2024 Publications

Adedola Abebamowo

Mentor: Nevil J. Singh, PhD

Boughter CT, Chatterjee B, Ohta Y, Gorga K, Blair C, Hill EM, Fasana Z, Adebamowo A, Ammar F, Kosik I, Murugan V, Chen WH, Singh NJ, Meier-Schellersheim M. CountASAP: A Lightweight, Easy to Use Python Package for Processing ASAPseq Data. bioRxiv [Preprint]. 2024 May 22:2024.05.20.595042. doi: 10.1101/2024.05.20.595042. PMID: 38903111; PMCID: PMC11188107.

Emmanuel B. Asiedu

Mentor: Silvia V. Montaner, PhD, MPH

Kumar A, Asiedu E, Hefni E, Armstrong C, Menon D, Ma T, Sands L, Mbadugha E, Sodhi A, Schneider A, Montaner S. Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma. J Oral Pathol Med. 2024 May 19. doi: 10.1111/jop.13545. Epub ahead of print. PMID: 38763759.

Daniel D. Garman

Mentor: Robert J. Bloch, PhD

Muriel J, Lukyanenko V, Kwiatkowski TA, Li Y, Bhattacharya S, Banford KK, Garman D, Bulgart HR, Sutton RB, Weisleder N, Bloch RJ. Nanodysferlins support membrane repair and binding to TRIM72/MG53 but do not localize to t-tubules or stabilize Ca2+ signaling. Mol Ther Methods Clin Dev. 2024 Apr 26;32(2):101257. doi: 10.1016/j.omtm.2024.101257. PMID: 38779337; PMCID: PMC11109471.

Aishwarya Iyer

Mentor: Aikaterini Kontrogianni-Konstantopoulos, PhD

Iyer A, Lauerova B, Mariano J, Haberlová J, Lassuthova P, Zidkova J, Wright NT, Kontrogianni-Konstantopoulos A. Compound heterozygous variants in MYBPC1 lead to severe distal arthrogryposis type-1 manifestations. Gene. 2024 Jun 5;910:148339. doi: 10.1016/j.gene.2024.148339. Epub 2024 Mar 2. PMID: 38438057; PMCID: PMC10981553.

Yi Li

Mentor: Robert J. Bloch, PhD

Muriel J, Lukyanenko V, Kwiatkowski TA, Li Y, Bhattacharya S, Banford KK, Garman D, Bulgart HR, Sutton RB, Weisleder N, Bloch RJ. Nanodysferlins support membrane repair and binding to TRIM72/MG53 but do not localize to t-tubules or stabilize Ca2+ signaling. Mol Ther Methods Clin Dev. 2024 Apr 26;32(2):101257. doi: 10.1016/j.omtm.2024.101257. PMID: 38779337; PMCID: PMC11109471.

Jennifer M. Mariano

Mentor: Aikaterini Kontrogianni-Konstantopoulos, PhD

Iyer A, Lauerova B, Mariano J, Haberlová J, Lassuthova P, Zidkova J, Wright NT, Kontrogianni-Konstantopoulos A. Compound heterozygous variants in MYBPC1 lead to severe distal arthrogryposis type-1 manifestations. Gene. 2024 Jun 5;910:148339. doi: 10.1016/j.gene.2024.148339. Epub 2024 Mar 2. PMID: 38438057; PMCID: PMC10981553.

Ian P. O'Keefe

Mentor: Robert K. Ernst, PhD

Hofstaedter CE, O'Keefe IP, Met CM, Wu L, Vanderwoude J, Shin S, Diggle SP, Riquelme SA, Rasko DA, Doi Y, Harro JM, Kopp BT, Ernst RK. Pseudomonas aeruginosa Lipid A Structural Variants Induce Altered Immune Responses. Am J Respir Cell Mol Biol. 2024 Apr 24. doi: 10.1165/rcmb.2024-0059OC. Epub ahead of print. PMID: 38656811.

Gloria M. Patron Fidalgo

Mentor: Gerald M. Wilson, PhD

Colloca L, Mocci E, Wang Y, Massalee R, Chen S, White J, Johnson K, Patron Fidalgo GM, Wilson GM, Goldman D, Dorsey SG. Transcriptomic Profiles Associated with Experimental Placebo Effects in Chronic Pain. Clin Pharmacol Ther. 2024 May 6. doi: 10.1002/cpt.3286. Epub ahead of print. PMID: 38711244.

Spiridon E. Sevdalis

Mentor: David J. Weber, PhD

Abeyawardhane DL, Sevdalis SE, Adipietro KA, Godoy-Ruiz R, Varney KM, Nawaz IF, Spittel AX, Rustandi RR, Silin VI, des Georges A, Pozharski E, Weber DJ. Membrane binding and pore formation is Ca ²⁺ -dependent for the Clostridioides difficile binary toxin. bioRxiv [Preprint]. 2023 Sep 21:2023.08.18.553786. doi: 10.1101/2023.08.18.553786. PMID: 37645845; PMCID: PMC10462154.

Megan B. Stemberger

Mentor: Stuart S. Martin, PhD

Smith IM, Ursitti JA, Majeti P, Givpoor N, Stemberger MB, Hengen A, Banerjee S, Stains J, Martin SS, Ward C, Stroka KM. High throughput cell mechanotyping of cell response to cytoskeletal modulations using a microfluidic cell deformation system. bioRxiv [Preprint]. 2024 Jun 19:2024.06.17.599307. doi: 10.1101/2024.06.17.599307. PMID: 38948841; PMCID: PMC11212920.

Mull ML, Pratt SJP, Thompson KN, Annis DA, Gad AA, Lee RM, Chang KT, Stemberger MB, Ju JA, Gilchrist DE, Boyman L, Vitolo MI, Lederer WJ, Martin SS. Disruption of P2Y2 signaling promotes breast tumor cell dissemination by reducing ATP-dependent calcium elevation and actin localization to cell junctions. bioRxiv [Preprint]. 2024 Jun 13:2023.03.31.533191. doi: 10.1101/2023.03.31.533191. PMID: 37034765; PMCID: PMC10081304.

Amando Strong

Mentor: Toni M. Antalis, PhD

Pawar NR, Buzza MS, Duru N, Strong AA, Antalis TM. Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis. J Cell Biol. 2023 Nov 6;222(11):e202209114. doi: 10.1083/jcb.202209114. Epub 2023 Sep 22. PMID: 37737895; PMCID: PMC10515437.

Matthew G. Adams

Mentor: Shannon Takala-Harrison, PhD

Chou RT, Ouattara A, Adams M, Berry AA, Takala-Harrison S, Cummings MP. Positive-unlabeled learning identifies vaccine candidate antigens in the malaria parasite Plasmodium falciparum. NPJ Syst Biol Appl. 2024 Apr 27;10(1):44. doi: 10.1038/s41540-024-00365-1. PMID: 38678051; PMCID: PMC11055854.

Vareta J, Horstman NA, Adams M, Seydel KB, McCann RS, Cohee LM, Laufer MK, Takala-Harrison S. Genotyping Plasmodium falciparum gametocytes using amplicon deep sequencing. Malar J. 2024 Apr 6;23(1):96. doi: 10.1186/s12936-024-04920-3. PMID: 38582837; PMCID: PMC10999092.

Aung PP, Han KT, Groot W, Biesma R, Thein ZW, Htay T, Lin Z, Aye KH, Adams M, Pavlova M. Heterogeneity in the prevalence of subclinical malaria, other co-infections and anemia among pregnant women in rural areas of Myanmar: a community-based longitudinal study. Trop Med Health. 2024 Mar 8;52(1):22. doi: 10.1186/s41182-024-00577-5. PMID: 38459581; PMCID: PMC10921590.

Tewey MA, Coulibaly D, Lawton JG, Stucke EM, Zhou AE, Berry AA, Bailey JA, Pike A, Dara A, Ouattara A, Lyke KE, Ifeonu O, Laurens MB, Adams M, Takala-Harrison S, Niangaly A, Kouriba B, Koné AK, Rowe JA, Doumbo OK, Patel JJ, Tan JC, Felgner PL, Plowe CV, Thera MA, Travassos MA. Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s. mSphere. 2023 Oct 24;8(5):e0045123. doi: 10.1128/msphere.00451-23. Epub 2023 Oct 4. PMID: 37791774; PMCID: PMC10597466.

Liana R. Andronescu

Mentor: Miriam K. Laufer, MD

Andronescu LR, Buchwald AG, Sharma A, Bauleni A, Mawindo P, Liang Y, Gutman JR, Mathanga DP, Chinkhumba J, Laufer MK. Plasmodium falciparum infection and disease in infancy associated with increased risk of malaria and anaemia in childhood. Malar J. 2023 Jul 26;22(1):217. doi: 10.1186/s12936-023-04646-8. PMID: 37496052; PMCID: PMC10369742.

Florence O. Bada

Mentors: Kristen A. Stafford, PhD, MPH and James D. Campbell, MD, MS

Jumare J, Dakum P, Sam-Agudu N, Memiah P, Nowak R, Bada F, Oguama U, Odonye G, Adebiyi R, Cairo C, Kwaghe V, Adebamowo C, Abimiku A, Charurat M. Prevalence and characteristics of metabolic syndrome and its components among adults living with and without HIV in Nigeria: a single-center study. BMC Endocr Disord. 2023 Jul 28;23(1):160. doi: 10.1186/s12902-023-01419-x. PMID: 37507703; PMCID: PMC10375691.

Salma A. Bargal

Mentor: Amber L. Beitelshees, PharmD, MPH

Shahidzadeh Yazdi Z, Streeten EA, Whitlatch HB, Bargal SA, Beitelshees AL, Taylor SI. Value of Vitamin D Metabolite Ratios in 3 Patients as Diagnostic Criteria to Assess Vitamin D Status. JCEM Case Rep. 2024 Jun 28;2(7):luae095. doi: 10.1210/jcemcr/luae095. PMID: 38947416; PMCID: PMC11211852.

Sarah E. Brown

Mentor: Rebecca M. Brotman, MPH, PhD

Stennett CA, France M, Shardell M, Robbins SJ, Brown SE, Johnston ED, Mark K, Ravel J, Brotman RM. Longitudinal profiles of the vaginal microbiota of pre-, peri-, and postmenopausal women: preliminary insights from a secondary data analysis. Menopause. 2024 Jun 1;31(6):537-545. doi: 10.1097/GME.0000000000002358. PMID: 38787353.

Robbins SJ, Brown SE, Stennett CA, Tuddenham S, Johnston ED, Wnorowski AM, Ravel J, He X, Mark KS, Brotman RM. Uterine fibroids and longitudinal profiles of the vaginal microbiota in a cohort presenting for transvaginal ultrasound. PLoS One. 2024 Feb 5;19(2):e0296346. doi: 10.1371/journal.pone.0296346. PMID: 38315688; PMCID: PMC10843103.

Klasner C, Macintyre AN, Brown SE, Bavoil P, Ghanem KG, Nylander E, Ravel J, Tuddenham S, Brotman RM. A Narrative Review on Spontaneous Clearance of Urogenital Chlamydia trachomatis: Host, Microbiome, and Pathogen-Related Factors. Sex Transm Dis. 2024 Feb 1;51(2):112-117. doi: 10.1097/OLQ.0000000000001905. Epub 2023 Nov 25. PMID: 38290156.

Brown SE, Brotman RM. Letter to the Editor on "A randomized trial on the effectiveness and safety of 5 water-based personal lubricants". J Sex Med. 2023 Oct 3;20(10):1257. doi: 10.1093/jsxmed/qdad077. PMID: 37553097; PMCID: PMC10545533.

Brown SE, Tuddenham S, Shardell MD, Klebanoff MA, Ghanem KG, Brotman RM. Bacterial Vaginosis and Spontaneous Clearance of Chlamydia trachomatis in the Longitudinal Study of Vaginal Flora. J Infect Dis. 2023 Sep 15;228(6):783-791. doi: 10.1093/infdis/jiad142. PMID: 37158693; PMCID: PMC10503950.

Kimberly C. Claeys

Mentor: Daniel J. Morgan, MD, MS

Claeys KC, Morgan DJ, Johnson MD. The importance of pharmacist engagement in diagnostic stewardship. Antimicrob Steward Healthc Epidemiol. 2024 Apr 16;4(1):e43. doi: 10.1017/ash.2024.34. PMID: 38628377; PMCID: PMC11019581.

Singh HK, Claeys KC, Advani SD, Ballam YJ, Penney J, Schutte KM, Baliga C, Milstone AM, Hayden MK, Morgan DJ, Diekema DJ. Diagnostic stewardship to improve patient outcomes and healthcare-associated infection (HAI) metrics. Infect Control Hosp Epidemiol. 2024 Apr;45(4):405-411. doi: 10.1017/ice.2023.284. Epub 2024 Jan 11. PMID: 38204365; PMCID: PMC11007360.

Coffey KC, Morgan DJ, Claeys KC. Diagnostic stewardship: what impacts antibiotics use? Curr Opin Infect Dis. 2023 Aug 1;36(4):270-275. doi: 10.1097/QCO.0000000000000927. Epub 2023 Jun 19. PMID: 37431556.

Morgan DJ, Leekha S, Claeys KC. Increasing Evidence That Diagnostic Stewardship May Improve Antibiotic Use. JAMA Intern Med. 2023 Sep 1;183(9):942-943. doi: 10.1001/jamainternmed.2023.2756. PMID: 37428497.

Claeys KC, Weston LE, Pineles L, Morgan DJ, Krein SL. Implementing diagnostic stewardship to improve diagnosis of urinary tract infections across three medical centers: A qualitative assessment. Infect Control Hosp Epidemiol. 2023 Dec;44(12):1932-1941. doi: 10.1017/ice.2023.106. Epub 2023 Jul 10. PMID: 37424224; PMCID: PMC10776821.

James A. Cottam

Mentor: Luana Colloca, MD, PhD

O'Hara LM, Harris AD, Calfee DP, Snyder GM, Cottam J, O'Hara NN, Martin EM. Healthcare personnel opinions regarding the feasibility of a risk-tailored approach to contact precautions for methicillin-resistant Staphylococcus aureus in the acute care setting. Infect Control Hosp Epidemiol. 2024 Apr 22:1-3. doi: 10.1017/ice.2024.54. Epub ahead of print. PMID: 38646712.

Jennifer N. French

Mentor: Timothy D. O'Connor, PhD

French JN, Pua VB, Laboulaye R, Leal TP, Olivas MC, Lima-Costa MF, Horta BL, Barreto ML, Tarazona-Santos E, Mata I, O'Connor TD. Comparing the effect of imputation reference panel composition in four distinct Latin American cohorts. bioRxiv [Preprint]. 2024 Apr 15:2024.04.11.589057. doi: 10.1101/2024.04.11.589057. PMID: 38659746; PMCID: PMC11042191.

