo J, Joshi M, Banoub M, Claeys KC, Sprague S, Slobogean GP, O'Toole RV; PREP-IT Investigators. Does cumulative topical antibiotic powder use increase the risk of drug induced acute kidney injury in fracture patients? Bone Jt Open. 2022 Apr;3(4):284-290. doi: 10.1302/2633-1462.34.BJO-2022-0009.R1.

Zasowski EJ, Trinh TD, Claeys KC, Lagnf AM, Bhatia S, Klinker KP, Veve MP, Estrada SJ, Johns ST, Sawyer AJ, Huang V, LaFrance B, Levine DP, Kaye KS, Davis SL, Rybak MJ. Multicenter Cohort Study of Ceftaroline Versus Daptomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection. Open Forum Infect Dis. 2021 Dec 23;9(3):ofab606. doi: 10.1093/ofid/ofab606.

Claeys KC, Trautner BW, Leekha S, Coffey KC, Crnich CJ, Diekema DJ, Fakih MG, Goetz MB, Gupta K, Jones MM, Leykum L, Liang SY, Pineles L, Pleiss A, Spivak ES, Suda KJ, Taylor JM, Rhee C, Morgan DJ. Optimal Urine Culture Diagnostic Stewardship Practice-Results from an Expert Modified-Delphi Procedure. Clin Infect Dis. 2022 Aug 31;75(3):382-389. doi: 10.1093/cid/ciab987.

Bing Guo

Baumdicker F, Bisschop G, Goldstein D, Gower G, Ragsdale AP, Tsambos G, Zhu S, Eldon B, Ellerman EC, Galloway JG, Gladstein AL, Gorjanc G, Guo B, Jeffery B, Kretzschumar WW, Lohse K, Matschiner M, Nelson D, Pope NS, Quinto-Cortés CD, Rodrigues MF, Saunack K, Sellinger T, Thornton K, van Kemenade H, Wohns AW, Wong Y, Gravel S, Kern AD, Koskela J, Ralph PL, Kelleher J. Efficient ancestry and mutation simulation with msprime 1.0. Genetics. 2022 Mar 3;220(3):iyab229. doi: 10.1093/genetics/iyab229.

Laban M, Chen X, Guo B. Seromucinous and Mucinous Borderline Ovarian Tumors: We Need to Know More. Reprod Sci. 2022 Dec 6. doi: 10.1007/s43032-022-01143-2.

Kathleen Gwilliam

Taiber S, Gwilliam K, Hertzano R, Avraham KB. The Genomics of Auditory Function and Disease. Annu Rev Genomics Hum Genet. 2022 Aug 31;23:275-299. doi: 10.1146/annurev-genom-121321-094136.

Shisi He

He S, Berndt SI, Kunzmann AT, Kitahara CM, Huang WY, Barry KH. Weight Change and Incident Distal Colorectal Adenoma Risk in the PLCO Cancer Screening Trial. JNCI Cancer Spectr. 2022 Feb 1;6(1):pkab098. doi: 10.1093/jncics/pkab098.

Elizabeth Humphries

Hasin N, Riggs LM, Shekhtman T, Ashworth J, Lease R, Oshone RT, Humphries EM, Badner JA, Thomson PA, Glahn DC, Craig DW, Edenberg HJ, Gershon ES, McMahon FJ, Nurnberger JI, Zandi PP, Kelsoe JR, Roach JC, Gould TD, Ament SA. Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder. Mol Psychiatry. 2022 Sep;27(9):3842-3856. doi: 10.1038/s41380-022-01609-4.

Gulam Kibria

Kibria GMA, Das Gupta R, Crispen R. Association of leisure-time physical activity with perceived general health status among hypertensive people: an analysis of NHANES 2015-18. J Hum Hypertens. 2022 Mar;36(3):280-288. doi: https://doi.org/10.1038/s41371-021-00518-3.

Jindal G, Almardawi R, Gupta R, Colby GP, Schirmer CM, Satti SR, Pukenas B, Hui FK, Caplan J, Miller T, Cherian J, Aldrich F, Kibria G, Simard JM; ULTRA Study Investigators. Target Ultra and Nano coils in the endovascular treatment of small intracranial aneurysms (ULTRA Registry). J Neurosurg. 2022 Jun 24;138(1):233-240. doi: 10.3171/2022.5.JNS2296.

Douglas Loesch

Loesch DP, Horimoto ARVR, Sarihan EI, Inca-Martinez M, Mason E, Cornejo-Olivas M, Torres L, Mazzetti P, Cosentino C, Sarapura-Castro E, Rivera-Valdivia A, Medina AC, Dieguez E, Raggio V, Lescano A, Tumas V, Borges V, Ferraz HB, Rieder CR, Schumacher-Schuh A, Santos-Lobato BL, Velez-Pardo C, Jimenez-Del-Rio M, Lopera F, Moreno S, Chana-Cuevas P, Fernandez W, Arboleda G, Arboleda H, Arboleda-Bustos CE, Yearout D, Zabetian CP; International Parkinson Disease Genomics Consortium (IPDGC); Thornton TA, Mata IF, O'Connor TD; Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD). Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort. Parkinsonism Relat Disord. 2022 Sep;102:7-15. doi: 10.1016/j.parkreldis.2022.06.010.

DiCorpo D, Gaynor SM, Russell EM, Westerman KE, Raffield LM, Majarian TD, Wu P, Sarnowski C, Highland HM, Jackson A, Hasbani NR, de Vries PS, Brody JA, Hidalgo B, Guo X, Perry JA, O'Connell JR, Lent S, Montasser ME, Cade BE, Jain D, Wang H, D'Oliveira Albanus R, Varshney A, Yanek LR, Lange L, Palmer ND, Almeida M, Peralta JM, Aslibekyan S, Baldridge AS, Bertoni AG, Bielak LF, Chen CS, Chen YI, Choi WJ, Goodarzi MO, Floyd JS, Irvin MR, Kalyani RR, Kelly TN, Lee S, Liu CT, Loesch D, Manson JE, Minster RL, Naseri T, Pankow JS, Rasmussen-Torvik LJ, Reiner AP, Reupena MS, Selvin E, Smith JA, Weeks DE, Xu H, Yao J, Zhao W, Parker S, Alonso A, Arnett DK, Blangero J, Boerwinkle E, Correa A, Cupples LA, Curran JE, Duggirala R, He J, Heckbert SR, Kardia SLR, Kim RW, Kooperberg C, Liu S, Mathias RA, McGarvey ST, Mitchell BD, Morrison AC, Peyser PA, Psaty BM, Redline S, Shuldiner AR, Taylor KD, Vasan RS, Viaud-Martinez KA, Florez JC, Wilson JG, Sladek R, Rich SS, Rotter JI, Lin X, Dupuis J, Meigs JB, Wessel J, Manning AK. Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program. Commun Biol. 2022 Jul 28;5(1):756. doi: 10.1038/s42003-022-03702-4.

Megan Lynch

Xu H, Nguyen K, Gaynor BJ, Ling H, Zhao W, McArdle PF, O'Connor TD, Stine OC, Ryan KA, Lynch M, Smith JA, Faul JD, Hu Y, Haessler JW, Fornage M, Kooperberg C, On Behalf Of The Trans-Omics For Precision Medicine TOPMed Stroke Working Group, Perry JA, Hong CC, Cole JW, Pugh E, Doheny K, Kardia SLR, Weir DR, Kittner SJ, Mitchell BD; SiGN Consortium. Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium. Genes (Basel). 2022 Dec 24;14(1):61. doi: 10.3390/genes14010061.

Lynch MT, Maloney KA, Pollin TI, Streeten EA, Puffenberger EG, Strauss KA; Regeneron Genetics Center; Shuldiner AR, Mitchell BD. Impact of parental relatedness on reproductive outcomes among the Old Order Amish of Lancaster County. Am J Med Genet A. 2022 Jul;188(7):2119-2128. doi: 10.1002/ajmg.a.62757.

Kareshma Mohanty

Schmalzle SA, Viviano NA, Mohanty K, Palmeiro RM, Hoffmann JD, Sheth-Pandit N, Gruber-Baldini A, Stafford KA. People aging with HIV - protecting a population vulnerable to effects of COVID-19 and its control measures. AIDS Care. 2021 Dec 24:1-9. doi: 10.1080/09540121.2021.2020208.

Saleha Munir

Munir WM, Munir SZ. Characteristics of Semiautomated Endothelial Cell-Density Measurements Among Corneal Donor Eyes. JAMA Ophthalmol. 2022 Sep 1;140(9):885-888. doi: 10.1001/jamaophthalmol.2022.2782.

Kelsey Murt

Bernier M, Enamorado IN, Gómez-Cabrera MC, Calvo-Rubio M, González-Reyes JA, Price NL, Cortés-Rodríguez AB, Rodríguez-Aguilera JC, Rodríguez-López S, Mitchell SJ, Murt KN, Kalafut K, Williams KM, Ward CW, Stains JP, Brea-Calvo G, Villalba JM, Cortassa S, Aon MA, de Cabo R. Age-dependent impact of two exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver of male mice. NPJ Aging. 2022 Jun 27;8(1):8. doi: 10.1038/s41514-022-00089-8.

Ateudjieu J, Sack DA, Nafack SS, Xiao S, Tchio-Nighie KH, Tchokomeni H, Bita'a LB, Nyibio PN, Guenou E, Mondung KM, Dieumo FFK, Ngome RM, Murt KN, Ram M, Ali M, Debes AK. An Age-stratified, Randomized Immunogenicity Trial of Killed Oral Cholera Vaccine with Delayed Second Dose in Cameroon. Am J Trop Med Hyg. 2022 Nov 14;107(5):974-983. doi: 10.4269/ajtmh.22-0462.

Goedeke L, Murt KN, Di Francesco A, Camporez JP, Nasiri AR, Wang Y, Zhang XM, Cline GW, de Cabo R, Shulman GI. Sex- and strain-specific effects of mitochondrial uncoupling on age-related metabolic diseases in high-fat diet-fed mice. Aging Cell. 2022 Feb;21(2):e13539. doi: 10.1111/acel.13539.

Mwaba J, Chisenga CC, Xiao S, Ng'ombe H, Banda E, Shea P, Mabula-Bwalya C, Mwila-Kazimbaya K, Laban NM, Alabi P, Chirwa-Chobe M, Simuyandi M, Harris J, Iyer AS, Bosomprah S, Scalzo P, Murt KN, Ram M, Kwenda G, Ali M, Sack DA, Chilengi R, Debes AK. Serum vibriocidal responses when second doses of oral cholera vaccine are delayed 6 months in Zambia. Vaccine. 2021 Jul 22;39(32):4516-4523. doi: 10.1016/j.vaccine.2021.06.034.