Leal TP, Rao SC, French-Kwawu JN, Gouveia MH, Borda V, Bandres-Ciga S, Inca-Martinez M, Mason EA, Horimoto ARVR, Loesch DP, Sarihan EI, Cornejo-Olivas MR, Torres LE, Mazzetti-Soler PE, Cosentino C, Sarapura-Castro EH, Rivera-Valdivia A, Medina AC, Dieguez EM, Raggio VE, Lescano A, Tumas V, Borges V, Ferraz HB, Rieder CR, Schumacher Schuh A, Santos-Lobato BL, Velez-Pardo C, Jimenez-Del-Rio M, Lopera F, Moreno S, Chana-Cuevas P, Fernandez W, Arboleda G, Arboleda H, Arboleda Bustos CE, Yearout D, Barbosa MT, Cardoso FEC, Caramelli P, Cunningham MCQ, Maia DP, Lima-Costa MF, Tarazona-Santos E, Zabetian CP; International Parkinson Disease Genomics Consortium (IPDGC); Thornton TA, O'Connor TD, Mata IF; Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD). X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease. Mov Disord. 2023 Sep;38(9):1625-1635. doi: 10.1002/mds.29508. Epub 2023 Jul 20. PMID: 37469269; PMCID: PMC10524402.

Leal TP, French-Kwawu JN, Gouveia MH, Borda V, Inca-Martinez M, Mason EA, Horimoto AR, Loesch DP, Sarihan EI, Cornejo-Olivas MR, Torres LE, Mazzetti-Soler PE, Cosentino C, Sarapura-Castro EH, Rivera-Valdivia A, Medina AC, Dieguez EM, Raggio VE, Lescano A, Tumas V, Borges V, Ferraz HB, Rieder CR, Schumacher-Schuh A, Santos-Lobato BL, Velez-Pardo C, Jimenez-Del-Rio M, Lopera F, Moreno S, Chana-Cuevas P, Fernandez W, Arboleda G, Arboleda H, Arboleda Bustos CE, Yearout D, Lima-Costa MF, Tarazona E, Zabetian C, Thornton TA, O'Connor TD, Mata IF. X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson Disease. medRxiv [Preprint]. 2023 Feb 2:2023.01.31.23285199. doi: 10.1101/2023.01.31.23285199. Update in: Mov Disord. 2023 Jul 20;: PMID: 36778409; PMCID: PMC9915833.

Tsion Girmay

Mentor: Joanna M. Gaitens, PhD, MSN, MPH

Patel PD, Liang Y, Meiring JE, Chasweka N, Patel P, Misiri T, Mwakiseghile F, Wachepa R, Banda HC, Shumba F, Kawalazira G, Dube Q, Nampota-Nkomba N, Nyirenda OM, Girmay T, Datta S, Jamka LP, Tracy JK, Laurens MB, Heyderman RS, Neuzil KM, Gordon MA; TyVAC team. Efficacy of typhoid conjugate vaccine: final analysis of a 4-year, phase 3, randomised controlled trial in Malawian children. Lancet. 2024 Feb 3;403(10425):459-468. doi: 10.1016/S0140-6736(23)02031-7. Epub 2024 Jan 25. PMID: 38281499; PMCID: PMC10850983.

Ouedraogo A, Diarra A, Nébié I, Barry N, Kabore JM, Tiono AB, Datta S, Liang Y, Mayo I, Oshinsky JJ, Tracy JK, Girmay T, Pasetti MF, Jamka LP, Neuzil KM, Sirima SB, Laurens MB. Durable Anti-Vi IgG and IgA Antibody Responses in 15-Month-Old Children Vaccinated With Typhoid Conjugate Vaccine in Burkina Faso. J Pediatric Infect Dis Soc. 2023 Sep 27;12(9):513-518. doi: 10.1093/jpids/piad058. PMID: 37589596; PMCID: PMC10533206.

Bing Guo

Mentor: Timothy D. O'Connor, PhD

Guo B, Takala-Harrison S, O'Connor TD. Benchmarking and Optimization of Methods for the Detection of Identity-By-Descent in Plasmodium falciparum. bioRxiv [Preprint]. 2024 May 5:2024.05.04.592538. doi: 10.1101/2024.05.04.592538. PMID: 38746392; PMCID: PMC11092787.

Guo B, Borda V, Laboulaye R, Spring MD, Wojnarski M, Vesely BA, Silva JC, Waters NC, O'Connor TD, Takala-Harrison S. Strong positive selection biases identity-by-descent-based inferences of recent demography and population structure in Plasmodium falciparum. Nat Commun. 2024 Mar 20;15(1):2499. doi: 10.1038/s41467-024-46659-0. PMID: 38509066; PMCID: PMC10954658.

Laban M, Chen X, Guo B. Unmasking the Hypoxia Landscape in Cervical Cancer: S100A2 and Its Implication for Immunotherapy Resistance. Reprod Sci. 2024 Jan;31(1):96-98. doi: 10.1007/s43032-023-01336-3. Epub 2023 Aug 31. PMID: 37653224; PMCID: PMC10784362.

Kathleen Gwilliam

Mentor: Ronna P. Hertzano, MD, PhD

Gwilliam K, Sperber M, Perry K, Rose KP, Ginsberg L, Paladugu N, Song Y, Milon B, Elkon R, Hertzano R. A cell type-specific approach to elucidate the role of miR-96 in inner ear hair cells. Front Audiol Otol. 2024;2:1400576. doi: 10.3389/fauot.2024.1400576. Epub 2024 May 9. PMID: 38826689; PMCID: PMC11141775.

Shisi He

Mentor: Braxton D. Mitchell, PhD, MPH

He S, Barry KH, Mitchell BD, Chen S, Zhang Y, Beane Freeman LE, Berndt SI. A Linear Relationship between the Number of Cancers among First-Degree Relatives and the Risk of Multiple Primary Cancers. Cancer Prev Res (Phila). 2024 Jun 28:OF1-OF7. doi: 10.1158/1940-6207.CAPR-24-0062. Epub ahead of print. PMID: 38940339.

Elizabeth M. Humphries

Mentor: Seth A. Ament, PhD

Smolyak D, Humphries EM, Parikh A, Gopalakrishnan M, Aycan F, Bjarnadóttir M, Ament SA, El-Metwally D, Beitelshees A, Agarwal R. Predicting Heterogeneity in Patient Response to Morphine Treatment for Neonatal Opioid Withdrawal Syndrome. Clin Pharmacol Ther. 2023 Nov;114(5):1015-1022. doi: 10.1002/cpt.3007. Epub 2023 Jul 31. PMID: 37470135.

Humphries EM, Ahn K, Kember RL, Lopes FL, Mocci E, Peralta JM, Blangero J, Glahn DC, Goes FS, Zandi PP, Kochunov P, Van Hout C, Shuldiner AR, Pollin TI, Mitchell BD, Bucan M, Hong LE, McMahon FJ, Ament SA. Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population. Mol Psychiatry. 2023 Dec;28(12):5262-5271. doi: 10.1038/s41380-023-02014-1. Epub 2023 Mar 7. PMID: 36882501; PMCID: PMC10483025.

Gulam Muhammed Al Kibria

Mentor: Jon M. Hirshon, MD, MPH, PhD

Kibria GMA, Albrecht J, Lane W, Stafford KA, Jones L, Vesselinov R, Hirshon JM. Prevalence, trends, and factors associated with maternal autonomy regarding healthcare, finances, and mobility in Bangladesh: Analysis of Demographic and Health Surveys 1999-2018. PLOS Glob Public Health. 2024 Feb 2;4(2):e0002816. doi: 10.1371/journal.pgph.0002816. PMID: 38306319; PMCID: PMC10836669.

Jonathan Lawton

Mentor: Mark A. Travassos, MD, MSc

Stucke EM, Lawton JG, Travassos MA. ApoE: A new piece to the severe malaria puzzle. Pediatr Res. 2024 Feb 22. doi: 10.1038/s41390-024-03096-5. Epub ahead of print. PMID: 38388820.

Tewey MA, Coulibaly D, Lawton JG, Stucke EM, Zhou AE, Berry AA, Bailey JA, Pike A, Dara A, Ouattara A, Lyke KE, Ifeonu O, Laurens MB, Adams M, Takala-Harrison S, Niangaly A, Kouriba B, Koné AK, Rowe JA, Doumbo OK, Patel JJ, Tan JC, Felgner PL, Plowe CV, Thera MA, Travassos MA. Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s. mSphere. 2023 Oct 24;8(5):e0045123. doi: 10.1128/msphere.00451-23. Epub 2023 Oct 4. PMID: 37791774; PMCID: PMC10597466.

Lavoie MC, Ehoche A, Blanco N, Ahmed El-Imam I, Oladipo A, Dalhatu I, Odafe S, Adebajo S, Ng AH, Rapoport L, Lawton JG, Obanubi C, Onotu D, Patel S, Ikpeazu A, Ashefor G, Adebobola B, Adetinuke Boyd M, Aliyu G, Stafford KA. Effect of Test and Treat on clinical outcomes in Nigeria: A national retrospective study. PLoS One. 2023 Aug 22;18(8):e0284847. doi: 10.1371/journal.pone.0284847. PMID: 37607206; PMCID: PMC10443836.

Douglas P. Loesch

Mentor: Timothy D. O'Connor, PhD

Leal TP, Rao SC, French-Kwawu JN, Gouveia MH, Borda V, Bandres-Ciga S, Inca-Martinez M, Mason EA, Horimoto ARVR, Loesch DP, Sarihan EI, Cornejo-Olivas MR, Torres LE, Mazzetti-Soler PE, Cosentino C, Sarapura-Castro EH, Rivera-Valdivia A, Medina AC, Dieguez EM, Raggio VE, Lescano A, Tumas V, Borges V, Ferraz HB, Rieder CR, Schumacher Schuh A, Santos-Lobato BL, Velez-Pardo C, Jimenez-Del-Rio M, Lopera F, Moreno S, Chana-Cuevas P, Fernandez W, Arboleda G, Arboleda H, Arboleda Bustos CE, Yearout D, Barbosa MT, Cardoso FEC, Caramelli P, Cunningham MCQ, Maia DP, Lima-Costa MF, Tarazona-Santos E, Zabetian CP; International Parkinson Disease Genomics Consortium (IPDGC); Thornton TA, O'Connor TD, Mata IF; Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD). X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease. Mov Disord. 2023 Sep;38(9):1625-1635. doi: 10.1002/mds.29508. Epub 2023 Jul 20. PMID: 37469269; PMCID: PMC10524402.

Saleha Z. Munir

Mentor: Bennie H. Jeng, MD

Stein JD, Zhou Y, Andrews CA, Kim JE, Addis V, Bixler J, Grove N, McMillan B, Munir SZ, Pershing S, Schultz JS, Stagg BC, Wang SY, Woreta F; SOURCE Consortium. Using Natural Language Processing to Identify Different Lens Pathology in Electronic Health Records. Am J Ophthalmol. 2024 Jun;262:153-160. doi: 10.1016/j.ajo.2024.01.030. Epub 2024 Feb 1. PMID: 38296152; PMCID: PMC11098689.

Wang SY, Ravindranath R, Stein JD; SOURCE Consortium. Prediction Models for Glaucoma in a Multicenter Electronic Health Records Consortium: The Sight Outcomes Research Collaborative. Ophthalmol Sci. 2023 Dec 6;4(3):100445. doi: 10.1016/j.xops.2023.100445. PMID: 38317869; PMCID: PMC10838906.

Lin AN, Mohammed ISK, Munir WM, Munir SZ, Maripudi S, Wei L, Alexander JL. Repeatability and reliability of semi-automated anterior segment-optical coherence tomography imaging compared to manual analysis in normal and keratoconus eyes. Int Ophthalmol. 2023 Dec;43(12):5063-5069. doi: 10.1007/s10792-023-02909-6. Epub 2023 Oct 24. PMID: 37874439.

Munir SZ, Munir WM. Association Between Socioeconomic Deprivation and Orbital Trauma in a Hospital-Based Population. Ophthalmic Epidemiol. 2024 Jun;31(3):210-219. doi: 10.1080/09286586.2023.2225590. Epub 2023 Jun 18. PMID: 37332246.

Gita Nadimpalli

Mentor: Anthony D. Harris, MD, MPH

DuBose B, Tembunde Y, Goodman KE, Pineles L, Nadimpalli G, Baghdadi JD, Parchem JG, Harris AD, Pineles BL. Delivery outcomes in a cohort of pregnant patients with COVID-19 with and without viral pneumonia. Am J Obstet Gynecol MFM. 2023 Oct;5(10):101077. doi: 10.1016/j.ajogmf.2023.101077. Epub 2023 Jul 1. PMID: 37399892; PMCID: PMC11018246.

Nadimpalli G, Johnson JK, Magder LS, Haririan A, Stevens D, Harris AD, O'Hara LM. Efficacy of a continuously active disinfectant wipe on the environmental bioburden in the intensive care unit: A randomized controlled study. Infect Control Hosp Epidemiol. 2023 Dec;44(12):2036-2043. doi: 10.1017/ice.2023.111. Epub 2023 Jul 3. PMID: 37395041.

Ebuka I. Onyenobi

Mentor: Sally Adebamowo, MBBS, MSc, ScD

Hou K, Gogarten S, Kim J, Hua X, Dias JA, Sun Q, Wang Y, Tan T; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group; Atkinson EG, Martin A, Shortt J, Hirbo J, Li Y, Pasaniuc B, Zhang H. Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations. Bioinformatics. 2024 Mar 29;40(4):btae148. doi: 10.1093/bioinformatics/btae148. PMID: 38490256; PMCID: PMC10980565.

Nandini Raghuraman

Mentor: Luana Colloca, MD, PhD

Raghuraman N, White JN, Watson L, Belleï-Rodriguez CÉ, Shafir R, Wang Y, Colloca L. Neuropsychological mechanisms of observational learning in human placebo effects. Psychopharmacology (Berl). 2024 May 14. doi: 10.1007/s00213-024-06608-7. Epub ahead of print. PMID: 38743108.

Sarah J. Robbins

Mentor: Rebecca M. Brotman, MPH, PhD

Stennett CA, France M, Shardell M, Robbins SJ, Brown SE, Johnston ED, Mark K, Ravel J, Brotman RM. Longitudinal profiles of the vaginal microbiota of pre-, peri-, and postmenopausal women: preliminary insights from a secondary data analysis. Menopause. 2024 Jun 1;31(6):537-545. doi: 10.1097/GME.0000000000002358. PMID: 38787353.

Robbins SJ, Brown SE, Stennett CA, Tuddenham S, Johnston ED, Wnorowski AM, Ravel J, He X, Mark KS, Brotman RM. Uterine fibroids and longitudinal profiles of the vaginal microbiota in a cohort presenting for transvaginal ultrasound. PLoS One. 2024 Feb 5;19(2):e0296346. doi: 10.1371/journal.pone.0296346. PMID: 38315688; PMCID: PMC10843103.

Richard D. Smith

Mentors: Robert K. Ernst, PhD and J. Kristie Johnson, PhD, D(ABMM)

Nemeth AM, Young MM, Melander RJ, Smith RD, Ernst RK, Melander C. Identification of a 2-Aminobenzimidazole Scaffold that Potentiates Gram-Positive Selective Antibiotics Against Gram-Negative Bacteria. Chembiochem. 2024 Apr 16;25(8):e202400127. doi: 10.1002/cbic.202400127. Epub 2024 Mar 27. PMID: 38451872; PMCID: PMC11021177.

Smith RD, Zhan M, Zhang S, Leekha S, Harris A, Doi Y, Evans S, Kristie Johnson J, Ernst RK. Comparison of three rapid diagnostic tests for bloodstream infections using Benefit-risk Evaluation Framework (BED-FRAME). J Clin Microbiol. 2024 Jan 17;62(1):e0109623. doi: 10.1128/jcm.01096-23. Epub 2023 Dec 6. PMID: 38054730; PMCID: PMC10793330.

Smith RD, Johnson JK, Ernst RK. Comparison of 3 diagnostic platforms for identification of bacteria and yeast from positive blood culture bottles. Diagn Microbiol Infect Dis. 2023 Oct;107(2):116018. doi: 10.1016/j.diagmicrobio.2023.116018. Epub 2023 Jul 7. PMID: 37478505.

Christina A. Stennett

Mentor: Rebecca M. Brotman, MPH, PhD

Stennett CA, France M, Shardell M, Robbins SJ, Brown SE, Johnston ED, Mark K, Ravel J, Brotman RM. Longitudinal profiles of the vaginal microbiota of pre-, peri-, and postmenopausal women: preliminary insights from a secondary data analysis. Menopause. 2024 Jun 1;31(6):537-545. doi: 10.1097/GME.0000000000002358. PMID: 38787353.

Robbins SJ, Brown SE, Stennett CA, Tuddenham S, Johnston ED, Wnorowski AM, Ravel J, He X, Mark KS, Brotman RM. Uterine fibroids and longitudinal profiles of the vaginal microbiota in a cohort presenting for transvaginal ultrasound. PLoS One. 2024 Feb 5;19(2):e0296346. doi: 10.1371/journal.pone.0296346. PMID: 38315688; PMCID: PMC10843103.

Emily M. Stucke

Mentor: Mark A. Travassos, MD, MSc

Tebben K, Yirampo S, Coulibaly D, Koné AK, Laurens MB, Stucke EM, Dembélé A, Tolo Y, Traoré K, Niangaly A, Berry AA, Kouriba B, Plowe CV, Doumbo OK, Lyke KE, Takala-Harrison S, Thera MA, Travassos MA, Serre D. Gene expression analyses reveal differences in children's response to malaria according to their age. Nat Commun. 2024 Mar 6;15(1):2021. doi: 10.1038/s41467-024-46416-3. PMID: 38448421; PMCID: PMC10918175.

Stucke EM, Lawton JG, Travassos MA. ApoE: A new piece to the severe malaria puzzle. Pediatr Res. 2024 Feb 22. doi: 10.1038/s41390-024-03096-5. Epub ahead of print. PMID: 38388820.

Tewey MA, Coulibaly D, Lawton JG, Stucke EM, Zhou AE, Berry AA, Bailey JA, Pike A, Dara A, Ouattara A, Lyke KE, Ifeonu O, Laurens MB, Adams M, Takala-Harrison S, Niangaly A, Kouriba B, Koné AK, Rowe JA, Doumbo OK, Patel JJ, Tan JC, Felgner PL, Plowe CV, Thera MA, Travassos MA. Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s. mSphere. 2023 Oct 24;8(5):e0045123. doi: 10.1128/msphere.00451-23. Epub 2023 Oct 4. PMID: 37791774; PMCID: PMC10597466.

Jimmy Vareta

Mentor: Miriam K. Laufer, MD

Vareta J, Horstman NA, Adams M, Seydel KB, McCann RS, Cohee LM, Laufer MK, Takala-Harrison S. Genotyping Plasmodium falciparum gametocytes using amplicon deep sequencing. Malar J. 2024 Apr 6;23(1):96. doi: 10.1186/s12936-024-04920-3. PMID: 38582837; PMCID: PMC10999092.

Diego Veliz-Otani

Mentor: Timothy D. O'Connor, PhD

Kim JJ, Vitale D, Otani DV, Lian MM, Heilbron K; 23andMe Research Team; Iwaki H, Lake J, Solsberg CW, Leonard H, Makarious MB, Tan EK, Singleton AB, Bandres-Ciga S, Noyce AJ; Global Parkinson’s Genetics Program (GP2); Blauwendraat C, Nalls MA, Foo JN, Mata I. Multi-ancestry genome-wide association meta-analysis of Parkinson's disease. Nat Genet. 2024 Jan;56(1):27-36. doi: 10.1038/s41588-023-01584-8. Epub 2023 Dec 28. PMID: 38155330; PMCID: PMC10786718.

Zhenyao Ye

Mentor: Shuo Chen, PhD

Lee H, Ma T, Ke H, Ye Z, Chen S. dCCA: detecting differential covariation patterns between two types of high-throughput omics data. Brief Bioinform. 2024 May 23;25(4):bbae288. doi: 10.1093/bib/bbae288. PMID: 38888456; PMCID: PMC11184902.

Pan Y, Bi C, Kochunov P, Shardell M, Smith JC, McCoy RG, Ye Z, Yu J, Lu T, Yang Y, Lee H, Liu S, Gao S, Ma Y, Li Y, Chen C, Ma T, Wang Z, Nichols T, Hong LE, Chen S. Brain-wide functional connectome analysis of 40,000 individuals reveals brain networks that show aging effects in older adults. bioRxiv [Preprint]. 2024 May 17:2024.05.17.594743. doi: 10.1101/2024.05.17.594743. PMID: 38798606; PMCID: PMC11118564.

Feng L, Ye Z, Du Z, Pan Y, Canida T, Ke H, Liu S, Chen S, Hong LE, Kochunov P, Chen J, Lei DKY, Shenassa E, Ma T. Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank. medRxiv [Preprint]. 2024 May 9:2024.01.26.24301793. doi: 10.1101/2024.01.26.24301793. PMID: 38343822; PMCID: PMC10854327.

Tian C, Ye Z, McCoy RG, Pan Y, Bi C, Gao S, Ma Y, Chen M, Yu J, Lu T, Hong LE, Kochunov P, Ma T, Chen S, Liu S. The causal effect of HbA1c on white matter brain aging by two-sample Mendelian randomization analysis. Front Neurosci. 2024 Jan 11;17:1335500. doi: 10.3389/fnins.2023.1335500. PMID: 38274506; PMCID: PMC10808780.

Ye Z, Pan Y, McCoy RG, Bi C, Chen M, Feng L, Yu J, Lu T, Liu S, Gao S, Hatch KS, Ma Y, Chen C, Mitchell BD, Thompson PM, Hong LE, Kochunov P, Ma T, Chen S. APOE4 poses opposite effects of plasma LDL on white matter integrity in older adults. bioRxiv [Preprint]. 2023 Oct 28:2023.10.24.563796. doi: 10.1101/2023.10.24.563796. PMID: 37961161; PMCID: PMC10634787.

Feng L, Ye Z, Mo C, Wang J, Liu S, Gao S, Ke H, Canida TA, Pan Y, Greevenbroek MMJV, Houben AJHM, Wang K, Hatch KS, Ma Y, Lei DKY, Chen C, Mitchell BD, Hong LE, Kochunov P, Chen S, Ma T. Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK Biobank. J Hypertens. 2023 Nov 1;41(11):1811-1820. doi: 10.1097/HJH.0000000000003553. Epub 2023 Sep 5. PMID: 37682053; PMCID: PMC11083214.

Mo C, Ye Z, Pan Y, Zhang Y, Wu Q, Bi C, Liu S, Mitchell B, Kochunov P, Hong LE, Ma T, Chen S. An in-depth association analysis of genetic variants within nicotine-related loci: Meeting in middle of GWAS and genetic fine-mapping. Mol Cell Neurosci. 2023 Dec;127:103895. doi: 10.1016/j.mcn.2023.103895. Epub 2023 Aug 25. PMID: 37634742; PMCID: PMC11128188.

Ye Z, Mo C, Liu S, Gao S, Feng L, Zhao B, Canida T, Wu YC, Hatch KS, Ma Y, Mitchell BD, Hong LE, Kochunov P, Chen C, Zhao B, Chen S, Ma T. Deciphering the causal relationship between blood pressure and regional white matter integrity: A two-sample Mendelian randomization study. J Neurosci Res. 2023 Sep;101(9):1471-1483. doi: 10.1002/jnr.25205. Epub 2023 Jun 18. PMID: 37330925; PMCID: PMC10444533.

Haichen Zhang

Mentor: Toni I. Pollin, PhD

Pavithram A, Zhang H, Maloney KA, Ringdal M, Kaci A, Sagen JV, Kleinberger J, Jeng LJB, Njølstad PR, Pollin TI, Molnes J, Johansson BB. In Vitro Functional Analysis Can Aid Precision Diagnostics of HNF1B-MODY. J Mol Diagn. 2024 Jun;26(6):530-541. doi: 10.1016/j.jmoldx.2024.03.006. Epub 2024 Apr 3. PMID: 38575066.

Albert E. Zhou

Mentor: Mark A. Travassos, MD, MSc

Tewey MA, Coulibaly D, Lawton JG, Stucke EM, Zhou AE, Berry AA, Bailey JA, Pike A, Dara A, Ouattara A, Lyke KE, Ifeonu O, Laurens MB, Adams M, Takala-Harrison S, Niangaly A, Kouriba B, Koné AK, Rowe JA, Doumbo OK, Patel JJ, Tan JC, Felgner PL, Plowe CV, Thera MA, Travassos MA. Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s. mSphere. 2023 Oct 24;8(5):e0045123. doi: 10.1128/msphere.00451-23. Epub 2023 Oct 4. PMID: 37791774; PMCID: PMC10597466.

Ranyah Almardawi

Mentor: To Be Determined

Almardawi R, Garcia Zapata L, Gill R, Addona J, Kapustina I, Ahmed SR, Kani K, Davis DL. Single slice MR image estimation of 3D supraspinatus intramuscular fatty infiltration in older adults: relevance for clinical practice and research. Skeletal Radiol. 2024 May 23. doi: 10.1007/s00256-024-04706-3. Epub ahead of print. PMID: 38782772.

Davis DL, Almardawi R, Beamer BA, Ryan AS, Terrin ML. Shoulder pain, health-related quality of life and physical function in community-dwelling older adults. Front Aging. 2023 Jul 6;4:1176706. doi: 10.3389/fragi.2023.1176706. PMID: 37483647; PMCID: PMC10359925.

Rashmita Bajracharya

Mentor: Denise L. Orwig, PhD

Prasad NK, Bajracharya R, Wijesinha M, Rathbun A, Orwig D, Magder L, Gruber-Baldini A, Mangione K, Craik RL, Magaziner J. Multicomponent Home-based Physical Therapy Versus Usual Care for Recovery After Hip Fracture. Arch Phys Med Rehabil. 2023 Dec;104(12):2011-2018. doi: 10.1016/j.apmr.2023.05.001. Epub 2023 Aug 22. PMID: 37610404; PMCID: PMC10840126.

Bajracharya R, Guralnik JM, Shardell MD, Hochberg MC, Orwig DL, Magaziner JS. Predictors of mobility status one year post hip fracture among community-dwelling older adults prior to fracture: A prospective cohort study. J Am Geriatr Soc. 2023 Aug;71(8):2441-2450. doi: 10.1111/jgs.18327. Epub 2023 Mar 14. PMID: 36918363; PMCID: PMC10440300.

Haesung (Evelyn) Kim

Mentor: Ann L. Gruber-Baldini

Kim H, Shulman LM, Shakya S, Gruber-Baldini A. The effects of medical comorbidity, cognition, and age on patient-reported outcomes in Parkinson's disease. Parkinsonism Relat Disord. 2023 Nov;116:105892. doi: 10.1016/j.parkreldis.2023.105892. Epub 2023 Oct 10. PMID: 37837675; PMCID: PMC10841750.

Jennifer Kirk

Mentors: Jennifer S. Albrecht, Alan M. Rathbun, Denise L. Orwig

Kirk J, Wickwire EM, Somers VK, Johnson DA, Albrecht JS. Undiagnosed obstructive sleep apnea increases risk of hospitalization among a racially diverse group of older adults with comorbid cardiovascular disease. J Clin Sleep Med. 2023 Jul 1;19(7):1175-1181. doi: 10.5664/jcsm.10526. PMID: 36803353; PMCID: PMC10315599.

Rachel McPherson

Mentor: Barbara M. Resnick, PhD

Resnick B, Boltz M, Galik E, Kuzmik A, McPherson R, Drazich B, Kim N, Zhu S, Wells CL. Measurement of Physical Activity Among Hospitalized Older Adults Living With Dementia. Rehabil Nurs. 2024 Jul-Aug 01;49(4):115-124. doi: 10.1097/RNJ.0000000000000464. Epub 2024 Jun 20. PMID: 38904657; PMCID: PMC11222057.

McPherson R, Resnick B, Boltz M, Kuzmik A, Galik E, Kim N, Zhu S. The association between patient engagement and quality of care interactions among acute care patients with dementia. Geriatr Nurs. 2024 May-Jun;57:117-122. doi: 10.1016/j.gerinurse.2024.04.002. Epub 2024 Apr 18. PMID: 38640645; PMCID: PMC11144554.

Kuzmik A, Boltz M, Resnick B, McPherson R, Rodriguez M, Drazich BF, Galik E. Delirium Severity and Physical Function in Hospitalized Persons Living With Dementia: Moderation by Age, Sex, and Race. Alzheimer Dis Assoc Disord. 2024 Jan-Mar 01;38(1):28-33. doi: 10.1097/WAD.0000000000000601. Epub 2024 Jan 22. PMID: 38277635; PMCID: PMC10922871.