Gita Nadimpalli

Pineles BL, Goodman KE, Pineles L, O'Hara LM, Nadimpalli G, Magder LS, Baghdadi JD, Parchem JG, Harris AD. Pregnancy and the Risk of In-Hospital Coronavirus Disease 2019 (COVID-19) Mortality. Obstet Gynecol. 2022 May 1;139(5):846-854. doi: 10.1097/AOG.0000000000004744.

Ma B, Sundararajan S, Nadimpalli G, France M, McComb E, Rutt L, Lemme-Dumit JM, Janofsky E, Roskes LS, Gajer P, Fu L, Yang H, Humphrys M, Tallon LJ, Sadzewicz L, Pasetti MF, Ravel J, Viscardi RM. Highly Specialized Carbohydrate Metabolism Capability in Bifidobacterium Strains Associated with Intestinal Barrier Maturation in Early Preterm Infants. mBio. 2022 Jun 28;13(3):e0129922. doi: 10.1128/mbio.01299-22.

Nadimpalli G, O'Hara LM, Magder LS, Johnson JK, Haririan A, Pineles L, Goodman KE, Baghdadi JD, Pineles BL, Harris AD. Comorbidities associated with 30-day readmission following index coronavirus disease 2019 (COVID-19) hospitalization: A retrospective cohort study of 331,136 patients in the United States. Infect Control Hosp Epidemiol. 2022 Oct 3:1-9. doi: 10.1017/ice.2022.232.

Schrank GM, Sick-Samuels A, Bleasdale SC, Jacob JT, Dantes R, Gokhale RH, Mayer J, Mehrotra P, Mehta SA, Mena Lora AJ, Ray SM, Rhee C, Salinas JL, Seo SK, Shane AL, Nadimpalli G, Milstone AM, Robinson G, Brown CH, Harris AD, Leekha S; CDC Prevention Epicenters Program. Development and evaluation of a structured guide to assess the preventability of hospital-onset bacteremia and fungemia. Infect Control Hosp Epidemiol. 2022 Oct;43(10):1326-1332. doi: 10.1017/ice.2021.528.

Ryan Scalsky

Tavares W, Morais J, Martins JF, Scalsky RJ, Stabler TC, Medeiros MM, Fortes FJ, Arez AP, Silva JC. Malaria in Angola: recent progress, challenges and future opportunities using parasite demography studies. Malar J. 2022 Dec 28;21(1):396. doi: 10.1186/s12936-022-04424-y.

Scalsky RJ, Chen YJ, Ying Z, Perry JA, Hong CC. The Social and Natural Environment's Impact on SARS-CoV-2 Infections in the UK Biobank. Int J Environ Res Public Health. 2022 Jan 4;19(1):533. doi: 10.3390/ijerph19010533.

Richard Smith

Sherman ME, Smith RD, Gardner FM, Goodlett DR, Ernst RK. A Sensitive GC-MS Method for Quantitation of Lipid A Backbone Components and Terminal Phosphate Modifications. J Am Soc Mass Spectrom. 2022 Dec 7;33(12):2301-2309. doi: 10.1021/jasms.2c00266.

Yang H, Smith RD, Chandler CE, Johnson JK, Jackson SN, Woods AS, Scott AJ, Goodlett DR, Ernst RK. Lipid A Structural Determination from a Single Colony. Anal Chem. 2022 May 31;94(21):7460-7465. doi: 10.1021/acs.analchem.1c05394.

Ha M, Ngaage LM, Smith RD, Izac JR, Kim PC, Singh D, Slezak S, Ernst RK, Harro J, Rasko YM. An In Vitro Model of the Efficacy of Breast Implant Irrigant Solutions Against Gram-Negative Infections. Ann Plast Surg. 2022 Dec 1;89(6):679-683. doi: 10.1097/SAP.0000000000003302.

Smith RD, McElheny CL, Izac JR, Gardner FM, Chandler CE, Goodlett DR, Doi Y, Johnson JK, Ernst RK. A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin-Resistant Enterobacter Species. Microbiol Spectr. 2022 Feb 23;10(1):e0144521. doi: 10.1128/spectrum.01445-21.

Bray AS, Smith RD, Hudson AW, Hernandez GE, Young TM, George HE, Ernst RK, Zafar MA. MgrB-Dependent Colistin Resistance in Klebsiella pneumoniae Is Associated with an Increase in Host-to-Host Transmission. mBio. 2022 Apr 26;13(2):e0359521. doi: 10.1128/mbio.03595-21.

Yang H, Smith RD, Sumner KP, Goodlett DR, Johnson JK, Ernst RK. A Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Direct-from-Urine-Specimen Diagnostic for Gram-Negative Pathogens. Microbiol Spectr. 2022 Dec 21;10(6):e0373022. doi: 10.1128/spectrum.03730-22.

Smith RD, Izac JR, Ha M, Yang H, Johnson JK, Ernst RK. Rapid identification of mcr-1-positive Escherichia coli from patient urine using a novel lipid-based MALDI-TOF-MS assay. Access Microbiol. 2021 Dec 17;3(12):000309. doi: 10.1099/acmi.0.000309.

Smith RD, Johnson JK, Clay C, Girio-Herrera L, Stevens D, Abraham M, Zimand P, Ahlman M, Gimigliano S, Zhao R, Hildenbrand C, Barrueto F, Leekha S. Clinical evaluation of Sofia Rapid Antigen Assay for detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among emergency department to hospital admissions. Infect Control Hosp Epidemiol. 2022 Aug;43(8):968-973. doi: 10.1017/ice.2021.281.

Emily Stucke

Zhou AE, Jain A, Nakajima R, Shrestha B, Stucke EM, Joshi S, Strauss KA, Hedde PN, Berry AA, Felgner PL, Travassos MA. Protein Microarrays as a Tool to Analyze Antibody Responses to Variant Surface Antigens Expressed on the Surface of Plasmodium falciparum-Infected Erythrocytes. Methods Mol Biol. 2022;2470:343-358. doi: 10.1007/978-1-0716-2189-9_25.

William Still

Samson ME, Still WL, Mark-Carew M, Jarris DK, Idris A, van Zyl A, Addo D, Ashley P, Ike OJ, Thomas ES, Mangla AT, Nesbitt LS. Utility of a Test-to-Return Strategy to Identify Individuals With Coronavirus Disease 2019 (COVID-19) in the Prekindergarten Through Grade 12 School Setting-District of Columbia, January 2022. Clin Infect Dis. 2022 Oct 3;75(Suppl 2):S231-S235. doi: 10.1093/cid/ciac440. Erratum in: Clin Infect Dis. 2022 Nov 30;75(11):2051.

Lora Stojanovic

Kogan AA, Topper MJ, Dellomo AJ, Stojanovic L, McLaughlin LJ, Creed TM, Eberly CL, Kingsbury TJ, Baer MR, Kessler MD, Baylin SB, Rassool FV. Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2123227119. doi: 10.1073/pnas.2123227119.

Zhenyao Ye

Mo C, Wang J, Ye Z, Ke H, Liu S, Hatch K, Gao S, Magidson J, Chen C, Mitchell BD, Kochunov P, Hong LE, Ma T, Chen S. Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank. Addiction. 2022 Nov 18. doi: 10.1111/add.16088.

Ke H, Ren Z, Qi J, Chen S, Tseng GC, Ye Z, Ma T. High-dimension to high-dimension screening for detecting genome-wide epigenetic and noncoding RNA regulators of gene expression. Bioinformatics. 2022 Sep 2;38(17):4078-4087. doi: 10.1093/bioinformatics/btac518.

Mo C, Ye Z, Ke H, Lu T, Canida T, Liu S, Wu Q, Zhao Z, Ma Y, Hong LE, Kochunov P, Ma T, Chen S. A new Mendelian Randomization method to estimate causal effects of multivariable brain imaging exposures. Pac Symp Biocomput. 2022;27:73-84.

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Gerontology

Ranyah Almardawi

Davis DL, Almardawi R, Awan OA, Lo LY, Ahmed SR, Jubouri S, Gullapalli RP. Supraspinatus fatty infiltration on MRI among older adults receiving physical therapy as initial management for clinically suspected rotator cuff tear: A pilot study. J Clin Imaging Sci. 2022 Dec 22;12:66. doi: 10.25259/JCIS_138_2022.

Addona J, Ahmed SR, Almardawi R, Garcia Zapata L, Awan OA, Davis DL. Estimating 3D supraspinatus intramuscular fatty infiltration in older adults: a pilot study. Acta Radiol. 2022 Nov 24:2841851221139597. doi: 10.1177/02841851221139597.

Davis DL, Almardawi R, Terrin ML. Identification of Community-Dwelling Older Adults With Shoulder Dysfunction: A Pilot Study to Evaluate the Disabilities of the Arm, Shoulder and Hand Survey. Geriatr Orthop Surg Rehabil. 2022 Oct 10;13:21514593221129177. doi: 10.1177/21514593221129177.

Jindal G, Almardawi R, Gupta R, Colby GP, Schirmer CM, Satti SR, Pukenas B, Hui FK, Caplan J, Miller T, Cherian J, Aldrich F, Kibria G, Simard JM; ULTRA Study Investigators. Target Ultra and Nano coils in the endovascular treatment of small intracranial aneurysms (ULTRA Registry). J Neurosurg. 2022 Jun 24;138(1):233-240. doi: 10.3171/2022.5.JNS2296.

Jiang L, El-Metwally D, Sours Rhodes C, Zhuo J, Almardawi R, Medina AE, Wang L, Gullapalli RP, Raghavan P. Alterations in motor functional connectivity in Neonatal Hypoxic Ischemic Encephalopathy. Brain Inj. 2022 Jan 28;36(2):287-294. doi: 10.1080/02699052.2022.2034041.

Rashmita Bajracharya

Shakya S, Bajracharya R, Ledbetter L, Cary MP Jr. The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review. Innov Aging. 2022 May 25;6(5):igac032. doi: 10.1093/geroni/igac032.

Bajracharya R, Guralnik JM, Shardell MD, Rathbun AM, Yamashita T, Hochberg MC, Gruber-Baldini AL, Magaziner JS, Orwig DL. Long-term sex differences in all-cause and infection-specific mortality post hip fracture. J Am Geriatr Soc. 2022 Jul;70(7):2107-2114. doi: 10.1111/jgs.17800.

Orwig DL, Abraham DS, Hochberg MC, Gruber-Baldini A, Guralnik JM, Cappola AR, Golden J, Hicks GE, Miller RR, Resnick B, Shardell M, Sterling RS, Bajracharya R, Magaziner J. Sex Differences in Recovery Across Multiple Domains Among Older Adults With Hip Fracture. J Gerontol A Biol Sci Med Sci. 2022 Jul 5;77(7):1463-1471. doi: 10.1093/gerona/glab271.