Resnick B, McPherson R, Galik E. Pilot testing implementation of the pain management clinical practice guideline in nursing homes. Geriatr Nurs. 2024 Mar-Apr;56:18-24. doi: 10.1016/j.gerinurse.2023.12.012. Epub 2024 Jan 5. PMID: 38183965; PMCID: PMC11110890.

Wells CL, Resnick B, McPherson R, Frampton K. Implementation of the UMove Mobility Program to Promote Safe Patient Mobility and Reduce Falls in the Hospital Setting. Res Gerontol Nurs. 2024 Jan-Feb;17(1):19-29. doi: 10.3928/19404921-20231013-01. Epub 2023 Oct 20. PMID: 37878599.

Resnick B, Boltz M, Wells CL, Galik E, Kuzmik A, McPherson R. A Descriptive Study Using Rasch Analysis and Hypothesis Testing to Evaluate the Psychometric Properties of the UMOVE Mobility Screen Tested With Hospitalized Older Adults. J Aging Phys Act. 2023 Sep 23;32(1):83-90. doi: 10.1123/japa.2023-0017. PMID: 37741635; PMCID: PMC10841049.

Resnick B, Boltz M, Galik E, Kuzmik A, McPherson R, Drazich B, Kim N, Zhu S, Wells CL. Differences in Medication Use by Gender and Race in Hospitalized Persons Living with Dementia. J Racial Ethn Health Disparities. 2023 Aug 14:10.1007/s40615-023-01745-9. doi: 10.1007/s40615-023-01745-9. Epub ahead of print. PMID: 37580439; PMCID: PMC10864680.

Drazich BF, McPherson R, Gorman EF, Chan T, Teleb J, Galik E, Resnick B. In too deep? A systematic literature review of fully-immersive virtual reality and cybersickness among older adults. J Am Geriatr Soc. 2023 Dec;71(12):3906-3915. doi: 10.1111/jgs.18553. Epub 2023 Aug 10. PMID: 37560978.

McPherson R, Galik E, Gruber-Baldini AL, Holmes S, Kusmaul N, Resnick B. Model Testing of the Factors that are Associated with Care Interactions among Nursing Home Residents with Dementia. J Am Med Dir Assoc. 2023 Sep;24(9):1389-1395. doi: 10.1016/j.jamda.2023.06.014. Epub 2023 Jul 25. PMID: 37507101.

Resnick B, Boltz M, Galik E, Kuzmik A, Drazich BF, McPherson R, Wells CL. Factors Associated With Function-Focused Care Among Hospitalized Older Adults With Dementia. Am J Crit Care. 2023 Jul 1;32(4):264-274. doi: 10.4037/ajcc2023440. PMID: 37391379.

McPherson R, Resnick B, Wallace BH. Differences in Staff-Resident Care Interactions by Nursing Home Racial Composition: a Preliminary Analysis. J Racial Ethn Health Disparities. 2024 Aug;11(4):2055-2063. doi: 10.1007/s40615-023-01673-8. Epub 2023 Jun 14. PMID: 37314689.

Rhea Mehta

Mentor: Alan M. Rathbun, PhD

Rathbun AM, Shardell MD, Gallo JJ, Ryan AS, Stuart EA, Schuler MS, Dong Y, Beamer B, Mehta R, Peer JE, Hochberg MC. Time-varying treatment effect modification of oral analgesic effectiveness by depressive symptoms in knee osteoarthritis: an application of structural nested mean models in a prospective cohort. Int J Epidemiol. 2024 Feb 1;53(1):dyad152. doi: 10.1093/ije/dyad152. PMID: 37934603.

Mehta R, Hochberg M, Shardell M, Ryan A, Dong Y, Beamer BA, Peer J, Stuart EA, Schuler M, Gallo JJ, Rathbun AM. Evaluation of Dynamic Effects of Depressive Symptoms on Physical Function in Knee Osteoarthritis. Arthritis Care Res (Hoboken). 2024 May;76(5):673-681. doi: 10.1002/acr.25295. Epub 2024 Jan 31. PMID: 38200641; PMCID: PMC11039384.

Rathbun AM, Mehta R, Ryan AS, Dong Y, Beamer B, Golden J, Gallo JJ, Luborsky M, Shardell MD, Peer JE, Hochberg MC. Duloxetine plus exercise for knee osteoarthritis and depression: A feasibility study. Osteoarthr Cartil Open. 2023 Dec 8;6(1):100426. doi: 10.1016/j.ocarto.2023.100426. PMID: 38130375; PMCID: PMC10733673.

Heather Mutchie

Mentor: Ann L. Gruber-Baldini, PhD

Mutchie HL, Orwig DL, Gruber-Baldini AL, Johnson A, Magaziner J, Falvey JR. Associations of sex, Alzheimer's disease and related dementias, and days alive and at home among older Medicare beneficiaries recovering from hip fracture. J Am Geriatr Soc. 2023 Oct;71(10):3134-3142. doi: 10.1111/jgs.18492. Epub 2023 Jul 4. PMID: 37401789; PMCID: PMC11087867.

Shalini Sahoo

Mentor: John D. Sorkin, MD, PhD

Vemuri C, Gibson KD, Pappas PJ, Sadek M, Ting W, Obi AT, Mouawad NJ, Etkin Y, Gasparis AP, McDonald T, Sahoo S, Sorkin JD, Lal BK. Effect of junctional reflux on the venous clinical severity score in patients with insufficiency of the great saphenous vein (JURY study). J Vasc Surg Venous Lymphat Disord. 2024 Mar;12(2):101700. doi: 10.1016/j.jvsv.2023.101700. Epub 2023 Nov 11. PMID: 37956904; PMCID: PMC10939725.

Hayssen H, Sahoo S, Nguyen P, Mayorga-Carlin M, Siddiqui T, Englum B, Slejko JF, Mullins CD, Yesha Y, Sorkin JD, Lal BK. Ability of Caprini and Padua risk-assessment models to predict venous thromboembolism in a nationwide Veterans Affairs study. J Vasc Surg Venous Lymphat Disord. 2024 Mar;12(2):101693. doi: 10.1016/j.jvsv.2023.101693. Epub 2023 Oct 12. PMID: 37838307; PMCID: PMC10922503.

Englum BR, Sahoo S, Mayorga-Carlin M, Hayssen H, Siddiqui T, Turner DJ, Sorkin JD, Lal BK. Growing Deficit in New Cancer Diagnoses 2 Years Into the COVID-19 Pandemic: A National Multicenter Study. Ann Surg Oncol. 2023 Dec;30(13):8509-8518. doi: 10.1245/s10434-023-14217-5. Epub 2023 Sep 11. PMID: 37695458; PMCID: PMC10939008.

Sahoo S, Hayssen H, Englum B, Mayorga-Carlin M, Siddiqui T, Nguyen P, Kankaria A, Yesha Y, Sorkin JD, Lal BK. Prediction of bleeding in patients being considered for venous thromboembolism prophylaxis. J Vasc Surg Venous Lymphat Disord. 2023 Nov;11(6):1182-1191.e13. doi: 10.1016/j.jvsv.2023.07.007. Epub 2023 Jul 25. PMID: 37499868; PMCID: PMC11017967.

Madeline Alizadeh

Mentor: Jacques Ravel, PhD

Gil A, Alizadeh M, Yarmovsky D, Swamy R, Wong U. Use of Systemic Steroids for Inflammatory Bowel Disease Can Increase Intraocular Pressure. Gastro Hep Adv. 2024;3(4):536-538. doi: 10.1016/j.gastha.2024.01.008. Epub 2024 Jan 23. PMID: 38912386; PMCID: PMC11192506.

Alizadeh M, Wong U, Siaton BC, Patil SA, George L, Raufman JP, Scott WH, von Rosenvinge EC, Ravel J, Cross RK. Inflammatory Bowel Disease-Associated Arthritis Is Associated with Concomitant Autoimmune and Inflammatory Disorders. Dig Dis Sci. 2024 Jun 20. doi: 10.1007/s10620-024-08478-7. Epub ahead of print. PMID: 38902460.

Motwani KK, Alizadeh M, Abutaleb A, Grossman J, Wellington J, Cross RK; SPARC-IBD investigators. Correction to: Correlation Between Plasma and Fecal Biomarkers and Patient‑Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis. Dig Dis Sci. 2024 Jun;69(6):2164. doi: 10.1007/s10620-024-08469-8. Erratum for: Dig Dis Sci. 2024 Jun;69(6):2154-2163. doi: 10.1007/s10620-024-08421-w. PMID: 38753242.

Motwani KK, Alizadeh M, Abutaleb A, Grossman J, Wellington J, Cross RK; SPARC-IBD investigators. Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis. Dig Dis Sci. 2024 Jun;69(6):2154-2163. doi: 10.1007/s10620-024-08421-w. Epub 2024 Apr 5. Erratum in: Dig Dis Sci. 2024 Jun;69(6):2164. doi: 10.1007/s10620-024-08469-8. PMID: 38580888.

Alizadeh M, Ali O, Cross RK. Assessing Progression of Biologic Therapies Based on Smoking Status in Patients With Crohn's Disease. Inflamm Bowel Dis. 2024 May 2;30(5):788-794. doi: 10.1093/ibd/izad131. PMID: 37478408; PMCID: PMC11063538.

Sampaio Moura N, Schledwitz A, Alizadeh M, Kodan A, Njei LP, Raufman JP. Cholinergic Mechanisms in Gastrointestinal Neoplasia. Int J Mol Sci. 2024 May 13;25(10):5316. doi: 10.3390/ijms25105316. PMID: 38791353; PMCID: PMC11120676.

Ali O, Kesar V, Alizadeh M, Kalachi K, Twery B, Wellnitz N, Kim RE, Goldberg E, Uradomo LT, Darwin PE. Low-dose pulsed vs standard pulsed fluoroscopy during ERCP to reduce radiation without change in image quality: Prospective randomized study. Endosc Int Open. 2024 Apr 15;12(4):E554-E560. doi: 10.1055/a-2284-8656. PMID: 38628393; PMCID: PMC11018389.

Alizadeh M, Wong U, Siaton BC, Patil SA, George L, Raufman JP, Scott WH, von Rosenvinge EC, Ravel J, Cross RK. ExpLOring the role of the intestinal MiCrobiome in InflammATory bowel disease-AssocIated SpONdylarthritis (LOCATION-IBD). Heliyon. 2024 Feb 18;10(4):e26571. doi: 10.1016/j.heliyon.2024.e26571. PMID: 38420375; PMCID: PMC10900801.

Sampaio Moura N, Schledwitz A, Alizadeh M, Patil SA, Raufman JP. Matrix metalloproteinases as biomarkers and therapeutic targets in colitis-associated cancer. Front Oncol. 2024 Jan 15;13:1325095. doi: 10.3389/fonc.2023.1325095. PMID: 38288108; PMCID: PMC10824561.

Alizadeh M, Motwani K, Siaton BC, Abutaleb A, Ravel J, Cross RK; SPARC-IBD Investigators. Factors Associated With Extraintestinal Manifestations of Inflammatory Bowel Disease in SPARC-IBD. Inflamm Bowel Dis. 2023 Dec 15:izad280. doi: 10.1093/ibd/izad280. Epub ahead of print. PMID: 38102817.

Alizadeh M, Sampaio Moura N, Schledwitz A, Patil SA, El-Serag H, Ravel J, Raufman JP. A Practical Guide to Evaluating and Using Big Data in Digestive Disease Research. Gastroenterology. 2024 Feb;166(2):240-247. doi: 10.1053/j.gastro.2023.11.292. Epub 2023 Dec 3. PMID: 38052336; PMCID: PMC10872385.

Alizadeh M, Sampaio Moura N, Schledwitz A, Patil SA, Ravel J, Raufman JP. Gastroenterology Fellowship and Postdoctoral Training in Omics and Statistics-Part II: How Can It Be Achieved? Dig Dis Sci. 2024 Jan;69(1):22-26. doi: 10.1007/s10620-023-08149-z. Epub 2023 Nov 2. PMID: 37919515; PMCID: PMC10876148.

Alizadeh M, Sampaio Moura N, Schledwitz A, Patil SA, Ravel J, Raufman JP. Gastroenterology Fellowship and Postdoctoral Training in Omics and Statistics-Part I: Why Is It Needed? Dig Dis Sci. 2024 Jan;69(1):18-21. doi: 10.1007/s10620-023-08136-4. Epub 2023 Nov 2. PMID: 37919514; PMCID: PMC10878129.

Alizadeh M, Ali O, Cross RK. Extraintestinal Manifestations of Inflammatory Bowel Disease Are Associated With Increased Biologic Cycling. Crohns Colitis 360. 2023 Oct 4;5(4):otad058. doi: 10.1093/crocol/otad058. PMID: 37901191; PMCID: PMC10601919.

George LA, Feldman HT, Alizadeh M, Abutaleb A, Zullow S, Hine A, Stashek K, Sarkar S, Sun K, Hudesman D, Axelrad J, Cross RK. Histologic Inflammation can Predict Future Clinical Relapse in Ulcerative Colitis Patients in Endoscopic Remission. Crohns Colitis 360. 2023 Oct 18;5(4):otad059. doi: 10.1093/crocol/otad059. PMID: 37886705; PMCID: PMC10599395.

Cheng K, Chahdi A, Larabee SM, Tolaymat M, Sundel MH, Drachenberg CB, Zhan M, Hu S, Said AH, Shang AC, Xie G, Alizadeh M, Moura NS, Bafford AC, Williams RT, Hanna NN, Raufman JP. Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia. Sci Rep. 2023 Oct 7;13(1):16920. doi: 10.1038/s41598-023-44158-8. PMID: 37805544; PMCID: PMC10560271.

Haikel N. Bogale

Mentor: David Serre, Dr.rer.nat

Rolandelli A, Laukaitis-Yousey HJ, Bogale HN, Singh N, Samaddar S, O'Neal AJ, Ferraz CR, Butnaru M, Mameli E, Xia B, Mendes MT, Butler LR, Marnin L, Cabrera Paz FE, Valencia LM, Rana VS, Skerry C, Pal U, Mohr SE, Perrimon N, Serre D, Pedra JHF. Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness. Nat Commun. 2024 Mar 8;15(1):2117. doi: 10.1038/s41467-024-46494-3. PMID: 38459063; PMCID: PMC10923820.

Hazzard B, Sá JM, Bogale HN, Pascini TV, Ellis AC, Amin S, Armistead JS, Adams JH, Wellems TE, Serre D. Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission. Res Sq [Preprint]. 2024 Feb 13:rs.3.rs-3888175. doi: 10.21203/rs.3.rs-3888175/v1. PMID: 38410426; PMCID: PMC10896380.

Marnin L, Bogale HN, Laukaitis-Yousey HJ, Valencia LM, Rolandelli A, O'Neal AJ, Ferraz CR, Schmitter-Sánchez AD, Cuevas EB, Nguyen TT, Leal-Galvan B, Rickert DM, Bruno VM, Tays Mendes M, Samaddar S, Rainer Butler L, Singh N, Cabrera Paz FE, Oliver JD, Jameson JM, Munderloh UG, Oliva Chávez AS, Mulenga A, Park S, Serre D, Pedra JHF. Tick extracellular vesicles impair epidermal homeostasis through immune-epithelial networks during hematophagy. bioRxiv [Preprint]. 2023 Nov 10:2023.11.10.566612. doi: 10.1101/2023.11.10.566612. PMID: 37986907; PMCID: PMC10659423.

Robert A. Brown

Mentor: Michal Zalzman, PhD

Meltzer WA, Gupta A, Lin PN, Brown RA, Benyamien-Roufaeil DS, Khatri R, Mahurkar AA, Song Y, Taylor RJ, Zalzman M. Reprogramming Chromosome Ends by Functional Histone Acetylation. Int J Mol Sci. 2024 Mar 31;25(7):3898. doi: 10.3390/ijms25073898. PMID: 38612707; PMCID: PMC11011970.

Kumar A, Brown RA, Roufaeil DB, Gupta A, Lipford EL, Muthusamy D, Zalzman A, Hertzano R, Lowe T, Stains JP, Zalzman M. DeepFreeze 3D-biofabrication for Bioengineering and Storage of Stem Cells in Thick and Large-Scale Human Tissue Analogs. Adv Sci (Weinh). 2024 Mar;11(11):e2306683. doi: 10.1002/advs.202306683. Epub 2024 Jan 6. PMID: 38183347; PMCID: PMC10953591.

Heather V. Buck

Mentor: Joseph P. Stains, PhD

Buck HV, Torre OM, Leser JM, Gould NR, Ward CW, Stains JP. Nitric oxide contributes to rapid sclerostin protein loss following mechanical load. Biochem Biophys Res Commun. 2024 Jun 27;727:150315. doi: 10.1016/j.bbrc.2024.150315. Epub ahead of print. PMID: 38950493.

Buck HV, Stains JP. Osteocyte-mediated mechanical response controls osteoblast differentiation and function. Front Physiol. 2024 Mar 11;15:1364694. doi: 10.3389/fphys.2024.1364694. PMID: 38529481; PMCID: PMC10961341.

Leser JM, Torre OM, Gould NR, Guo Q, Buck HV, Kodama J, Otsuru S, Stains JP. Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2304492120. doi: 10.1073/pnas.2304492120. Epub 2023 Nov 17. PMID: 37976259; PMCID: PMC10666124.

Christine P. Carney

Mentor: Jeffrey A. Winkles, PhD

Carney CP, Pandey N, Kapur A, Saadi H, Ong HL, Chen C, Winkles JA, Woodworth GF, Kim AJ. Impact of Targeting Moiety Type and Protein Corona Formation on the Uptake of Fn14-Targeted Nanoparticles by Cancer Cells. ACS Nano. 2023 Oct 24;17(20):19667-19684. doi: 10.1021/acsnano.3c02575. Epub 2023 Oct 9. PMID: 37812740.

Alex Casella

Mentor: Seth A. Ament, PhD

Sonthalia S, Li G, Blanco XM, Casella A, Liu J, Stein-O'Brien G, Caffo B, Adkins RS, Orvis J, Hertzano R, Mahurkar A, Gillis J, Werner J, Ma S, Micali N, Sestan N, Rakic P, Santpere G, Ament SA, Colantuoni C. in silico transcriptome dissection of neocortical excitatory neurogenesis via joint matrix decomposition and transfer learning. bioRxiv [Preprint]. 2024 Feb 28:2024.02.26.581612. doi: 10.1101/2024.02.26.581612. PMID: 38464021; PMCID: PMC10925183.

Katarina T. Chang

Mentor: Stuart S. Martin, PhD

Mull ML, Pratt SJP, Thompson KN, Annis DA, Gad AA, Lee RM, Chang KT, Stemberger MB, Ju JA, Gilchrist DE, Boyman L, Vitolo MI, Lederer WJ, Martin SS. Disruption of P2Y2 signaling promotes breast tumor cell dissemination by reducing ATP-dependent calcium elevation and actin localization to cell junctions. bioRxiv [Preprint]. 2024 Jun 13:2023.03.31.533191. doi: 10.1101/2023.03.31.533191. PMID: 37034765; PMCID: PMC10081304.

Gillian M. Choquette

Mentor: Ryan C. Riddle, PhD

Riddle RC, Choquette GM. Serine synthesis promotes bone degradation. Nat Metab. 2024 Jan;6(1):8-9. doi: 10.1038/s42255-023-00949-x. PMID: 38200113.

Andrew K. Coleman

Mentor: W. Jonathan Lederer, MD, PhD

Vanegas C, Ursitti J, Kallenbach JG, Pinto K, Harriot A, Coleman AK, Shi G, Ward CW. Acute microtubule changes linked to DMD pathology are insufficient to impair contractile function or enhance contraction-induced injury in healthy muscle. bioRxiv [Preprint]. 2024 Jun 23:2024.06.19.599775. doi: 10.1101/2024.06.19.599775. PMID: 38948772; PMCID: PMC11212994.

Karbowski M, Boyman L, Garber L, Joca HC, Verhoeven N, Coleman AK, Ward CW, Lederer WJ, Greiser M. Na + /K + ATPase-Ca v 1.2 nanodomain differentially regulates intracellular [Na + ], [Ca 2+ ] and local adrenergic signaling in cardiac myocytes. bioRxiv [Preprint]. 2023 Sep 2:2023.08.31.553598. doi: 10.1101/2023.08.31.553598. PMID: 37693446; PMCID: PMC10491240.

Adonis D'Mello

Mentor: Herve Tettelin, PhD

Alles M, Gunasena M, Zia T, D'Mello A, Bhattarai S, Mulhern W, Terry L, Scherger T, Wijeratne S, Singh S, Wijeratne AJ, Kasturiratna D, Tettelin H, Weyand NJ, Liyanage NPM. Unveiling the immune dynamics of Neisseria persistent oral colonization. Infect Immun. 2024 Jul 11;92(7):e0004824. doi: 10.1128/iai.00048-24. Epub 2024 May 30. PMID: 38814083; PMCID: PMC11238562.

Salerno-Goncalves R, Chen H, Bafford AC, Izquierdo M, Hormazábal JC, Lagos R, Tettelin H, D'Mello A, Booth JS, Fasano A, Levine MM, Sztein MB. Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis. Front Immunol. 2024 Mar 12;15:1334762. doi: 10.3389/fimmu.2024.1334762. PMID: 38533492; PMCID: PMC10963533.

Salerno-Goncalves R, Chen H, Bafford AC, Izquierdo M, Hormazábal JC, Lagos R, Tettelin H, D'Mello A, Booth JS, Fasano A, Levine MM, Sztein MB. Early host immune responses in a human organoid-derived gallbladder monolayer to Salmonella Typhi strains from patients with acute and chronic infections: a comparative analysis. Front Immunol. 2024 Mar 12;15:1334762. doi: 10.3389/fimmu.2024.1334762. PMID: 38533492; PMCID: PMC10963533.

Dipanwita Dutta Chowdhury

Mentor: Phuoc T. Tran, MD, PhD

Nguyen T, Carrieri FA, Connis N, Lafargue A, Chang J, Chan A, Shetty AC, Song Y, Hoang T, Jagtap S, Chowdhury DD, Khan MA, Gabrielson KL, Rezaee M, Torres-Ayuso P, Brognard J, Hann CL, Tran PT. TNIK inhibition sensitizes TNIK-overexpressing lung squamous cell carcinoma to radiotherapy. Mol Cancer Ther. 2024 Apr 27. doi: 10.1158/1535-7163.MCT-23-0412. Epub ahead of print. PMID: 38670554.

Daniela T. Fuller

Mentors: Ruya Liu, BM, PhD and Christopher W. Ward, PhD

Kawai K, Sakamoto A, Mokry M, Ghosh SKB, Kawakami R, Xu W, Guo L, Fuller DT, Tanaka T, Shah P, Cornelissen A, Sato Y, Mori M, Konishi T, Vozenilek AE, Dhingra R, Virmani R, Pasterkamp G, Finn AV. Clonal Proliferation Within Smooth Muscle Cells in Unstable Human Atherosclerotic Lesions. Arterioscler Thromb Vasc Biol. 2023 Dec;43(12):2333-2347. doi: 10.1161/ATVBAHA.123.319479. Epub 2023 Oct 26. PMID: 37881937.

Abanoub A. Gad

Mentors: Narimen Balenga, PhD and Stuart S. Martin, PhD

Mull ML, Pratt SJP, Thompson KN, Annis DA, Gad AA, Lee RM, Chang KT, Stemberger MB, Ju JA, Gilchrist DE, Boyman L, Vitolo MI, Lederer WJ, Martin SS. Disruption of P2Y2 signaling promotes breast tumor cell dissemination by reducing ATP-dependent calcium elevation and actin localization to cell junctions. bioRxiv [Preprint]. 2024 Jun 13:2023.03.31.533191. doi: 10.1101/2023.03.31.533191. PMID: 37034765; PMCID: PMC10081304.

Nicole R. Gould

Mentor: Joseph P. Stains, PhD

Buck HV, Torre OM, Leser JM, Gould NR, Ward CW, Stains JP. Nitric oxide contributes to rapid sclerostin protein loss following mechanical load. Biochem Biophys Res Commun. 2024 Jun 27;727:150315. doi: 10.1016/j.bbrc.2024.150315. Epub ahead of print. PMID: 38950493.

Leser JM, Torre OM, Gould NR, Guo Q, Buck HV, Kodama J, Otsuru S, Stains JP. Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2304492120. doi: 10.1073/pnas.2304492120. Epub 2023 Nov 17. PMID: 37976259; PMCID: PMC10666124.

Kanwal Mahmood Hameed

Mentor: Ashkan Emadi, MD, PhD

Bollino D, Hameed K, Bhat A, Zarrabi A, Casildo A, Ma X, Tighe KM, Carter-Cooper B, Strovel ET, Lapidus RG, Emadi A. Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma. Cancer Metab. 2024 Jun 30;12(1):19. doi: 10.1186/s40170-024-00346-2. PMID: 38951899; PMCID: PMC11218198.

Hameed KM, Bollino DR, Shetty AC, Carter-Cooper B, Lapidus RG, Emadi A. Dual targeting of glutamine and serine metabolism in acute myeloid leukemia. Front Oncol. 2024 Apr 16;14:1326754. doi: 10.3389/fonc.2024.1326754. PMID: 38690164; PMCID: PMC11059989.

Brittany Hazzard

Mentor: David Serre, Dr. rer. nat.

Hazzard B, Sá JM, Bogale HN, Pascini TV, Ellis AC, Amin S, Armistead JS, Adams JH, Wellems TE, Serre D. Single-cell analyses of polyclonal Plasmodium vivax infections and their consequences on parasite transmission. Res Sq [Preprint]. 2024 Feb 13:rs.3.rs-3888175. doi: 10.21203/rs.3.rs-3888175/v1. PMID: 38410426; PMCID: PMC10896380.

Kevin Herold

Mentor: Ivy Dick, PhD

Herold K, Ruffin A, Chmura JC, Dellomo AJ, Ehrlich ES. Kaposi's sarcoma herpesvirus viral FLICE inhibitory protein modulates A20 deubiquitinase activity. Access Microbiol. 2024 May 9;6(5):000625.v4. doi: 10.1099/acmi.0.000625.v4. PMID: 38868372; PMCID: PMC11165616.

Christopher I. Holt

Mentor: Julie C. Dunning Hotopp, PhD

Mattick JSA, Bromley RE, Watson KJ, Adkins RS, Holt CI, Lebov JF, Sparklin BC, Tyson TS, Rasko DA, Hotopp JCD. Deciphering Bacterial and Archaeal Transcriptional Dark Matter and Its Architectural Complexity. bioRxiv [Preprint]. 2024 Apr 2:2024.04.02.587803. doi: 10.1101/2024.04.02.587803. PMID: 38617363; PMCID: PMC11014543.

Tierra A. Johnson

Mentor: Toni M. Antalis, PhD

Chernysh IN, Mukhopadhyay S, Johnson TA, Brooks JA, Sarkar R, Weisel JW, Antalis TM. Time-dependent ultrastructural changes during venous thrombogenesis and thrombus resolution. J Thromb Haemost. 2024 Jun;22(6):1675-1688. doi: 10.1016/j.jtha.2024.02.020. Epub 2024 Mar 15. PMID: 38492853; PMCID: PMC11139557.

Gurmannat Kalra

Mentor: Seth A. Ament, PhD

Kalra G, Lenz D, Abdul-Aziz D, Hanna C, Basu M, Herb BR, Colantuoni C, Milon B, Saxena M, Shetty AC, Hertzano R, Shivdasani RA, Ament SA, Edge ASB. Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells. Cell Rep. 2023 Nov 28;42(11):113421. doi: 10.1016/j.celrep.2023.113421. Epub 2023 Nov 11. PMID: 37952154; PMCID: PMC11007545.

Jeffrey A. Koenig

Mentor: Asaf Keller, PhD

Smith JA, Ji Y, Lorsung R, Breault MS, Koenig J, Cramer N, Masri R, Keller A. Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice. J Neurosci. 2023 Aug 2;43(31):5656-5667. doi: 10.1523/JNEUROSCI.0587-23.2023. Epub 2023 Jul 14. PMID: 37451980; PMCID: PMC10401640.

Jonelle K. Lee

Mentor: Maria R. Baer, MD

Lee JK, Chatterjee A, Scarpa M, Bailey CM, Niyongere S, Singh P, Mustafa Ali MK, Kapoor S, Wang Y, Silvestri G, Baer MR. Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3β Activation and c-Myc and Mcl-1 Proteasomal Degradation. Cancer Res Commun. 2024 Feb 16;4(2):431-445. doi: 10.1158/2767-9764.CRC-23-0379. PMID: 38284896; PMCID: PMC10870818.

Jenna M. Leser

Mentor: Joseph P. Stains, PhD

Buck HV, Torre OM, Leser JM, Gould NR, Ward CW, Stains JP. Nitric oxide contributes to rapid sclerostin protein loss following mechanical load. Biochem Biophys Res Commun. 2024 Jun 27;727:150315. doi: 10.1016/j.bbrc.2024.150315. Epub ahead of print. PMID: 38950493.