Jocelyn Robinson Brown

Davitt JK, Brown J. Using Voice and Touchscreen Controlled Smart Speakers to Protect Vulnerable Clients in Long-Term Care Facilities. Innov Aging. 2022 Apr 15;6(4):igac024. doi: 10.1093/geroni/igac024.

Brown JL. Addressing Racial Capitalism's Impact on Black Essential Workers During the COVID-19 Pandemic: Policy Recommendations. J Racial Ethn Health Disparities. 2022 Jun 10:1–8. doi: 10.1007/s40615-022-01346-y.

Rachel McPherson

Resnick B, Galik E, McPherson R, Boltz M, Van Haitsma K, Kolanowski A. Gender Differences in Disease, Function, and Behavioral Symptoms in Residents with Dementia. West J Nurs Res. 2022 Sep;44(9):812-821. doi: 10.1177/01939459211018822.

Shalini Sahoo

Mayorga-Carlin M, Shaw P, Ozsvath K, Erben Y, Wang G, Sahoo S, Macdonald S, Kashyap VS, Sorkin JD, Lal BK. Transcarotid revascularization outcomes do not differ by patient age or sex. J Vasc Surg. 2022 Jul;76(1):209-219.e2. doi: 10.1016/j.jvs.2022.01.141.

Hayssen H, Cires-Drouet R, Englum B, Nguyen P, Sahoo S, Mayorga-Carlin M, Siddiqui T, Turner D, Yesha Y, Sorkin JD, Lal BK. Systematic review of venous thromboembolism risk categories derived from Caprini score. J Vasc Surg Venous Lymphat Disord. 2022 Nov;10(6):1401-1409.e7. doi: 10.1016/j.jvsv.2022.05.003.

Lal BK, Mayorga-Carlin M, Kashyap V, Jordan W, Mukherjee D, Cambria R, Moore W, Neville RF, Eckstein HH, Sahoo S, Macdonald S, Sorkin JD. Learning curve and proficiency metrics for transcarotid artery revascularization. J Vasc Surg. 2022 Jan 19:S0741-5214(22)00042-8. doi: 10.1016/j.jvs.2021.12.073.

Prasad NK, Englum BR, Mayorga-Carlin M, Turner DJ, Sahoo S, Sorkin JD, Lal BK. Partial COVID-19 vaccination associated with reduction in postoperative mortality and SARS-CoV-2 infection. Am J Surg. 2022 Oct;224(4):1097-1102. doi: 10.1016/j.amjsurg.2022.03.038.

Prasad NK, Mayorga-Carlin M, Sahoo S, Englum BR, Turner DJ, Siddiqui T, Lake R, Sorkin JD, Lal BK. Mid-term Surgery Outcomes in Patients with COVID-19: Results from a Nationwide Analysis. Ann Surg. 2022 Jun 28:10.1097/SLA.0000000000005515. doi: 10.1097/SLA.0000000000005515.

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Molecular Medicine

Madeline Alizadeh

Kwon HJ, Panagos K, Alizadeh M, Bell M, Bourmaf M, Zisman E, Paul P, Sibel L, Wong U. Patients with inflammatory bowel disease are more hesitant about Coronavirus disease 2019 vaccination. Front Med (Lausanne). 2022 Nov 15;9:1005121. doi: 10.3389/fmed.2022.1005121.

Alizadeh M, Raufman JP. Gastrointestinal neoplasia: carcinogenic interaction between bile acids and Helicobacter pylori in the stomach. J Clin Invest. 2022 May 16;132(10):e160194. doi: 10.1172/JCI160194.

Alizadeh M, Schledwitz A, Cheng K, Raufman JP. Mechanistic Clues Provided by Concurrent Changes in the Expression of Genes Encoding the M₁ Muscarinic Receptor, β-Catenin Signaling Proteins, and Downstream Targets in Adenocarcinomas of the Colon. Front Physiol. 2022 Mar 16;13:857563. doi: 10.3389/fphys.2022.857563.

France M, Alizadeh M, Brown S, Ma B, Ravel J. Towards a deeper understanding of the vaginal microbiota. Nat Microbiol. 2022 Mar;7(3):367-378. doi: 10.1038/s41564-022-01083-2.

Alexa Blanchard

Reinl EL, Blanchard AC, Graham EL, Edwards SW, Dionisos CV, McCarthy MM. The immune cell profile of the developing rat brain. Brain Behav Immun. 2022 Nov;106:198-226. doi: 10.1016/j.bbi.2022.08.012.

Robert Brown

Gupta A, Hwang BJ, Benyamien-Roufaeil D, Jain S, Liu S, Gonzales R, Brown RA, Zalzman M, Lu AL. Mammalian MutY Homolog (MYH or MUTYH) is Critical for Telomere Integrity under Oxidative Stress. OBM Geriat. 2022;6(2):196. doi: 10.21926/obm.geriatr.2202196.

Arad M, Brown RA, Khatri R, Taylor RJ, Zalzman M. Direct differentiation of tonsillar biopsy-derived stem cells to the neuronal lineage. Cell Mol Biol Lett. 2021 Aug 18;26(1):38. doi: 10.1186/s11658-021-00279-4.

Heather Buck

Martinez R 3rd, Huang W, Buck H, Rea S, Defnet AE, Kane MA, Shapiro P. Proteomic Changes in the Monolayer and Spheroid Melanoma Cell Models of Acquired Resistance to BRAF and MEK1/2 Inhibitors. ACS Omega. 2022 Jan 18;7(4):3293-3311. doi: 10.1021/acsomega.1c05361.

Christine Carney

Pandey N, Anastasiadis P, Carney CP, Kanvinde PP, Woodworth GF, Winkles JA, Kim AJ. Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment. Adv Drug Deliv Rev. 2022 Sep;188:114415. doi: 10.1016/j.addr.2022.114415.

Katarina Chang

Thompson KN, Ju JA, Ory EC, Pratt SJP, Lee RM, Mathias TJ, Chang KT, Lee CJ, Goloubeva OG, Bailey PC, Chakrabarti KR, Jewell CM, Vitolo MI, Martin SS. Microtubule disruption reduces metastasis more effectively than primary tumor growth. Breast Cancer Res. 2022 Feb 14;24(1):13. doi: 10.1186/s13058-022-01506-2.

Mathias TJ, Ju JA, Lee RM, Thompson KN, Mull ML, Annis DA, Chang KT, Ory EC, Stemberger MB, Hotta T, Ohi R, Vitolo MI, Moutin MJ, Martin SS. Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling. Cancers (Basel). 2022 Mar 28;14(7):1707. doi: 10.3390/cancers14071707.

Andrew Coleman

Garber L, Joca HC, Coleman AK, Boyman L, Lederer WJ, Greiser M. Camera-based Measurements of Intracellular [Na+] in Murine Atrial Myocytes. J Vis Exp. 2022 May 27;(183). doi: 10.3791/59600.

Taylor Crawford

Johnson AA, Crawford TR, Trudeau MC. The N-linker region of hERG1a upregulates hERG1b potassium channels. J Biol Chem. 2022 Sep;298(9):102233. doi: 10.1016/j.jbc.2022.102233.

Anna Dellomo

Kogan AA, Topper MJ, Dellomo AJ, Stojanovic L, McLaughlin LJ, Creed TM, Eberly CL, Kingsbury TJ, Baer MR, Kessler MD, Baylin SB, Rassool FV. Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2123227119. doi: 10.1073/pnas.2123227119.

Abbotts R, Dellomo AJ, Rassool FV. Pharmacologic Induction of BRCAness in BRCA-Proficient Cancers: Expanding PARP Inhibitor Use. Cancers (Basel). 2022 May 26;14(11):2640. doi: 10.3390/cancers14112640.

Dellomo AJ, Abbotts R, Eberly CL, Karbowski M, Baer MR, Kingsbury TJ, Rassool FV. PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers. Transl Oncol. 2022 Jan;15(1):101283. doi: 10.1016/j.tranon.2021.101283. 

Zachary Fasana

Wolf G, Gerber AN, Fasana ZG, Rosenberg K, Singh NJ. Acute effects of FLT3L treatment on T cells in intact mice. Sci Rep. 2022 Nov 14;12(1):19487. doi: 10.1038/s41598-022-24126-4.

Talia Guardia

Tuntithavornwat S, Shea DJ, Wong BS, Guardia T, Lee SJ, Yankaskas CL, Zheng L, Kontrogianni-Konstantopoulos A, Konstantopoulos K. Giant obscurin regulates migration and metastasis via RhoA-dependent cytoskeletal remodeling in pancreatic cancer. Cancer Lett. 2022 Feb 1;526:155-167. doi: 10.1016/j.canlet.2021.11.016.

Brittany Hazzard

Hazzard B, Sá JM, Ellis AC, Pascini TV, Amin S, Wellems TE, Serre D. Long read single cell RNA sequencing reveals the isoform diversity of Plasmodium vivax transcripts. PLoS Negl Trop Dis. 2022 Dec 16;16(12):e0010991. doi: 10.1371/journal.pntd.0010991.

Kevin Herold

Bamgboye MA, Herold KG, Vieira DCO, Traficante MK, Rogers PJ, Ben-Johny M, Dick IE. CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms. J Gen Physiol. 2022 Nov 7;154(11):e202213209. doi: 10.1085/jgp.202213209.

Nicole Higgins

Lin BC, Higgins NR, Phung TH, Monteiro MJ. UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD. FEBS J. 2022 Oct;289(20):6132-6153. doi: 10.1111/febs.16129.

Pranjali Kanvinde

Pandey N, Anastasiadis P, Carney CP, Kanvinde PP, Woodworth GF, Winkles JA, Kim AJ. Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment. Adv Drug Deliv Rev. 2022 Sep;188:114415. doi: 10.1016/j.addr.2022.114415.

Jeffrey Koenig

Ruff AL, Causey RD, Koenig JA, LaGrasta CV, Gomez AM, Chalmers BT, Lehman JG 3rd. siRNA high throughput screening identifies regulators of chloropicrin and hydrogen fluoride injury in human corneal epithelial cell models. Exp Eye Res. 2022 Sep;222:109169. doi: 10.1016/j.exer.2022.109169.

Robert Lease

Hasin N, Riggs LM, Shekhtman T, Ashworth J, Lease R, Oshone RT, Humphries EM, Badner JA, Thomson PA, Glahn DC, Craig DW, Edenberg HJ, Gershon ES, McMahon FJ, Nurnberger JI, Zandi PP, Kelsoe JR, Roach JC, Gould TD, Ament SA. Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder. Mol Psychiatry. 2022 Sep;27(9):3842-3856. doi: 10.1038/s41380-022-01609-4.