Leser JM, Torre OM, Gould NR, Guo Q, Buck HV, Kodama J, Otsuru S, Stains JP. Osteoblast-lineage calcium/calmodulin-dependent kinase 2 delta and gamma regulates bone mass and quality. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2304492120. doi: 10.1073/pnas.2304492120. Epub 2023 Nov 17. PMID: 37976259; PMCID: PMC10666124.

Oleg Makarevich

Mentor: Bogdan A. Stoica, MD

Henry RJ, Barrett JP, Vaida M, Khan NZ, Makarevich O, Ritzel RM, Faden AI, Stoica BA. Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction. J Neuroinflammation. 2024 Apr 29;21(1):113. doi: 10.1186/s12974-024-03107-6. PMID: 38685031; PMCID: PMC11058055.

Allison E. Mancini

Mentor: Megan A. Rizzo, PhD

Mancini AE, Rizzo MA. A novel single-color FRET biosensor for Rho-kinase activity reveals calcium-dependent activation of RhoA and ROCK. bioRxiv [Preprint]. 2024 May 31:2024.05.30.596680. doi: 10.1101/2024.05.30.596680. PMID: 38854028; PMCID: PMC11160749.

Adarsha Malla

Mentor: Graeme F. Woodworth, MD

Malla A, Hassan B, Er S, Liang F, Ptak T, Manson PN, Grant MP. Traumatic Brain Injury and Its Association With Orbital Fracture Characteristics and Repair. J Craniofac Surg. 2024 Jun 28. doi: 10.1097/SCS.0000000000010456. Epub ahead of print. PMID: 38940595.

Seas AA, Malla AP, Sharifai N, Winkles JA, Woodworth GF, Anastasiadis P. Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas. Biomedicines. 2024 Jun 1;12(6):1230. doi: 10.3390/biomedicines12061230. PMID: 38927437; PMCID: PMC11200892.

Paige McKeon

Mentor: Brian N. Mathur, PhD

Robertson CD, Davis P, Richardson RR, Iffland PH 2nd, Vieira DCO, Steyert M, McKeon PN, Romanowski AJ, Crutcher G, Jašarević E, Wolff SBE, Mathur BN, Crino PB, Bale TL, Dick IE, Poulopoulos A. Rapid modeling of an ultra-rare epilepsy variant in wild-type mice by in utero prime editing. bioRxiv [Preprint]. 2023 Dec 19:2023.12.06.570164. doi: 10.1101/2023.12.06.570164. PMID: 38106154; PMCID: PMC10723435.

Ian W. Mills

Mentor: Daria A. Gaykalova, PhD

Williams CH, Neitzel LR, Cornell J, Rea S, Mills I, Silver MS, Ahmad JD, Birukov KG, Birukova A, Brem H, Tyler B, Bar EE, Hong CC. GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. Exp Hematol Oncol. 2024 Jan 31;13(1):13. doi: 10.1186/s40164-023-00468-1. PMID: 38291540; PMCID: PMC10829393.

Makenzy L. Mull

Mentor: Stuart S. Martin, PhD

Mull ML, Pratt SJP, Thompson KN, Annis DA, Gad AA, Lee RM, Chang KT, Stemberger MB, Ju JA, Gilchrist DE, Boyman L, Vitolo MI, Lederer WJ, Martin SS. Disruption of P2Y2 signaling promotes breast tumor cell dissemination by reducing ATP-dependent calcium elevation and actin localization to cell junctions. bioRxiv [Preprint]. 2024 Jun 13:2023.03.31.533191. doi: 10.1101/2023.03.31.533191. PMID: 37034765; PMCID: PMC10081304.

Shanaliz S. Natta

Mentor: Sharon M. Tennant PhD

Allen JC, Natta SS, Nasrin S, Toapanta FR, Tennant SM. Deletion of an immune evasion gene, steD, from a live Salmonella enterica serovar Typhimurium vaccine improves vaccine responses in aged mice. Front Immunol. 2024 Jun 7;15:1376734. doi: 10.3389/fimmu.2024.1376734. PMID: 38911854; PMCID: PMC11190192.

Kevin T.K. Nguyen

Mentors: Braxton D. Mitchell, PhD, MPH, and Steven J. Kittner, MD

Nguyen KT, Xu H, Gaynor B, Adebamowo SN, McArdle PF, O'Connor T, Worrall B, Malik R, Boncoraglio GB, Zand R, Kittner SJ, Mitchell BD. The Impact of Conventional Stroke Risk Factors on Early and Late Onset Ischemic Stroke: a Mendelian Randomization Study. medRxiv [Preprint]. 2024 Jun 2:2024.05.31.24308308. doi: 10.1101/2024.05.31.24308308. PMID: 38853993; PMCID: PMC11160856.

Hou K, Gogarten S, Kim J, Hua X, Dias JA, Sun Q, Wang Y, Tan T; Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Methods Working Group; Atkinson EG, Martin A, Shortt J, Hirbo J, Li Y, Pasaniuc B, Zhang H. Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations. Bioinformatics. 2024 Mar 29;40(4):btae148. doi: 10.1093/bioinformatics/btae148. PMID: 38490256; PMCID: PMC10980565.

Alhassan E, Nguyen K, Hochberg MC, Mitchell BD. Causal Factors for Osteoarthritis: A Scoping Review of Mendelian Randomization Studies. Arthritis Care Res (Hoboken). 2024 Mar;76(3):366-375. doi: 10.1002/acr.25252. Epub 2024 Feb 7. PMID: 37846209; PMCID: PMC10922494.

Nicholas C. Palmateer

Mentor: Joana Carneiro da Silva, PhD

Palmateer NC, Munro JB, Nagaraj S, Crabtree J, Pelle R, Tallon L, Nene V, Bishop R, Silva JC. The Hypervariable Tpr Multigene Family of Theileria Parasites, Defined by a Conserved, Membrane-Associated, C-Terminal Domain, Includes Several Copies with Defined Orthology Between Species. J Mol Evol. 2023 Dec;91(6):897-911. doi: 10.1007/s00239-023-10142-z. Epub 2023 Nov 28. PMID: 38017120; PMCID: PMC10730637.

Nisha R. Pawar

Mentor: Toni M. Antalis, PhD

Pawar NR, Buzza MS, Duru N, Strong AA, Antalis TM. Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis. J Cell Biol. 2023 Nov 6;222(11):e202209114. doi: 10.1083/jcb.202209114. Epub 2023 Sep 22. PMID: 37737895; PMCID: PMC10515437.

Kaylie A. Pinto

Mentors: Christopher W. Ward, PhD

Vanegas C, Ursitti J, Kallenbach JG, Pinto K, Harriot A, Coleman AK, Shi G, Ward CW. Acute microtubule changes linked to DMD pathology are insufficient to impair contractile function or enhance contraction-induced injury in healthy muscle. bioRxiv [Preprint]. 2024 Jun 23:2024.06.19.599775. doi: 10.1101/2024.06.19.599775. PMID: 38948772; PMCID: PMC11212994.

Harriot AD, Altair Morris T, Vanegas C, Kallenbach J, Pinto K, Joca HC, Moutin MJ, Shi G, Ursitti JA, Grosberg A, Ward CW. Detyrosinated microtubule arrays drive myofibrillar malformations in mdx muscle fibers. Front Cell Dev Biol. 2023 Aug 25;11:1209542. doi: 10.3389/fcell.2023.1209542. PMID: 37691825; PMCID: PMC10485621.

Andrea J. Romanowski

Mentor: Alexandros Poulopoulos, PhD

Poulopoulos A, Davis P, Brandenburg C, Itoh Y, Galazo MJ, Greig LC, Romanowski AJ, Budnik B, Macklis JD. Symmetry in levels of axon-axon homophilic adhesion establishes topography in the corpus callosum and development of connectivity between brain hemispheres. bioRxiv [Preprint]. 2024 Mar 31:2024.03.28.587108. doi: 10.1101/2024.03.28.587108. PMID: 38585721; PMCID: PMC10996634.

Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos A. Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses. Biol Psychiatry. 2023 Dec 27:S0006-3223(23)01799-7. doi: 10.1016/j.biopsych.2023.12.020. Epub ahead of print. PMID: 38154503.

Robertson CD, Davis P, Richardson RR, Iffland PH 2nd, Vieira DCO, Steyert M, McKeon PN, Romanowski AJ, Crutcher G, Jašarević E, Wolff SBE, Mathur BN, Crino PB, Bale TL, Dick IE, Poulopoulos A. Rapid modeling of an ultra-rare epilepsy variant in wild-type mice by in utero prime editing. bioRxiv [Preprint]. 2023 Dec 19:2023.12.06.570164. doi: 10.1101/2023.12.06.570164. PMID: 38106154; PMCID: PMC10723435.

Richardson RR, Steyert M, Khim SN, Crutcher GW, Brandenburg C, Robertson CD, Romanowski AJ, Inen J, Altas B, Poulopoulos A. Enhancing Precision and Efficiency of Cas9-Mediated Knockin Through Combinatorial Fusions of DNA Repair Proteins. CRISPR J. 2023 Oct;6(5):447-461. doi: 10.1089/crispr.2023.0036. Epub 2023 Sep 15. PMID: 37713292; PMCID: PMC10611978.

Riccardo Serra

Mentor: Graeme  F. Woodworth, MD

Serra R, Chryssikos T. Decompressive craniectomy incisions: all roads lead to bone. Br J Neurosurg. 2024 Apr 23:1-8. doi: 10.1080/02688697.2024.2344759. Epub ahead of print. PMID: 38651499.

Simard JM, Wilhelmy B, Tsymbalyuk N, Shim B, Stokum JA, Evans M, Gaur A, Tosun C, Keledjian K, Ciryam P, Serra R, Gerzanich V. Brain Swelling versus Infarct Size: A Problematizing Review. Brain Sci. 2024 Feb 28;14(3):229. doi: 10.3390/brainsci14030229. PMID: 38539619; PMCID: PMC10968884.

Serra R, Wilhelmy B, Chen C, Oliver JD, Stokum JA, Bodanapally UK, Simard JM, Schwartzbauer G, Aarabi B. Acute Development of Traumatic Intracranial Aneurysms After Civilian Gunshot Wounds to the Head. J Neurotrauma. 2024 Feb 21. doi: 10.1089/neu.2023.0576. Epub ahead of print. PMID: 38308472.

Olexa J, Walek KW, Flessner R, Trang A, Stokum J, Chen C, Sharma A, Oliver J, Solomon D, Kim KT, Serra R, Ahmed AK, Wilhelmy B, Chryssikos T, Cannarsa G, Crandall K, Sansur C, Schwartzbauer G. The Neurosurgeon's Dilemma-Do Antiplatelet/Anticoagulant Medications Increase the Risk of Catheter-Associated Hemorrhage in External Ventricular Drain Placement? World Neurosurg. 2024 Feb;182:e611-e623. doi: 10.1016/j.wneu.2023.12.001. Epub 2023 Dec 5. PMID: 38061544.

Ahmed AK, Wilhelmy B Jr, Oliver J, Serra R, Chen C, Gandhi D, Eisenberg HM, Labib MA, Woodworth GF. Variability in the Arterial Supply of Intracranial Meningiomas: An Anatomic Study. Neurosurgery. 2023 Dec 1;93(6):1346-1352. doi: 10.1227/neu.0000000000002608. Epub 2023 Aug 2. PMID: 37530524.

Jacob Shaw

Mentor: Ryan M. Pearson, PhD

Truong N, Cottingham AL, Dharmaraj S, Shaw JR, Lasola JJM, Goodis CC, Fletcher S, Pearson RM. Multimodal nanoparticle-containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation. Bioeng Transl Med. 2023 Oct 14;9(1):e10611. doi: 10.1002/btm2.10611. PMID: 38193117; PMCID: PMC10771562.

Scotland BL, Shaw JR, Dharmaraj S, Caprio N, Cottingham AL, Joy Martín Lasola J, Sung JJ, Pearson RM. Cell and biomaterial delivery strategies to induce immune tolerance. Adv Drug Deliv Rev. 2023 Dec;203:115141. doi: 10.1016/j.addr.2023.115141. Epub 2023 Nov 18. PMID: 37980950; PMCID: PMC10842132.

Bosung Shim

Mentor: J. Marc Simard, MD, PhD

Simard JM, Wilhelmy B, Tsymbalyuk N, Shim B, Stokum JA, Evans M, Gaur A, Tosun C, Keledjian K, Ciryam P, Serra R, Gerzanich V. Brain Swelling versus Infarct Size: A Problematizing Review. Brain Sci. 2024 Feb 28;14(3):229. doi: 10.3390/brainsci14030229. PMID: 38539619; PMCID: PMC10968884.

Shim B, Stokum JA, Moyer M, Tsymbalyuk N, Tsymbalyuk O, Keledjian K, Ivanova S, Tosun C, Gerzanich V, Simard JM. Canagliflozin, an Inhibitor of the Na⁺-Coupled D-Glucose Cotransporter, SGLT2, Inhibits Astrocyte Swelling and Brain Swelling in Cerebral Ischemia. Cells. 2023 Sep 6;12(18):2221. doi: 10.3390/cells12182221. PMID: 37759444; PMCID: PMC10527352.

Keledjian K, Makar T, Zhang C, Zhang J, Shim B, Davis H, Bryant J, Gerzanich V, Simard JM, Zhao RY. Correlation of HIV-Induced Neuroinflammation and Synaptopathy with Impairment of Learning and Memory in Mice with HAND. J Clin Med. 2023 Aug 8;12(16):5169. doi: 10.3390/jcm12165169. PMID: 37629211; PMCID: PMC10455390.

Stokum JA, Shim B, Negoita S, Tsymbalyuk N, Tsymbalyuk O, Ivanova S, Keledjian K, Bryan J, Blaustein MP, Jha RM, Kahle KT, Gerzanich V, Simard JM. Cation flux through SUR1-TRPM4 and NCX1 in astrocyte endfeet induces water influx through AQP4 and brain swelling after ischemic stroke. Sci Signal. 2023 Jun 6;16(788):eadd6364. doi: 10.1126/scisignal.add6364. Epub 2023 Jun 6. PMID: 37279286; PMCID: PMC10369355.

Camilo Vanegas

Mentor: Christopher W. Ward, PhD

Vanegas C, Ursitti J, Kallenbach JG, Pinto K, Harriot A, Coleman AK, Shi G, Ward CW. Acute microtubule changes linked to DMD pathology are insufficient to impair contractile function or enhance contraction-induced injury in healthy muscle. bioRxiv [Preprint]. 2024 Jun 23:2024.06.19.599775. doi: 10.1101/2024.06.19.599775. PMID: 38948772; PMCID: PMC11212994.

Harriot AD, Altair Morris T, Vanegas C, Kallenbach J, Pinto K, Joca HC, Moutin MJ, Shi G, Ursitti JA, Grosberg A, Ward CW. Detyrosinated microtubule arrays drive myofibrillar malformations in mdx muscle fibers. Front Cell Dev Biol. 2023 Aug 25;11:1209542. doi: 10.3389/fcell.2023.1209542. PMID: 37691825; PMCID: PMC10485621.

Nicolas Verhoeven

Mentor: Mariusz Karbowski, PhD

Verhoeven N, Oshima Y, Cartier E, Neutzner A, Boyman L, Karbowski M. Outer mitochondrial membrane E3 Ub ligase MARCH5 controls mitochondrial steps in peroxisome biogenesis. bioRxiv [Preprint]. 2023 Sep 1:2023.08.31.555756. doi: 10.1101/2023.08.31.555756. PMID: 37693581; PMCID: PMC10491203.

Karbowski M, Boyman L, Garber L, Joca HC, Verhoeven N, Coleman AK, Ward CW, Lederer WJ, Greiser M. Na ⁺ /K ⁺ ATPase-Ca _v 1.2 nanodomain differentially regulates intracellular [Na ⁺ ], [Ca ²⁺ ] and local adrenergic signaling in cardiac myocytes. bioRxiv [Preprint]. 2023 Sep 2:2023.08.31.553598. doi: 10.1101/2023.08.31.553598. PMID: 37693446; PMCID: PMC10491240.

Greiser M, Karbowski M, Kaplan AD, Coleman AK, Verhoeven N, Mannella CA, Lederer WJ, Boyman L. Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand. Elife. 2023 Jun 5;12:e84204. doi: 10.7554/eLife.84204. PMID: 37272417; PMCID: PMC10284600.

Kaylee Watson

Mentor: Julie C. Dunning-Hotopp, PhD

Mattick JSA, Bromley RE, Watson KJ, Adkins RS, Holt CI, Lebov JF, Sparklin BC, Tyson TS, Rasko DA, Hotopp JCD. Deciphering Bacterial and Archaeal Transcriptional Dark Matter and Its Architectural Complexity. bioRxiv [Preprint]. 2024 Apr 2:2024.04.02.587803. doi: 10.1101/2024.04.02.587803. PMID: 38617363; PMCID: PMC11014543.

Watson KJ, Bromley RE, Sparklin BC, Gasser MT, Bhattacharya T, Lebov JF, Tyson T, Dai N, Teigen LE, Graf KT, Foster JM, Michalski M, Bruno VM, Lindsey AR, Corrêa IR Jr, Hardy RW, Newton IL, Dunning Hotopp JC. Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m⁵C at GCU motifs. Life Sci Alliance. 2023 Nov 29;7(2):e202302201. doi: 10.26508/lsa.202302201. PMID: 38030223; PMCID: PMC10687253.

Jessica C. Allen

Mentor: Sharon M. Tennant, PhD

Allen JC, Natta SS, Nasrin S, Toapanta FR, Tennant SM. Deletion of an immune evasion gene, steD, from a live Salmonella enterica serovar Typhimurium vaccine improves vaccine responses in aged mice. Front

Immunol. 2024 Jun 7;15:1376734. doi: 10.3389/fimmu.2024.1376734. PMID: 38911854; PMCID: PMC11190192.

Jeremy Ardanuy

Mentor: Nicholas H. Carbonetti, PhD

Ardanuy J, Scanlon KM, Skerry C, Carbonetti NH. DNA-Dependent Interferon Induction and Lung Inflammation in Bordetella pertussis Infection. J Interferon Cytokine Res. 2023 Oct;43(10):478-486. doi: 10.1089/jir.2023.0066. Epub 2023 Aug 31. PMID: 37651198; PMCID: PMC10599430.

Jerod A. Brammer

Mentor: Alan S. Cross, MD

Kambouris AR, Brammer JA, Roussey H, Chen C, Cross AS. A combination of burn wound injury and Pseudomonas infection elicits unique gene expression that enhances bacterial pathogenicity. mBio. 2023 Nov 6;14(6):e0245423. doi: 10.1128/mbio.02454-23. Epub ahead of print. PMID: 37929965; PMCID: PMC10746159.

Jillian M. Baker

Mentor: Tim C. Luetkens, MD

Dietze KA, Nguyen K, Pathni A, Fazekas F, Baker JM, Gebru E, Wang A, Sun W, Rosati E, Lum D, Rapoport AP, Fan X, Atanackovic D, Upadhayaya A, Luetkens T. Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function. bioRxiv [Preprint]. 2024 Jun 14:2024.06.11.598379. doi: 10.1101/2024.06.11.598379. PMID: 38915559; PMCID: PMC11195252.

Morales EA, Dietze KA, Baker JM, Wang A, Avila SV, Iglesias F, Radhakrishnan SV, Mause EV, Olson ML, Sun W, Rosati E, Chidester SL, Iraguha T, Fan X, Atanackovic D, Luetkens T. Restricting CAR T Cell Trafficking Expands Targetable Antigen Space. bioRxiv [Preprint]. 2024 Feb 11:2024.02.08.579002. doi: 10.1101/2024.02.08.579002. PMID: 38370665; PMCID: PMC10871312.

Kline K, Luetkens T, Koka R, Kallen ME, Chen W, Ahmad H, Omili D, Iraguha T, Gebru E, Fan X, Miller A, Dishanthan N, Baker JM, Dietze KA, Hankey KG, Yared JA, Hardy NM, Rapoport AP, Dahiya S, Atanackovic D. Treatment of secondary CNS lymphoma using CD19-targeted chimeric antigen receptor (CAR) T cells. Cancer Immunol Immunother. 2024 Feb 13;73(3):45. doi: 10.1007/s00262-023-03619-9. PMID: 38349430; PMCID: PMC10864416.

Atanackovic D, Iraguha T, Omili D, Avila SV, Fan X, Kocoglu M, Gebru E, Baker JM, Dishanthan N, Dietze KA, Oluwafemi A, Hardy NM, Yared JA, Hankey K, Dahiya S, Rapoport AP, Luetkens T. A novel multicolor fluorescent spot assay for the functional assessment of chimeric antigen receptor (CAR) T-cell products. Cytotherapy. 2024 Apr;26(4):318-324. doi: 10.1016/j.jcyt.2024.01.006. Epub 2024 Feb 10. PMID: 38340107.

Kathari YK, Ahmad H, Kallen ME, Koka R, Omili D, Iraguha T, Clement J, Pham L, Khalid M, Fan X, Gebru E, Lesho P, Park E, Dishanthan N, Baker JM, Dietze KA, Hankey KG, Badros A, Yared JA, Dahiya S, Hardy NM, Kocoglu H, Luetkens T, Rapoport AP, Atanackovic D. Immune-mediated facial nerve paralysis in a myeloma patient post B-cell maturation antigen-targeted chimeric antigen receptor T cells. Haematologica. 2024 Feb 1;109(2):682-688. doi: 10.3324/haematol.2023.283296. PMID: 37675514; PMCID: PMC10828766.

Vander Mause ER, Baker JM, Dietze KA, Radhakrishnan SV, Iraguha T, Omili D, Davis P, Chidester SL, Modzelewska K, Panse J, Marvin JE, Olson ML, Steinbach M, Ng DP, Lim CS, Atanackovic D, Luetkens T. Systematic single amino acid affinity tuning of CD229 CAR T cells retains efficacy against multiple myeloma and eliminates on-target off-tumor toxicity. Sci Transl Med. 2023 Jul 19;15(705):eadd7900. doi: 10.1126/scitranslmed.add7900. Epub 2023 Jul 19. PMID: 37467316.

Kline K, Chen W, Kallen ME, Koka R, Omili D, Fan X, Iraguha T, Gebru E, Dishanthan N, Baker JM, Dietze KA, Yared JA, Hankey K, Dahiya S, Niederhaus SV, Dunleavy K, Hardy NM, Luetkens T, Rapoport AP, Atanackovic D. Chimeric antigen receptor (CAR) T cells for the treatment of a kidney transplant patient with post-transplant lymphoproliferative disorder (PTLD). Hum Vaccin Immunother. 2023 Aug 1;19(2):2216116. doi: 10.1080/21645515.2023.2216116. Epub 2023 Jun 6. PMID: 37278257; PMCID: PMC10305491.

L. Rainer Butler

Mentor: Joao H.F. Pedra, PhD

Rolandelli A, Laukaitis-Yousey HJ, Bogale HN, Singh N, Samaddar S, O'Neal AJ, Ferraz CR, Butnaru M, Mameli E, Xia B, Mendes MT, Butler LR, Marnin L, Cabrera Paz FE, Valencia LM, Rana VS, Skerry C, Pal U, Mohr SE, Perrimon N, Serre D, Pedra JHF. Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness. Nat Commun. 2024 Mar 8;15(1):2117. doi: 10.1038/s41467-024-46494-3. PMID: 38459063; PMCID: PMC10923820.

Singh N, Rolandelli A, O'Neal AJ, Butler LR, Samaddar S, Laukaitis-Yousey HJ, Butnaru M, Mohr SE, Perrimon N, Pedra JHF. Genetic manipulation of an Ixodes scapularis cell line. mBio. 2024 Mar 13;15(3):e0247923. doi: 10.1128/mbio.02479-23. Epub 2024 Feb 21. PMID: 38380961; PMCID: PMC10936194.

Butler LR, Singh N, Marnin L, Valencia LM, O'Neal AJ, Paz FEC, Shaw DK, Chavez ASO, Pedra JHF. The role of Rab27 in tick extracellular vesicle biogenesis and pathogen infection. Parasit Vectors. 2024 Feb 9;17(1):57. doi: 10.1186/s13071-024-06150-7. PMID: 38336752; PMCID: PMC10854084.

Marnin L, Bogale HN, Laukaitis-Yousey HJ, Valencia LM, Rolandelli A, O'Neal AJ, Ferraz CR, Schmitter-Sánchez AD, Cuevas EB, Nguyen TT, Leal-Galvan B, Rickert DM, Bruno VM, Tays Mendes M, Samaddar S, Rainer Butler L, Singh N, Cabrera Paz FE, Oliver JD, Jameson JM, Munderloh UG, Oliva Chávez AS, Mulenga A, Park S, Serre D, Pedra JHF. Tick extracellular vesicles impair epidermal homeostasis through immune-epithelial networks during hematophagy. bioRxiv [Preprint]. 2023 Nov 10:2023.11.10.566612. doi: 10.1101/2023.11.10.566612. PMID: 37986907; PMCID: PMC10659423.

Kenneth A. Dietze

Mentor: Tim C. Luetkens, MD

Dietze KA, Nguyen K, Pathni A, Fazekas F, Baker JM, Gebru E, Wang A, Sun W, Rosati E, Lum D, Rapoport AP, Fan X, Atanackovic D, Upadhayaya A, Luetkens T. Preventing trogocytosis by cathepsin B inhibition augments CAR T cell function. bioRxiv [Preprint]. 2024 Jun 14:2024.06.11.598379. doi: 10.1101/2024.06.11.598379. PMID: 38915559; PMCID: PMC11195252.

Morales EA, Dietze KA, Baker JM, Wang A, Avila SV, Iglesias F, Radhakrishnan SV, Mause EV, Olson ML, Sun W, Rosati E, Chidester SL, Iraguha T, Fan X, Atanackovic D, Luetkens T. Restricting CAR T Cell Trafficking Expands Targetable Antigen Space. bioRxiv [Preprint]. 2024 Feb 11:2024.02.08.579002. doi: 10.1101/2024.02.08.579002. PMID: 38370665; PMCID: PMC10871312.

Kline K, Luetkens T, Koka R, Kallen ME, Chen W, Ahmad H, Omili D, Iraguha T, Gebru E, Fan X, Miller A, Dishanthan N, Baker JM, Dietze KA, Hankey KG, Yared JA, Hardy NM, Rapoport AP, Dahiya S, Atanackovic D. Treatment of secondary CNS lymphoma using CD19-targeted chimeric antigen receptor (CAR) T cells. Cancer Immunol Immunother. 2024 Feb 13;73(3):45. doi: 10.1007/s00262-023-03619-9. PMID: 38349430; PMCID: PMC10864416.

Atanackovic D, Iraguha T, Omili D, Avila SV, Fan X, Kocoglu M, Gebru E, Baker JM, Dishanthan N, Dietze KA, Oluwafemi A, Hardy NM, Yared JA, Hankey K, Dahiya S, Rapoport AP, Luetkens T. A novel multicolor fluorescent spot assay for the functional assessment of chimeric antigen receptor (CAR) T-cell products. Cytotherapy. 2024 Apr;26(4):318-324. doi: 10.1016/j.jcyt.2024.01.006. Epub 2024 Feb 10. PMID: 38340107.

Kathari YK, Ahmad H, Kallen ME, Koka R, Omili D, Iraguha T, Clement J, Pham L, Khalid M, Fan X, Gebru E, Lesho P, Park E, Dishanthan N, Baker JM, Dietze KA, Hankey KG, Badros A, Yared JA, Dahiya S, Hardy NM, Kocoglu H, Luetkens T, Rapoport AP, Atanackovic D. Immune-mediated facial nerve paralysis in a myeloma patient post B-cell maturation antigen-targeted chimeric antigen receptor T cells. Haematologica. 2024 Feb 1;109(2):682-688. doi: 10.3324/haematol.2023.283296. PMID: 37675514; PMCID: PMC10828766.

Vander Mause ER, Baker JM, Dietze KA, Radhakrishnan SV, Iraguha T, Omili D, Davis P, Chidester SL, Modzelewska K, Panse J, Marvin JE, Olson ML, Steinbach M, Ng DP, Lim CS, Atanackovic D, Luetkens T. Systematic single amino acid affinity tuning of CD229 CAR T cells retains efficacy against multiple myeloma and eliminates on-target off-tumor toxicity. Sci Transl Med. 2023 Jul 19;15(705):eadd7900. doi: 10.1126/scitranslmed.add7900. Epub 2023 Jul 19. PMID: 37467316.

Kline K, Chen W, Kallen ME, Koka R, Omili D, Fan X, Iraguha T, Gebru E, Dishanthan N, Baker JM, Dietze KA, Yared JA, Hankey K, Dahiya S, Niederhaus SV, Dunleavy K, Hardy NM, Luetkens T, Rapoport AP, Atanackovic D. Chimeric antigen receptor (CAR) T cells for the treatment of a kidney transplant patient with post-transplant lymphoproliferative disorder (PTLD). Hum Vaccin Immunother. 2023 Aug 1;19(2):2216116. doi: 10.1080/21645515.2023.2216116. Epub 2023 Jun 6. PMID: 37278257; PMCID: PMC10305491.