Kanwal Mahmood Hameed

Kapadia B, Shetty AC, Bollino D, Bhandary B, Lapidus RG, Mahmood K, Mahurkar A, Gartenhaus RB, Eckert RL, Emadi A. Translatome changes in acute myeloid leukemia cells post exposure to pegcrisantaspase and venetoclax. Exp Hematol. 2022 Jan 31:S0301-472X(22)00036-4. doi: 10.1016/j.exphem.2022.01.006.

Bollino D, Claiborne JP, Hameed K, Ma X, Tighe KM, Carter-Cooper B, Lapidus RG, Strovel ET, Emadi A. Erwinia asparaginase (crisantaspase) increases plasma levels of serine and glycine. Front Oncol. 2022 Dec 12;12:1035537. doi: 10.3389/fonc.2022.1035537.

Adarsha Malla

Alomari S, Kedda J, Malla AP, Pacis V, Anastasiadis P, Xu S, McFarland E, Sukhon L, Gallo B, Rincon-Torroella J, Ben-Shalom N, Ames HM, Brem H, Woodworth GF, Tyler B. Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection. J Vis Exp. 2022 May 9;(183). doi: 10.3791/64048.

Trevor Mathias

Zhang H, Kleinberger JW, Maloney KA, Guan Y, Mathias TJ, Bisordi K, Streeten EA, Blessing K, Snyder MN, Bromberger LA, Goehringer J, Kimball A, Damcott CM, Taylor CO, Nicholson M, Nwaba D, Palmer K, Sewell D, Ambulos N, Jeng LJB, Shuldiner AR, Levin P, Carey DJ, Pollin TI. Model for Integration of Monogenic Diabetes Diagnosis Into Routine Care: The Personalized Diabetes Medicine Program. Diabetes Care. 2022 Aug 1;45(8):1799-1806. doi: 10.2337/dc21-1975.

Thompson KN, Ju JA, Ory EC, Pratt SJP, Lee RM, Mathias TJ, Chang KT, Lee CJ, Goloubeva OG, Bailey PC, Chakrabarti KR, Jewell CM, Vitolo MI, Martin SS. Microtubule disruption reduces metastasis more effectively than primary tumor growth. Breast Cancer Res. 2022 Feb 14;24(1):13. doi: 10.1186/s13058-022-01506-2.

Mathias TJ, Ju JA, Lee RM, Thompson KN, Mull ML, Annis DA, Chang KT, Ory EC, Stemberger MB, Hotta T, Ohi R, Vitolo MI, Moutin MJ, Martin SS. Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling. Cancers (Basel). 2022 Mar 28;14(7):1707. doi: 10.3390/cancers14071707.

Nowak RG, Bentzen SM, Schumaker LM, Ambulos NP, Ndembi N, Dauda W, Mitchell A, Mathias TJ, Crowell TA, Baral SD, Blattner WA, Charurat ME, Palefsky JM, Cullen KJ; TRUST/RV368 Study Group. Evaluating the Jaccard Similarity Index as a Persistence Measure of Multiple Anal Human Papillomavirus Among Nigerian Men Who Have Sex With Men. Sex Transm Dis. 2022 Apr 1;49(4):297-303. doi: 10.1097/OLQ.0000000000001587.

John Mattick

Tvedte ES, Gasser M, Zhao X, Tallon LJ, Sadzewicz L, Bromley RE, Chung M, Mattick J, Sparklin BC, Dunning Hotopp JC. Accumulation of endosymbiont genomes in an insect autosome followed by endosymbiont replacement. Curr Biol. 2022 Jun 20;32(12):2786-2795.e5. doi: 10.1016/j.cub.2022.05.024.

Paige McKeon

McKeon PN, Bunce GW, Patton MH, Chen R, Mathur BN. Cortical control of striatal fast-spiking interneuron synchrony. J Physiol. 2022 May;600(9):2189-2202. doi: 10.1113/JP282850.

Makenzy Mull

Mathias TJ, Ju JA, Lee RM, Thompson KN, Mull ML, Annis DA, Chang KT, Ory EC, Stemberger MB, Hotta T, Ohi R, Vitolo MI, Moutin MJ, Martin SS. Tubulin Carboxypeptidase Activity Promotes Focal Gelatin Degradation in Breast Tumor Cells and Induces Apoptosis in Breast Epithelial Cells That Is Overcome by Oncogenic Signaling. Cancers (Basel). 2022 Mar 28;14(7):1707. doi: 10.3390/cancers14071707.

Kevin Nguyen

Xu H, Nguyen K, Gaynor BJ, Ling H, Zhao W, McArdle PF, O'Connor TD, Stine OC, Ryan KA, Lynch M, Smith JA, Faul JD, Hu Y, Haessler JW, Fornage M, Kooperberg C, On Behalf Of The Trans-Omics For Precision Medicine TOPMed Stroke Working Group, Perry JA, Hong CC, Cole JW, Pugh E, Doheny K, Kardia SLR, Weir DR, Kittner SJ, Mitchell BD; SiGN Consortium. Exome Array Analysis of 9721 Ischemic Stroke Cases from the SiGN Consortium. Genes (Basel). 2022 Dec 24;14(1):61. doi: 10.3390/genes14010061.

Nisha Pawar

Duru N, Pawar NR, Martin EW, Buzza MS, Conway GD, Lapidus RG, Liu S, Reader J, Rao GG, Roque DM, Leppla SH, Antalis TM. Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteases. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2201423119. doi: 10.1073/pnas.2201423119.

Blair Ptak

Cook AL, Wyhs N, Sur S, Ptak B, Popoli M, Dobbyn L, Papadopoulos T, Bettegowda C, Papadopoulos N, Vogelstein B, Zhou S, Kinzler KW. An isogenic cell line panel for sequence-based screening of targeted anticancer drugs. iScience. 2022 May 23;25(6):104437. doi: 10.1016/j.isci.2022.104437.

Philippa Rogers

Bamgboye MA, Herold KG, Vieira DCO, Traficante MK, Rogers PJ, Ben-Johny M, Dick IE. CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms. J Gen Physiol. 2022 Nov 7;154(11):e202213209. doi: 10.1085/jgp.202213209.

Andrea Romanowski

Altas B, Romanowski AJ, Bunce GW, Poulopoulos A. Neuronal mTOR Outposts: Implications for Translation, Signaling, and Plasticity. Front Cell Neurosci. 2022 Apr 7;16:853634. doi: 10.3389/fncel.2022.853634.

Iffland PH, Everett ME, Cobb-Pitstick KM, Bowser LE, Barnes AE, Babus JK, Romanowski AJ, Baybis M, Elziny S, Puffenberger EG, Gonzaga-Jauregui C, Poulopoulos A, Carson VJ, Crino PB. NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold. Brain. 2022 Nov 21;145(11):3872-3885. doi: 10.1093/brain/awac044.

Riccardo Serra

Aarabi B, Chixiang C, Simard JM, Chryssikos T, Stokum JA, Sansur CA, Crandall KM, Olexa J, Oliver J, Meister MR, Cannarsa G, Sharma A, Lomangino C, Scarboro M, Ahmed AK, Han N, Serra R, Shea P, Aresco C, Schwartzbauer GT. Proposal of a Management Algorithm to Predict the Need for Expansion Duraplasty in American Spinal Injury Association Impairment Scale Grades A-C Traumatic Cervical Spinal Cord Injury Patients. J Neurotrauma. 2022 Dec;39(23-24):1716-1726. doi: 10.1089/neu.2022.0218.

Jacob Shaw

Shaw J, Pearson RM. Nanoparticle personalized biomolecular corona: implications of pre-existing conditions for immunomodulation and cancer. Biomater Sci. 2022 May 17;10(10):2540-2549. doi: 10.1039/d2bm00315e.

Truong N, Goodis CC, Cottingham AL, Shaw JR, Fletcher S, Pearson RM. Modified Suberoylanilide Hydroxamic Acid Reduced Drug-Associated Immune Cell Death and Organ Damage under Lipopolysaccharide Inflammatory Challenge. ACS Pharmacol Transl Sci. 2022 Oct 10;5(11):1128-1141. doi: 10.1021/acsptsci.2c00119.

Timothy Troppoli

Troppoli TA, Zanos P, Georgiou P, Gould TD, Rudolph U, Thompson SM. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biol Psychiatry. 2022 Aug 1;92(3):216-226. doi: 10.1016/j.biopsych.2021.11.024.

Nicolas Verhoeven

Karbowski M, Oshima Y, Verhoeven N. Mitochondrial proteotoxicity: implications and ubiquitin-dependent quality control mechanisms. Cell Mol Life Sci. 2022 Oct 29;79(11):574. doi: 10.1007/s00018-022-04604-8.

Ava Zapf

Zapf AM, Grimm PR, Al-Qusairi L, Delpire E, Welling PA. Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice. Front Physiol. 2022 Jan 6;12:787323. doi: 10.3389/fphys.2021.787323.

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Molecular Microbiology & Immunology

Jessica Allen

Brammer J, Wolf G, Baliban SM, Allen JC, Choi M, Kambouris AR, Simon R, Fiskum G, Chao W, Lopez K, Miller C, Singh NJ, Cross AS. A Nonlethal Full-Thickness Flame Burn Produces a Seroma Beneath the Forming Eschar, Thereby Promoting Pseudomonas aeruginosa Sepsis in Mice. J Burn Care Res. 2022 Jul 1;43(4):792-801. doi: 10.1093/jbcr/irab195.

Kenneth Dietze

Mitchell JL, Pollara J, Dietze K, Edwards RW, Nohara J, N'guessan KF, Zemil M, Buranapraditkun S, Takata H, Li Y, Muir R, Kroon E, Pinyakorn S, Jha S, Manasnayakorn S, Chottanapund S, Thantiworasit P, Prueksakaew P, Ratnaratorn N, Nuntapinit B, Fox L, Tovanabutra S, Paquin-Proulx D, Wieczorek L, Polonis VR, Maldarelli F, Haddad EK, Phanuphak P, Sacdalan CP, Rolland M, Phanuphak N, Ananworanich J, Vasan S, Ferrari G, Trautmann L; RV254 and RV304 Study Groups. Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection. J Clin Invest. 2022 Jan 4;132(1):e150937. doi: 10.1172/JCI150937.

Corbin Goerlich

Goerlich CE, Singh A, Treffalls JA, Griffith B, Ayares D, Mohiuddin MM. An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation: Commentary (in response to): Zaman, R. et al. Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress. Immunity 54, 2057-2071.e6 (2021).: Commentary (in response to): Zaman, R. et al. Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress. Immunity 54, 2057-2071.e6 (2021). Xenotransplantation. 2022 Jan;29(1):e12724. doi: 10.1111/xen.12724.

Singh AK, Goerlich CE, Zhang T, Lewis BGT, Hershfeld A, Mohiuddin MM. CD40-CD40L Blockade: Update on Novel Investigational Therapeutics for Transplantation. Transplantation. 2022 Dec 23. doi: 10.1097/TP.0000000000004469.

Singh AK, Griffith BP, Goerlich CE, Ayares D, Mohiuddin MM. The road to the first FDA-approved genetically engineered pig heart transplantation into human. Xenotransplantation. 2022 Sep;29(5):e12776. doi: 10.1111/xen.12776.

Shah A, Goerlich CE, Pasrija C, Hirsch J, Fisher S, Odonkor P, Strauss E, Ayares D, Mohiuddin MM, Griffith BP. Anatomical Differences Between Human and Pig Hearts and Their Relevance for Cardiac Xenotransplantation Surgical Technique. JACC Case Rep. 2022 Jul 7;4(16):1049-1052. doi: 10.1016/j.jaccas.2022.06.011.

Griffith BP, Goerlich CE, Singh AK, Rothblatt M, Lau CL, Shah A, Lorber M, Grazioli A, Saharia KK, Hong SN, Joseph SM, Ayares D, Mohiuddin MM. Genetically Modified Porcine-to-Human Cardiac Xenotransplantation. N Engl J Med. 2022 Jul 7;387(1):35-44. doi: 10.1056/NEJMoa2201422.

Singh AK, Goerlich CE, Shah AM, Zhang T, Tatarov I, Ayares D, Horvath KA, Mohiuddin MM. Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation. Transpl Int. 2022 Mar 23;35:10171. doi: 10.3389/ti.2022.10171.

Mohiuddin MM, Goerlich CE, Singh AK, Zhang T, Tatarov I, Lewis B, Sentz F, Hershfeld A, Braileanu G, Odonkor P, Strauss E, Williams B, Burke A, Hittman J, Bhutta A, Tabatabai A, Gupta A, Vaught T, Sorrells L, Kuravi K, Dandro A, Eyestone W, Kaczorowski DJ, Ayares D, Griffith BP. Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months. Xenotransplantation. 2022 May;29(3):e12744. doi: 10.1111/xen.12744.

Elizabeth Hill

Abdi K, Laky K, Abshari M, Hill EM, Lantz L, Singh NJ, Long EO. Dendritic cells Trigger IFN-γ secretion by NK cells independent of IL-12 and IL-18. Eur J Immunol. 2022 Sep;52(9):1431-1440. doi: 10.1002/eji.202149733.

Casey Hofstaedter

Gerster T, Wröbel M, Hofstaedter CE, Schwudke D, Ernst RK, Ranf S, Gisch N. Remodeling of Lipid A in Pseudomonas syringae pv. phaseolicola In Vitro. Int J Mol Sci. 2022 Feb 11;23(4):1996. doi: 10.3390/ijms23041996.

Wong Fok Lung T, Charytonowicz D, Beaumont KG, Shah SS, Sridhar SH, Gorrie CL, Mu A, Hofstaedter CE, Varisco D, McConville TH, Drikic M, Fowler B, Urso A, Shi W, Fucich D, Annavajhala MK, Khan IN, Oussenko I, Francoeur N, Smith ML, Stockwell BR, Lewis IA, Hachani A, Upadhyay Baskota S, Uhlemann AC, Ahn D, Ernst RK, Howden BP, Sebra R, Prince A. Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection. Cell Metab. 2022 May 3;34(5):761-774.e9. doi: 10.1016/j.cmet.2022.03.009.

Nordstrom HR, Evans DR, Finney AG, Westbrook KJ, Zamora PF, Hofstaedter CE, Yassin MH, Pradhan A, Iovleva A, Ernst RK, Bomberger JM, Shields RK, Doi Y, Van Tyne D. Genomic characterization of lytic bacteriophages targeting genetically diverse Pseudomonas aeruginosa clinical isolates. iScience. 2022 May 10;25(6):104372. doi: 10.1016/j.isci.2022.104372.

Adrienne Kambouris

Brammer J, Wolf G, Baliban SM, Allen JC, Choi M, Kambouris AR, Simon R, Fiskum G, Chao W, Lopez K, Miller C, Singh NJ, Cross AS. A Nonlethal Full-Thickness Flame Burn Produces a Seroma Beneath the Forming Eschar, Thereby Promoting Pseudomonas aeruginosa Sepsis in Mice. J Burn Care Res. 2022 Jul 1;43(4):792-801. doi: 10.1093/jbcr/irab195.

Verhoeve VI, Brammer JA, Driscoll TP, Kambouris AR, Rasko DA, Cross AS, Gillespie JJ. Genome Sequencing of Pseudomonas aeruginosa strain M2 illuminates traits of an opportunistic pathogen of burn wounds. G3 (Bethesda). 2022 Mar 28:jkac073. doi: 10.1093/g3journal/jkac073.

Povilas Kavaliauskas

Kairytė K, Grybaitė B, Vaickelionienė R, Sapijanskaitė-Banevič B, Kavaliauskas P, Mickevičius V. Synthesis and Biological Activity Characterization of Novel 5-Oxopyrrolidine Derivatives with Promising Anticancer and Antimicrobial Activity. Pharmaceuticals (Basel). 2022 Aug 6;15(8):970. doi: 10.3390/ph15080970.

Minickaitė R, Grybaitė B, Vaickelionienė R, Kavaliauskas P, Petraitis V, Petraitienė R, Tumosienė I, Jonuškienė I, Mickevičius V. Synthesis of Novel Aminothiazole Derivatives as Promising Antiviral, Antioxidant and Antibacterial Candidates. Int J Mol Sci. 2022 Jul 12;23(14):7688. doi: 10.3390/ijms23147688.

Kavaliauskas P, Opazo FS, Acevedo W, Petraitiene R, Grybaitė B, Anusevičius K, Mickevičius V, Belyakov S, Petraitis V. Synthesis, Biological Activity, and Molecular Modelling Studies of Naphthoquinone Derivatives as Promising Anticancer Candidates Targeting COX-2. Pharmaceuticals (Basel). 2022 Apr 27;15(5):541. doi: 10.3390/ph15050541. 

James Logue

DeGrace MM, Ghedin E, Frieman MB, Krammer F, Grifoni A, Alisoltani A, Alter G, Amara RR, Baric RS, Barouch DH, Bloom JD, Bloyet LM, Bonenfant G, Boon ACM, Boritz EA, Bratt DL, Bricker TL, Brown L, Buchser WJ, Carreño JM, Cohen-Lavi L, Darling TL, Davis-Gardner ME, Dearlove BL, Di H, Dittmann M, Doria-Rose NA, Douek DC, Drosten C, Edara VV, Ellebedy A, Fabrizio TP, Ferrari G, Fischer WM, Florence WC, Fouchier RAM, Franks J, García-Sastre A, Godzik A, Gonzalez-Reiche AS, Gordon A, Haagmans BL, Halfmann PJ, Ho DD, Holbrook MR, Huang Y, James SL, Jaroszewski L, Jeevan T, Johnson RM, Jones TC, Joshi A, Kawaoka Y, Kercher L, Koopmans MPG, Korber B, Koren E, Koup RA, LeGresley EB, Lemieux JE, Liebeskind MJ, Liu Z, Livingston B, Logue JP, Luo Y, McDermott AB, McElrath MJ, Meliopoulos VA, Menachery VD, Montefiori DC, Mühlemann B, Munster VJ, Munt JE, Nair MS, Netzl A, Niewiadomska AM, O'Dell S, Pekosz A, Perlman S, Pontelli MC, Rockx B, Rolland M, Rothlauf PW, Sacharen S, Scheuermann RH, Schmidt SD, Schotsaert M, Schultz-Cherry S, Seder RA, Sedova M, Sette A, Shabman RS, Shen X, Shi PY, Shukla M, Simon V, Stumpf S, Sullivan NJ, Thackray LB, Theiler J, Thomas PG, Trifkovic S, Türeli S, Turner SA, Vakaki MA, van Bakel H, VanBlargan LA, Vincent LR, Wallace ZS, Wang L, Wang M, Wang P, Wang W, Weaver SC, Webby RJ, Weiss CD, Wentworth DE, Weston SM, Whelan SPJ, Whitener BM, Wilks SH, Xie X, Ying B, Yoon H, Zhou B, Hertz T, Smith DJ, Diamond MS, Post DJ, Suthar MS. Defining the risk of SARS-CoV-2 variants on immune protection. Nature. 2022 May;605(7911):640-652. doi: 10.1038/s41586-022-04690-5.

Shen WB, Elahi M, Logue J, Yang P, Baracco L, Reece EA, Wang B, Li L, Blanchard TG, Han Z, Rissman RA, Frieman MB, Yang P. SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer's-like neuropathology. bioRxiv [Preprint]. 2022 Sep 6:2022.01.31.478476. doi: 10.1101/2022.01.31.478476.

Si L, Bai H, Oh CY, Jiang A, Hong F, Zhang T, Ye Y, Jordan TX, Logue J, McGrath M, Belgur C, Calderon K, Nurani A, Cao W, Carlson KE, Prantil-Baun R, Gygi SP, Yang D, Jonsson CB, tenOever BR, Frieman M, Ingber DE. Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity. Mol Ther Nucleic Acids. 2022 Sep 13;29:923-940. doi: 10.1016/j.omtn.2022.08.031.

Johnson RM, Ardanuy J, Hammond H, Logue J, Jackson L, Baracco L, McGrath M, Dillen C, Patel N, Smith G, Frieman M. Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2. bioRxiv [Preprint]. 2022 Oct 17:2022.10.15.512291. doi: 10.1101/2022.10.15.512291.

Logue J, Chakraborty AR, Johnson R, Goyal G, Rodas M, Taylor LJ, Baracco L, McGrath ME, Haupt R, Furlong BA, Soong M, Prabhala P, Horvath V, Carlson KE, Weston S, Ingber DE, DePamphilis ML, Frieman MB. PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19. Commun Biol. 2022 Aug 12;5(1):808. doi: 10.1038/s42003-022-03766-2.

Liu DX, Cooper TK, Perry DL, Huzella LM, Hischak AMW, Hart RJ, Isic N, Byrum R, Ragland D, St Claire M, Cooper K, Reeder R, Logue J, Jahrling PB, Holbrook MR, Bennett RS, Hensley LE. Expanded Histopathology and Tropism of Ebola Virus in the Rhesus Macaque Model: Potential for Sexual Transmission, Altered Adrenomedullary Hormone Production, and Early Viral Replication in Liver. Am J Pathol. 2022 Jan;192(1):121-129. doi: 10.1016/j.ajpath.2021.09.009.

Sajadi MM, Myers A, Logue J, Saadat S, Shokatpour N, Quinn J, Newman M, Deming M, Rikhtegaran Tehrani Z, Magder LS, Karimi M, Abbasi A, Shlyak M, Baracco L, Frieman MB, Crotty S, Harris AD. Mucosal and Systemic Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination Determined by Severity of Primary Infection. mSphere. 2022 Dec 21;7(6):e0027922. doi: 10.1128/msphere.00279-22.

Sperry MM, Oskotsky T, MariÄ I, Kaushal S, Takeda T, Horvath V, Powers RK, Rodas M, Furlong B, Soong M, Prabhala P, Goyal G, Carlson KE, Wong RJ, Kosti I, Le BL, Logue J, Hammond H, Frieman M, Stevenson DK, Ingber DE, Sirota M, Novak R. Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients. medRxiv [Preprint]. 2022 Jul 22:2022.04.12.22273802. doi: 10.1101/2022.04.12.22273802.

Mallory RM, Formica N, Pfeiffer S, Wilkinson B, Marcheschi A, Albert G, McFall H, Robinson M, Plested JS, Zhu M, Cloney-Clark S, Zhou B, Chau G, Robertson A, Maciejewski S, Hammond HL, Baracco L, Logue J, Frieman MB, Smith G, Patel N, Glenn GM; Novavax 2019nCoV101 Study Group. Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trial. Lancet Infect Dis. 2022 Nov;22(11):1565-1576. doi: 10.1016/S1473-3099(22)00420-0.

Shen WB, Turan S, Wang B, Cojocaru L, Harman C, Logue J, Reece EA, Frieman MB, Yang P. A SARS-CoV-2 Delta Variant Case Manifesting as Extensive Placental Infection and Fetal Transmission. Gynecol Obstet Invest. 2022;87(2):165-172. doi: 10.1159/000524905. 

Hanover Matz

Rajsri KS, McRae MP, Simmons GW, Christodoulides NJ, Matz H, Dooley H, Koide A, Koide S, McDevitt JT. A Rapid and Sensitive Microfluidics-Based Tool for Seroprevalence Immunity Assessment of COVID-19 and Vaccination-Induced Humoral Antibody Response at the Point of Care. Biosensors (Basel). 2022 Aug 10;12(8):621. doi: 10.3390/bios12080621.

Bakke FK, Gundappa MK, Matz H, Stead DA, Macqueen DJ, Dooley H. Exploration of the Nurse Shark (Ginglymostoma cirratum) Plasma Immunoproteome Using High-Resolution LC-MS/MS. Front Immunol. 2022 Jun 6;13:873390. doi: 10.3389/fimmu.2022.873390.

Marisa McGrath

Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 Feb 17;185(4):614-629.e21. doi: 10.1016/j.cell.2022.01.009.

Si L, Bai H, Oh CY, Jiang A, Hong F, Zhang T, Ye Y, Jordan TX, Logue J, McGrath M, Belgur C, Calderon K, Nurani A, Cao W, Carlson KE, Prantil-Baun R, Gygi SP, Yang D, Jonsson CB, tenOever BR, Frieman M, Ingber DE. Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity. Mol Ther Nucleic Acids. 2022 Sep 13;29:923-940. doi: 10.1016/j.omtn.2022.08.031.

Johnson RM, Ardanuy J, Hammond H, Logue J, Jackson L, Baracco L, McGrath M, Dillen C, Patel N, Smith G, Frieman M. Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2. bioRxiv [Preprint]. 2022 Oct 17:2022.10.15.512291. doi: 10.1101/2022.10.15.512291.

Logue J, Chakraborty AR, Johnson R, Goyal G, Rodas M, Taylor LJ, Baracco L, McGrath ME, Haupt R, Furlong BA, Soong M, Prabhala P, Horvath V, Carlson KE, Weston S, Ingber DE, DePamphilis ML, Frieman MB. PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19. Commun Biol. 2022 Aug 12;5(1):808. doi: 10.1038/s42003-022-03766-2.

Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022 Jan 26;14(629):eabj5305. doi: 10.1126/scitranslmed.abj5305.

McGrath ME, Xue Y, Dillen C, Oldfield L, Assad-Garcia N, Zaveri J, Singh N, Baracco L, Taylor LJ, Vashee S, Frieman MB. SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2204717119. doi: 10.1073/pnas.2204717119.

Nanishi E, McGrath ME, O'Meara TR, Barman S, Yu J, Wan H, Dillen CA, Menon M, Seo HS, Song K, Xu AZ, Sebastian L, Brook B, Bosco AN, Borriello F, Ernst RK, Barouch DH, Dhe-Paganon S, Levy O, Frieman MB, Dowling DJ. mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant. Commun Biol. 2022 Aug 6;5(1):790. doi: 10.1038/s42003-022-03765-3.

Sheng Y, Vinjamuri A, Alvarez MRS, Xie Y, McGrath M, Chen S, Barboza M, Frieman M, Lebrilla CB. Host Cell Glycocalyx Remodeling Reveals SARS-CoV-2 Spike Protein Glycomic Binding Sites. Front Mol Biosci. 2022 Mar 14;9:799703. doi: 10.3389/fmolb.2022.799703.

Rodriguez-Rodriguez BA, Ciabattoni GO, Valero-Jimenez AM, Crosse KM, Schinlever AR, Galvan JJR, Duerr R, Yeung ST, McGrath ME, Loomis C, Khanna KM, Desvignes L, Frieman MF, Ortigoza MB, Dittmann M. A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8. bioRxiv [Preprint]. 2022 Oct 24:2022.10.04.510658. doi: 10.1101/2022.10.04.510658.

Meara TR, Nanishi E, McGrath ME, Barman S, Dong D, Dillen C, Menon M, Seo HS, Dhe-Paganon S, Ernst RK, Levy O, Frieman MB, Dowling DJ. Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. bioRxiv [Preprint]. 2022 Dec 7:2022.12.07.519460. doi: 10.1101/2022.12.07.519460.

Brook B, Fatou B, Checkervarty A, Barman S, Sweitzer C, Bosco AN, Sherman A, Baden LR, Morrocchi E, Sanchez-Schmitz G, Palma P, Nanishi E, O'Meara T, McGrath M, Frieman M, Soni D, van Haren S, Ozonoff A, Diray-Arce J, Steen H, Dowling D, Levy O. The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo. Res Sq [Preprint]. 2022 Dec 21:rs.3.rs-2395118. doi: 10.21203/rs.3.rs-2395118/v1.

Anya O'Neal

Narasimhan S, Rajeevan N, Graham M, Wu MJ, DePonte K, Marion S, Masson O, O'Neal AJ, Pedra JHF, Sonenshine DE, Fikrig E. Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiota. Microbiome. 2022 Oct 17;10(1):173. doi: 10.1186/s40168-022-01378-w.

Riley Risteen

Verhoeve VI, Fauntleroy TD, Risteen RG, Driscoll TP, Gillespie JJ. Cryptic Genes for Interbacterial Antagonism Distinguish Rickettsia Species Infecting Blacklegged Ticks From Other Rickettsia Pathogens. Front Cell Infect Microbiol. 2022 May 3;12:880813. doi: 10.3389/fcimb.2022.880813.

Michael Sikorski

Hoffman SA, Desai SN, Sikorski MJ, Fatupaito G, Tupua S, Thomsen RE, Rambocus S, Nimarota-Brown S, Punimata LL, Sialeipata M, Tuilagi CF, Han J, Robins-Browne RM, Naseri TK, Levine MM. Point-of-Care Ultrasound by Nonexpert Operators Demonstrates High Sensitivity and Specificity in Detecting Gallstones: Data from the Samoa Typhoid Fever Control Program. Am J Trop Med Hyg. 2022 Jan 10;106(3):798-804. doi: 10.4269/ajtmh.21-0973.

Sikorski MJ, Ma J, Hazen TH, Desai SN, Tupua S, Nimarota-Brown S, Sialeipata M, Rambocus S, Ballard SA, Valcanis M, Thomsen RE, Robins-Browne RM, Howden BP, Naseri TK, Levine MM, Rasko DA. Spatial-temporal and phylogenetic analyses of epidemiologic data to help understand the modes of transmission of endemic typhoid fever in Samoa. PLoS Negl Trop Dis. 2022 Oct 17;16(10):e0010348. doi: 10.1371/journal.pntd.0010348.

Sikorski MJ, Hazen TH, Desai SN, Nimarota-Brown S, Tupua S, Sialeipata M, Rambocus S, Ingle DJ, Duchene S, Ballard SA, Valcanis M, Zufan S, Ma J, Sahl JW, Maes M, Dougan G, Thomsen RE, Robins-Browne RM, Howden BP, Naseri TK, Levine MM, Rasko DA. Persistence of Rare Salmonella Typhi Genotypes Susceptible to First-Line Antibiotics in the Remote Islands of Samoa. mBio. 2022 Oct 26;13(5):e0192022. doi: 10.1128/mbio.01920-22.

Maes M, Sikorski MJ, Carey ME, Higginson EE, Dyson ZA, Fernandez A, Araya P, Tennant SM, Baker S, Lagos R, Hormazábal JC, Levine MM, Dougan G. Whole genome sequence analysis of Salmonella Typhi provides evidence of phylogenetic linkage between cases of typhoid fever in Santiago, Chile in the 1980s and 2010-2016. PLoS Negl Trop Dis. 2022 Jun 29;16(6):e0010178. doi: 10.1371/journal.pntd.0010178.

Emily Smith

Smith EM, Grassel CL, Papadimas A, Foulke-Abel J, Barry EM. The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model. PLoS Negl Trop Dis. 2022 Jul 26;16(7):e0010638. doi: 10.1371/journal.pntd.0010638.

Kieran Tebben

Tebben K, Dia A, Serre D. Determination of the Stage Composition of Plasmodium Infections from Bulk Gene Expression Data. mSystems. 2022 Aug 30;7(4):e0025822. doi: 10.1128/msystems.00258-22.

Ellis Tibbs

Tibbs E, Cao X. Murine myeloid derived suppressor cells possess a range of suppressive mechanisms-Granzyme B is not among them. Cancer Immunol Immunother. 2022 Feb 7. doi: 10.1007/s00262-022-03162-z.

Tibbs E, Cao X. Emerging Canonical and Non-Canonical Roles of Granzyme B in Health and Disease. Cancers (Basel). 2022 Mar 10;14(6):1436. doi: 10.3390/cancers14061436.

Gideon Wolf

Wolf G, Gerber AN, Fasana ZG, Rosenberg K, Singh NJ. Acute effects of FLT3L treatment on T cells in intact mice. Sci Rep. 2022 Nov 14;12(1):19487. doi: 10.1038/s41598-022-24126-4.

Brammer J, Wolf G, Baliban SM, Allen JC, Choi M, Kambouris AR, Simon R, Fiskum G, Chao W, Lopez K, Miller C, Singh NJ, Cross AS. A Nonlethal Full-Thickness Flame Burn Produces a Seroma Beneath the Forming Eschar, Thereby Promoting Pseudomonas aeruginosa Sepsis in Mice. J Burn Care Res. 2022 Jul 1;43(4):792-801. doi: 10.1093/jbcr/irab195.

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Neuroscience

Jason Alipio

Xue B, Alipio JB, Kao JPY, Kanold PO. Perinatal Opioid Exposure Results in Persistent Hypoconnectivity of Excitatory Circuits and Reduced Activity Correlations in Mouse Primary Auditory Cortex. J Neurosci. 2022 Apr 27;42(17):3676-3687. doi: 10.1523/JNEUROSCI.2542-21.2022.

Alipio JB, Riggs LM, Plank M, Keller A. Environmental Enrichment Mitigates the Long-Lasting Sequelae of Perinatal Fentanyl Exposure in Mice. J Neurosci. 2022 Apr 27;42(17):3557-3569. doi: 10.1523/JNEUROSCI.2083-21.2022.

Jamila Asgar

Arora V, Li T, Kumari S, Wang S, Asgar J, Chung MK. Capsaicin-induced depolymerization of axonal microtubules mediates analgesia for trigeminal neuropathic pain. Pain. 2022 Aug 1;163(8):1479-1488. doi: 10.1097/j.pain.0000000000002529.

Sydney Ashton-Cromwell

VanRyzin JW, Marquardt AE, Argue KJ, Vecchiarelli HA, Ashton SE, Arambula SE, Hill MN, McCarthy MM. Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play. Neuron. 2022 Apr 6;110(7):1271. doi: 10.1016/j.neuron.2022.03.013.

Garrett Bunce

McKeon PN, Bunce GW, Patton MH, Chen R, Mathur BN. Cortical control of striatal fast-spiking interneuron synchrony. J Physiol. 2022 May;600(9):2189-2202. doi: 10.1113/JP282850.

Altas B, Romanowski AJ, Bunce GW, Poulopoulos A. Neuronal mTOR Outposts: Implications for Translation, Signaling, and Plasticity. Front Cell Neurosci. 2022 Apr 7;16:853634. doi: 10.3389/fncel.2022.853634.

Christie Dionisos

Reinl EL, Blanchard AC, Graham EL, Edwards SW, Dionisos CV, McCarthy MM. The immune cell profile of the developing rat brain. Brain Behav Immun. 2022 Nov;106:198-226. doi: 10.1016/j.bbi.2022.08.012.

Soad Elziny

Iffland PH, Everett ME, Cobb-Pitstick KM, Bowser LE, Barnes AE, Babus JK, Romanowski AJ, Baybis M, Elziny S, Puffenberger EG, Gonzaga-Jauregui C, Poulopoulos A, Carson VJ, Crino PB. NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination and seizure threshold. Brain. 2022 Nov 21;145(11):3872-3885. doi: 10.1093/brain/awac044.

Daniela Franco

Siemsen BM, Franco D, Lobo MK. Corticostriatal contributions to dysregulated motivated behaviors in stress, depression, and substance use disorders. Neurosci Res. 2022 Dec 21:S0168-0102(22)00304-2. doi: 10.1016/j.neures.2022.12.014.

Franco D, Wulff AB, Lobo MK, Fox ME. Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice. Front Behav Neurosci. 2022 Feb 10;16:821080. doi: 10.3389/fnbeh.2022.821080.

Fox ME, Wulff AB, Franco D, Choi EY, Calarco CA, Engeln M, Turner MD, Chandra R, Rhodes VM, Thompson SM, Ament SA, Lobo MK. Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence. Biol Psychiatry. 2022 Aug 30:S0006-3223(22)01551-7. doi: 10.1016/j.biopsych.2022.08.023.

Pagliusi M Jr, Franco D, Cole S, Morais-Silva G, Chandra R, Fox ME, Iñiguez SD, Sartori CR, Lobo MK. The BDNF-TrkB Pathway Acts Through Nucleus Accumbens D2 Expressing Neurons to Mediate Stress Susceptible Outcomes. Front Psychiatry. 2022 Jun 2;13:854494. doi: 10.3389/fpsyt.2022.854494.

Andrew Furman

Mazaheri A, Seminowicz DA, Furman AJ. Peak alpha frequency as a candidate biomarker of pain sensitivity: the importance of distinguishing slow from slowing. Neuroimage. 2022 Nov 15;262:119560. doi: 10.1016/j.neuroimage.2022.

Lacey Greer

Greer LK, Meilleur KG, Harvey BK, Wires ES. Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells. Orphanet J Rare Dis. 2022 Jun 13;17(1):225. doi: 10.1186/s13023-022-02368-9.

Niaz Khan

Ritzel RM, Li Y, Lei Z, Carter J, He J, Choi HMC, Khan N, Li H, Allen S, Lipinski MM, Faden AI, Wu J. Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice. Geroscience. 2022 Jun;44(3):1407-1440. doi: 10.1007/s11357-022-00562-y.

Samuel Krimmel

Madden MB, Stewart BW, White MG, Krimmel SR, Qadir H, Barrett FS, Seminowicz DA, Mathur BN. A role for the claustrum in cognitive control. Trends Cogn Sci. 2022 Dec;26(12):1133-1152. doi: 10.1016/j.tics.2022.09.006.

Hunt CA, Letzen JE, Krimmel SR, Burrowes SAB, Haythornthwaite JA, Finan PH, Vetter M, Seminowicz DA. Is Mindfulness Associated With Lower Pain Reactivity and Connectivity of the Default Mode Network? A Replication and Extension Study in Healthy and Episodic Migraine Participants. J Pain. 2022 Dec;23(12):2110-2120. doi: 10.1016/j.jpain.2022.07.011.

Krimmel SR, DeSouza DD, Keaser ML, Sanjanwala BM, Cowan RP, Lindquist MA, Haythornthwaite JA, Seminowicz DA. Three Dimensions of Association Link Migraine Symptoms and Functional Connectivity. J Neurosci. 2022 Aug 3;42(31):6156-6166. doi: 10.1523/JNEUROSCI.1796-21.2022.

Xu H, Seminowicz DA, Krimmel SR, Zhang M, Gao L, Wang Y. Altered Structural and Functional Connectivity of Salience Network in Patients with Classic Trigeminal Neuralgia. J Pain. 2022 Aug;23(8):1389-1399. doi: 10.1016/j.jpain.2022.02.012.

Krimmel SR, Keaser ML, Speis D, Haythornthwaite JA, Seminowicz DA. Migraine disability, pain catastrophizing, and headache severity are associated with evoked pain and targeted by mind-body therapy. Pain. 2022 Sep 1;163(9):e1030-e1037. doi: 10.1097/j.pain.0000000000002578.

Maxwell Madden

Doss MK, Madden MB, Gaddis A, Nebel MB, Griffiths RR, Mathur BN, Barrett FS. Models of psychedelic drug action: modulation of cortical-subcortical circuits. Brain. 2022 Apr 18;145(2):441-456. doi: 10.1093/brain/awab406.

Madden MB, Stewart BW, White MG, Krimmel SR, Qadir H, Barrett FS, Seminowicz DA, Mathur BN. A role for the claustrum in cognitive control. Trends Cogn Sci. 2022 Dec;26(12):1133-1152. doi: 10.1016/j.tics.2022.09.006.

Ashley Marquardt

Baglot SL, VanRyzin JW, Marquardt AE, Aukema RJ, Petrie GN, Hume C, Reinl EL, Bieber JB, McLaughlin RJ, McCarthy MM, Hill MN. Maternal-fetal transmission of delta-9-tetrahydrocannabinol (THC) and its metabolites following inhalation and injection exposure during pregnancy in rats. J Neurosci Res. 2022 Mar;100(3):713-730. doi: 10.1002/jnr.24992.

Miriam Menken

Isaiah A, Ernst TM, Liang H, Ryan M, Cunningham E, Rodriguez PJ, Menken M, Kaschak D, Guihen C, Reeves G, Lever N, Edwards SM, Chang L. Associations between socioeconomic gradients and racial disparities in preadolescent brain outcomes. Pediatr Res. 2022 Dec 1. doi: 10.1038/s41390-022-02399-9.

Menken MS, Isaiah A, Liang H, Rivera PR, Cloak CC, Reeves G, Lever NA, Chang L. Peer victimization (bullying) on mental health, behavioral problems, cognition, and academic performance in preadolescent children in the ABCD Study. Front Psychol. 2022 Sep 26;13:925727. doi: 10.3389/fpsyg.2022.925727.

Kristen Montgomery

Cole AB, Montgomery K, Bale TL, Thompson SM. What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons. Neurobiol Stress. 2022 Aug 5;20:100473. doi: 10.1016/j.ynstr.2022.100473.

Mitchell Moyer

Ksendzovsky A, Bachani M, Altshuler M, Walbridge S, Mortazavi A, Moyer M, Chen C, Fayed I, Steiner J, Edwards N, Inati SK, Jahanipour J, Maric D, Heiss JD, Kapur J, Zaghloul KA. Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway. Brain Commun. 2022 Dec 1;5(1):fcac298. doi: 10.1093/braincomms/fcac298.

Houman Qadir

Madden MB, Stewart BW, White MG, Krimmel SR, Qadir H, Barrett FS, Seminowicz DA, Mathur BN. A role for the claustrum in cognitive control. Trends Cogn Sci. 2022 Dec;26(12):1133-1152. doi: 10.1016/j.tics.2022.09.006.

Qadir H, Stewart BW, VanRyzin JW, Wu Q, Chen S, Seminowicz DA, Mathur BN. The mouse claustrum synaptically connects cortical network motifs. Cell Rep. 2022 Dec 20;41(12):111860. doi: 10.1016/j.celrep.2022.111860.

Engeln M, Fox ME, Chandra R, Choi EY, Nam H, Qadir H, Thomas SS, Rhodes VM, Turner MD, Herman RJ, Calarco CA, Lobo MK. Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward. Mol Psychiatry. 2022 Oct;27(10):3980-3991. doi: 10.1038/s41380-022-01668-7.

Lace Riggs

Riggs LM, Thompson SM, Gould TD. (2R,6R)-hydroxynorketamine rapidly potentiates optically-evoked Schaffer collateral synaptic activity. Neuropharmacology. 2022 Aug 15;214:109153. doi: 10.1016/j.neuropharm.2022.109153.

Hasin N, Riggs LM, Shekhtman T, Ashworth J, Lease R, Oshone RT, Humphries EM, Badner JA, Thomson PA, Glahn DC, Craig DW, Edenberg HJ, Gershon ES, McMahon FJ, Nurnberger JI, Zandi PP, Kelsoe JR, Roach JC, Gould TD, Ament SA. Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder. Mol Psychiatry. 2022 Sep;27(9):3842-3856. doi: 10.1038/s41380-022-01609-4.

Alipio JB, Riggs LM, Plank M, Keller A. Environmental Enrichment Mitigates the Long-Lasting Sequelae of Perinatal Fentanyl Exposure in Mice. J Neurosci. 2022 Apr 27;42(17):3557-3569. doi: 10.1523/JNEUROSCI.2083-21.2022.

Highland JN, Morris PJ, Konrath KM, Riggs LM, Hagen NR, Zanos P, Powels CF, Moaddel R, Thomas CJ, Wang AQ, Gould TD. Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines. ACS Chem Neurosci. 2022 Feb 16;13(4):510-523. doi: 10.1021/acschemneuro.1c00761.

Hess EM, Riggs LM, Michaelides M, Gould TD. Mechanisms of ketamine and its metabolites as antidepressants. Biochem Pharmacol. 2022 Mar;197:114892. doi: 10.1016/j.bcp.2021.114892.

Colin Robertson

Hariharan A, Robertson CD, Garcia DCG, Longden TA. Brain capillary pericytes are metabolic sentinels that control blood flow through a K_ATP channel-dependent energy switch. Cell Rep. 2022 Dec 27;41(13):111872. doi: 10.1016/j.celrep.2022.111872.

Pedro Rodriguez Rivera

Menken MS, Isaiah A, Liang H, Rivera PR, Cloak CC, Reeves G, Lever NA, Chang L. Peer victimization (bullying) on mental health, behavioral problems, cognition, and academic performance in preadolescent children in the ABCD Study. Front Psychol. 2022 Sep 26;13:925727. doi: 10.3389/fpsyg.2022.925727.

Meghann Ryan

Isaiah A, Ernst TM, Liang H, Ryan M, Cunningham E, Rodriguez PJ, Menken M, Kaschak D, Guihen C, Reeves G, Lever N, Edwards SM, Chang L. Associations between socioeconomic gradients and racial disparities in preadolescent brain outcomes. Pediatr Res. 2022 Dec 1. doi: 10.1038/s41390-022-02399-9.

Ryan MC, Hong LE, Hatch KS, Gao S, Chen S, Haerian K, Wang J, Goldwaser EL, Du X, Adhikari BM, Bruce H, Hare S, Kvarta MD, Jahanshad N, Nichols TE, Thompson PM, Kochunov P. The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging. Hum Brain Mapp. 2022 Apr 15;43(6):1997-2010. doi: 10.1002/hbm.25769.

Kochunov P, Fan F, Ryan MC, Hatch KS, Tan S, Jahanshad N, Thompson PM, van Erp TGM, Turner JA, Chen S, Du X, Adhikari B, Bruce H, Hare S, Goldwaser E, Kvarta M, Huang J, Tong J, Cui Y, Cao B, Tan Y, Hong LE. Translating ENIGMA schizophrenia findings using the regional vulnerability index: Association with cognition, symptoms, and disease trajectory. Hum Brain Mapp. 2022 Jan;43(1):566-575. doi: 10.1002/hbm.25045.

Kochunov P, Hong LE, Dennis EL, Morey RA, Tate DF, Wilde EA, Logue M, Kelly S, Donohoe G, Favre P, Houenou J, Ching CRK, Holleran L, Andreassen OA, van Velzen LS, Schmaal L, Villalón-Reina JE, Bearden CE, Piras F, Spalletta G, van den Heuvel OA, Veltman DJ, Stein DJ, Ryan MC, Tan Y, van Erp TGM, Turner JA, Haddad L, Nir TM, Glahn DC, Thompson PM, Jahanshad N. ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research. Hum Brain Mapp. 2022 Jan;43(1):194-206. doi: 10.1002/hbm.24998.

Kelson Shilling-Scrivo

Shilling-Scrivo K, Mittelstadt J, Kanold PO. Decreased Modulation of Population Correlations in Auditory Cortex Is Associated with Decreased Auditory Detection Performance in Old Mice. J Neurosci. 2022 Dec 7;42(49):9278-9292. doi: 10.1523/JNEUROSCI.0955-22.2022.

Brent Stewart

Georgiou P, Zanos P, Mou TM, An X, Gerhard DM, Dryanovski DI, Potter LE, Highland JN, Jenne CE, Stewart BW, Pultorak KJ, Yuan P, Powels CF, Lovett J, Pereira EFR, Clark SM, Tonelli LH, Moaddel R, Zarate CA Jr, Duman RS, Thompson SM, Gould TD. Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor. Nat Neurosci. 2022 Sep;25(9):1191-1200. doi: 10.1038/s41593-022-01146-x.

Madden MB, Stewart BW, White MG, Krimmel SR, Qadir H, Barrett FS, Seminowicz DA, Mathur BN. A role for the claustrum in cognitive control. Trends Cogn Sci. 2022 Dec;26(12):1133-1152. doi: 10.1016/j.tics.2022.09.006.

Qadir H, Stewart BW, VanRyzin JW, Wu Q, Chen S, Seminowicz DA, Mathur BN. The mouse claustrum synaptically connects cortical network motifs. Cell Rep. 2022 Dec 20;41(12):111860. doi: 10.1016/j.celrep.2022.111860.

Andreas Wulff

Fox ME, Wulff AB, Franco D, Choi EY, Calarco CA, Engeln M, Turner MD, Chandra R, Rhodes VM, Thompson SM, Ament SA, Lobo MK. Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence. Biol Psychiatry. 2022 Aug 30:S0006-3223(22)01551-7. doi: 10.1016/j.biopsych.2022.08.023.

Franco D, Wulff AB, Lobo MK, Fox ME. Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice. Front Behav Neurosci. 2022 Feb 10;16:821080. doi: 10.3389/fnbeh.2022.821080.

Naibo Zhang

Bordt EA, Zhang N, Waddell J, Polster BM. The Non-Specific Drp1 Inhibitor Mdivi-1 Has Modest Biochemical Antioxidant Activity. Antioxidants (Basel). 2022 Feb 24;11(3):450. doi: 10.3390/antiox11030450.

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Physical Rehabilitation Science

Nesreen Alissa

Jeon W, Whitall J, Alissa N, Westlake K. Age-related differences in stepping stability following a sudden gait perturbation are associated with lower limb eccentric control of the perturbed limb. Exp Gerontol. 2022 Oct 1;167:111917. doi: 10.1016/j.exger.2022.111917.

Kathleen Dondero

Landers-Ramos RQ, Dondero K, Nelson C, Ranadive SM, Prior SJ, Addison O. Muscle thickness and inflammation during a 50km ultramarathon in recreational runners. PLoS One. 2022 Sep 1;17(9):e0273510. doi: 10.1371/journal.pone.0273510.

Landers-Ramos RQ, Lawal I, Imery I, Siok D, Addison O, Zabriskie HA, Dondero K, Dobrosielski DA. High-intensity functional exercise does not cause persistent elevations in augmentation index in young men and women. Appl Physiol Nutr Metab. 2022 Sep 1;47(9):963-972. doi: 10.1139/apnm-2022-0081.

Dondero KR, Falvey JR, Beamer BA, Addison O. Geriatric Vulnerabilities Among Obese Older Adults With and Without Sarcopenia: Findings From a Nationally Representative Cohort Study. J Geriatr Phys Ther. 2022 Aug 18. doi: 10.1519/JPT.0000000000000358.

Simon Ho

Ho S, Rock K, Addison O, Marchese V. Relationships between diaphragm ultrasound, spirometry, and respiratory mouth pressures in children. Respir Physiol Neurobiol. 2022 Nov;305:103950. doi: 10.1016/j.resp.2022.103950.

Ho S, Culligan M, Friedberg J, Goloubeva O, Marchese V. Examining the impact of physical function performance in predicting patient outcomes after lung-sparing surgery for malignant pleural mesothelioma. Disabil Rehabil. 2022 Nov;44(22):6676-6683. doi: 10.1080/09638288.2021.1970256.

Ho S, York T, Marchese V. Exploring relationships between inspiratory muscle strength and functional capacity in childhood cancer survivors: a pilot study. Pediatr Hematol Oncol. 2022 Apr;39(3):203-214. doi: 10.1080/08880018.2021.1960656.

Sarah Margerison

Margerison SM, Westlake KP, Seminowicz DA. Beyond pain in the brain: A clinician's guide to interpreting the spinal cord's role in the pain experience. Musculoskelet Sci Pract. 2022 Dec;62:102664. doi: 10.1016/j.msksp.2022.102664.

Kelly Rock

Marchese V, Rock K, Harpold A, Salazar A, Williams M, Shipper AG. Physical Impairment and Function in Children and Adolescents With Sickle Cell Disease: A Systematic Review. Arch Phys Med Rehabil. 2022 Jun;103(6):1144-1167.e2. doi: 10.1016/j.apmr.2021.08.022.

Ho S, Rock K, Addison O, Marchese V. Relationships between diaphragm ultrasound, spirometry, and respiratory mouth pressures in children. Respir Physiol Neurobiol. 2022 Nov;305:103950. doi: 10.1016/j.resp.2022.103950.

Marchese V, Rock K, York T, Ruble K, Gray VL. The Efficacy of Targeted Exercise on Gross Motor and Neuromuscular Performance in Survivors of Childhood Leukemia: A Pilot Study. Front Pediatr. 2022 May 11;10:891650. doi: 10.3389/fped.2022.891650.

Lanza MB, Rock K, Marchese V, Gray VL, Addison O. Ultrasound measures of muscle thickness and subcutaneous tissue from the hip abductors: Inter- and intra-rater reliability. Musculoskelet Sci Pract. 2022 Dec;62:102612. doi: 10.1016/j.msksp.2022.102612.

Rock K, Addison O, Gray VL, Nelson CM, Henshaw RM, York T, Ruble K, Marchese V. Quantifying muscle strength, size, and neuromuscular activation in adolescent and young adult survivors of musculoskeletal sarcoma: Identifying correlates and responses to functional strengthening. Knee. 2022 Dec 16;40:270-282. doi: 10.1016/j.knee.2022.11.024.

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