Caitlin Gabor

Mentors: Eileen M. Barry, PhD and David Rasko, PhD

Gabor CE, Hazen TH, Delaine-Elias BC, Rasko DA, Barry EM. Genomic, transcriptomic, and phenotypic differences among archetype Shigella flexneri strains of serotypes 2a, 3a, and 6. mSphere. 2023 Dec 20;8(6):e0040823. doi: 10.1128/msphere.00408-23. Epub 2023 Oct 13. PMID: 37830809; PMCID: PMC10732043.

Smith EM, Papadimas A, Gabor C, Cooney C, Wu T, Rasko D, Barry EM. The role of the minor colonization factor CS14 in adherence to intestinal cell models by geographically diverse ETEC isolates. mSphere. 2023 Oct 24;8(5):e0030223. doi: 10.1128/msphere.00302-23. Epub 2023 Oct 3. PMID: 37787523; PMCID: PMC10597352.

Corbin E. Goerlich

Mentor: Muhammad M. Mohiuddin, MBBS

Mohiuddin MM, Singh AK, Scobie L, Goerlich CE, Grazioli A, Saharia K, Crossan C, Burke A, Drachenberg C, Oguz C, Zhang T, Lewis B, Hershfeld A, Sentz F, Tatarov I, Mudd S, Braileanu G, Rice K, Paolini JF, Bondensgaard K, Vaught T, Kuravi K, Sorrells L, Dandro A, Ayares D, Lau C, Griffith BP. Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report. Lancet. 2023 Jul 29;402(10399):397-410. doi: 10.1016/S0140-6736(23)00775-4. Epub 2023 Jun 29. PMID: 37393920; PMCID: PMC10552929.

Elizabeth M. Hill

Mentor: Nevil J. Singh, PhD

Boughter CT, Chatterjee B, Ohta Y, Gorga K, Blair C, Hill EM, Fasana Z, Adebamowo A, Ammar F, Kosik I, Murugan V, Chen WH, Singh NJ, Meier-Schellersheim M. CountASAP: A Lightweight, Easy to Use Python Package for Processing ASAPseq Data. bioRxiv [Preprint]. 2024 May 22:2024.05.20.595042. doi: 10.1101/2024.05.20.595042. PMID: 38903111; PMCID: PMC11188107.

Cissé YM, Montgomery KR, Zierden HC, Hill EM, Kane PJ, Huang W, Kane MA, Bale TL. Maternal preconception stress produces sex-specific effects at the maternal:fetal interface to impact offspring development and phenotypic outcomes†. Biol Reprod. 2024 Feb 10;110(2):339-354. doi: 10.1093/biolre/ioad156. PMID: 37971364; PMCID: PMC10873277.

Thomas D. Hill

Mentor: Helen M. Dooley, PhD

Matz H, Taylor RS, Redmond AK, Hill TM, Ruiz Daniels R, Beltran M, Henderson NC, Macqueen DJ, Dooley H. Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers. Cell Rep. 2023 Jul 25;42(7):112664. doi: 10.1016/j.celrep.2023.112664. Epub 2023 Jun 20. PMID: 37342909; PMCID: PMC10529500.

Casey Hofstaedter

Mentor: Robert K. Ernst, PhD

Hofstaedter CE, O'Keefe IP, Met CM, Wu L, Vanderwoude J, Shin S, Diggle SP, Riquelme SA, Rasko DA, Doi Y, Harro JM, Kopp BT, Ernst RK. Pseudomonas aeruginosa Lipid A Structural Variants Induce Altered Immune Responses. Am J Respir Cell Mol Biol. 2024 Apr 24. doi: 10.1165/rcmb.2024-0059OC. Epub ahead of print. PMID: 38656811.

Hofstaedter CE, Chandler CE, Met CM, Gillespie JJ, Harro JM, Goodlett DR, Rasko DA, Ernst RK. Divergent Pseudomonas aeruginosa LpxO enzymes perform site-specific lipid A 2-hydroxylation. mBio. 2024 Feb 14;15(2):e0282323. doi: 10.1128/mbio.02823-23. Epub 2023 Dec 22. PMID: 38131669; PMCID: PMC10865791.

Hofstaedter CE, Watkins R, Kotwal N. Asymptomatic Esophageal Eosinophilia in an 11-Year-Old with Severe Persistent Asthma. Case Rep Pediatr. 2023 Oct 12;2023:6678918. doi: 10.1155/2023/6678918. PMID: 37868770; PMCID: PMC10586919.

Tomlinson KL, Chen YT, Junker A, Urso A, Wong Fok Lung T, Ahn D, Hofstaedter CE, Baskota SU, Ernst RK, Prince A, Riquelme SA. Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection. Cell Metab. 2023 Oct 3;35(10):1767-1781.e6. doi: 10.1016/j.cmet.2023.09.001. PMID: 37793346; PMCID: PMC10558090.

Scott AJ, Ellis SR, Hofstaedter CE, Heeren RMA, Ernst RK. Spatial lipidomics reveals biased phospholipid remodeling in acute Pseudomonas lung infection. iScience. 2023 Aug 21;26(9):107700. doi: 10.1016/j.isci.2023.107700. PMID: 37680478; PMCID: PMC10480615.

Chandler CE, Hofstaedter CE, Hazen TH, Rasko DA, Ernst RK. Genomic and Functional Characterization of Longitudinal Pseudomonas aeruginosa Isolates from Young Patients with Cystic Fibrosis. Microbiol Spectr. 2023 Aug 17;11(4):e0155623. doi: 10.1128/spectrum.01556-23. Epub 2023 Jun 26. PMID: 37358436; PMCID: PMC10433850.

Da'Kuawn Johnson

Mentor: Nicholas H. Carbonetti, PhD

Johnson D, Carbonetti N. Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections. J Interferon Cytokine Res. 2023 Sep;43(9):363-369. doi: 10.1089/jir.2023.0037. Epub 2023 Jun 8. PMID: 37289801; PMCID: PMC10517327.

Adrienne R. Kambouris

Mentor: Alan S. Cross, MD

Kambouris AR, Brammer JA, Roussey H, Chen C, Cross AS. A combination of burn wound injury and Pseudomonas infection elicits unique gene expression that enhances bacterial pathogenicity. mBio. 2023 Nov 6;14(6):e0245423. doi: 10.1128/mbio.02454-23. Epub ahead of print. PMID: 37929965; PMCID: PMC10746159.

Christina Kratzemeier

Mentor: Alexander S. Krupnik, MD

Mei Z, Khalil MA, Guo Y, Li D, Banerjee A, Terada Y, Yokoyama Y, Kratzmeier C, Chen K, Li L, Lau CL, Courneya JP, Luzina IG, Atamas SP, Gelman AE, Kreisel D, Jacobsen EA, Krupnick AS. Eosinophils restrain humoral alloimmunity after lung transplantation. JCI Insight. 2024 Feb 8;9(3):e168911. doi: 10.1172/jci.insight.168911. PMID: 38329123; PMCID: PMC10967387.

Jackline Joy Lasola

Mentor: Ryan M. Pearson, PhD

Scotland BL, Cottingham AL, Lasola JJM, Hoag SW, Pearson RM. Development of protein-polymer conjugate nanoparticles for modulation of dendritic cell phenotype and antigen-specific CD4 T cell responses. ACS Appl Polym Mater. 2023 Nov 10;5(11):8794-8807. doi: 10.1021/acsapm.3c00548. Epub 2023 Oct 9. PMID: 38911349; PMCID: PMC11192461.

Truong N, Cottingham AL, Dharmaraj S, Shaw JR, Lasola JJM, Goodis CC, Fletcher S, Pearson RM. Multimodal nanoparticle-containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation. Bioeng Transl Med. 2023 Oct 14;9(1):e10611. doi: 10.1002/btm2.10611. PMID: 38193117; PMCID: PMC10771562.

James P. Logue

Mentor: Matthew B. Frieman, PhD

Wang B, Shen WB, Townsel C, Baracco L, Logue J, Reece EA, Frieman MB, Yang P. Placental SARS-CoV-2 Infection and Its Implications for Increased Risk of Adverse Pregnancy Outcomes. Am J Perinatol. 2024 Jun 10. doi: 10.1055/a-2323-0854. Epub ahead of print. PMID: 38729183.

Logue J, Melville VM, Ardanuy J, Frieman MB. CNP blocks mitochondrial depolarization and inhibits SARS-CoV-2 replication in vitro and in vivo. PLoS Pathog. 2023 Dec 20;19(12):e1011870. doi: 10.1371/journal.ppat.1011870. PMID: 38117830; PMCID: PMC10766180.

Jassey A, Logue J, Weston S, Wagner MA, Galitska G, Miller K, Frieman M, Jackson WT. SIRT-1 is required for release of enveloped enteroviruses. Elife. 2023 Oct 18;12:RP87993. doi: 10.7554/eLife.87993. PMID: 37850626; PMCID: PMC10584371.

Johnson RM, Ardanuy J, Hammond H, Logue J, Jackson L, Baracco L, McGrath M, Dillen C, Patel N, Smith G, Frieman M. Diet-induced obesity and diabetes enhance mortality and reduce vaccine efficacy for SARS-CoV-2. J Virol. 2023 Nov 30;97(11):e0133623. doi: 10.1128/jvi.01336-23. Epub 2023 Oct 17. PMID: 37846985; PMCID: PMC10688338.

Michael S. Lee

Mentor: Tonya J. Webb, PhD

Lee MS, Webb TJ. Novel lipid antigens for NKT cells in cancer. Front Immunol. 2023 Oct 16;14:1173375. doi: 10.3389/fimmu.2023.1173375. PMID: 37908366; PMCID: PMC10613688.

Liron Marnin

Mentor: Joao H.F. Pedra, PhD

Rolandelli A, Laukaitis-Yousey HJ, Bogale HN, Singh N, Samaddar S, O'Neal AJ, Ferraz CR, Butnaru M, Mameli E, Xia B, Mendes MT, Butler LR, Marnin L, Cabrera Paz FE, Valencia LM, Rana VS, Skerry C, Pal U, Mohr SE, Perrimon N, Serre D, Pedra JHF. Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness. Nat Commun. 2024 Mar 8;15(1):2117. doi: 10.1038/s41467-024-46494-3. PMID: 38459063; PMCID: PMC10923820.

Butler LR, Singh N, Marnin L, Valencia LM, O'Neal AJ, Paz FEC, Shaw DK, Chavez ASO, Pedra JHF. The role of Rab27 in tick extracellular vesicle biogenesis and pathogen infection. Parasit Vectors. 2024 Feb 9;17(1):57. doi: 10.1186/s13071-024-06150-7. PMID: 38336752; PMCID: PMC10854084.

Marnin L, Bogale HN, Laukaitis-Yousey HJ, Valencia LM, Rolandelli A, O'Neal AJ, Ferraz CR, Schmitter-Sánchez AD, Cuevas EB, Nguyen TT, Leal-Galvan B, Rickert DM, Bruno VM, Tays Mendes M, Samaddar S, Rainer Butler L, Singh N, Cabrera Paz FE, Oliver JD, Jameson JM, Munderloh UG, Oliva Chávez AS, Mulenga A, Park S, Serre D, Pedra JHF. Tick extracellular vesicles impair epidermal homeostasis through immune-epithelial networks during hematophagy. bioRxiv [Preprint]. 2023 Nov 10:2023.11.10.566612. doi: 10.1101/2023.11.10.566612. PMID: 37986907; PMCID: PMC10659423.

Hanover Matz

Mentor: Helen M. Dooley, PhD

Matz H, Dooley H. 450 million years in the making: mapping the evolutionary foundations of germinal centers. Front Immunol. 2023 Aug 11;14:1245704. doi: 10.3389/fimmu.2023.1245704. PMID: 37638014; PMCID: PMC10450919.

Srinivasan Rajsri K, McRae MP, Christodoulides NJ, Dapkins I, Simmons GW, Matz H, Dooley H, Fenyö D, McDevitt JT. Simultaneous Quantitative SARS-CoV-2 Antigen and Host Antibody Detection and Pre-Screening Strategy at the Point of Care. Bioengineering (Basel). 2023 Jun 1;10(6):670. doi: 10.3390/bioengineering10060670. PMID: 37370601; PMCID: PMC10295356.

Matz H, Taylor RS, Redmond AK, Hill TM, Ruiz Daniels R, Beltran M, Henderson NC, Macqueen DJ, Dooley H. Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers. Cell Rep. 2023 Jul 25;42(7):112664. doi: 10.1016/j.celrep.2023.112664. Epub 2023 Jun 20. PMID: 37342909; PMCID: PMC10529500.

Gillian Mbambo

Mentor: Joana Carneiro Da Silva, PhD

Mbambo G, Dwivedi A, Ifeonu OO, Munro JB, Shrestha B, Bromley RE, Hodges T, Adkins RS, Kouriba B, Diarra I, Niangaly A, Kone AK, Coulibaly D, Traore K, Dolo A, Thera MA, Laurens MB, Doumbo OK, Plowe CV, Berry AA, Travassos M, Lyke KE, Silva JC. Immunogenomic profile at baseline predicts host susceptibility to clinical malaria. Front Immunol. 2023 Jul 3;14:1179314. doi: 10.3389/fimmu.2023.1179314. PMID: 37465667; PMCID: PMC10351378.

Marisa E. McGrath

Mentor: Matthew B. Frieman, PhD

McGrath ME, Xue Y, Taylor L, Dillen C, Ardanuy J, Gonzalez-Juarbe N, Baracco L, Kim R, Hart R, Assad-Garcia N, Vashee S, Frieman MB. SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression. PLoS Pathog. 2024 May 23;20(5):e1011669. doi: 10.1371/journal.ppat.1011669. PMID: 38781259; PMCID: PMC11152254.

Johnson RM, Ardanuy J, Hammond H, Logue J, Jackson L, Baracco L, McGrath M, Dillen C, Patel N, Smith G, Frieman M. Diet-induced obesity and diabetes enhance mortality and reduce vaccine efficacy for SARS-CoV-2. J Virol. 2023 Nov 30;97(11):e0133623. doi: 10.1128/jvi.01336-23. Epub 2023 Oct 17. PMID: 37846985; PMCID: PMC10688338.

O'Meara TR, Nanishi E, McGrath ME, Barman S, Dong D, Dillen C, Menon M, Seo HS, Dhe-Paganon S, Ernst RK, Levy O, Frieman MB, Dowling DJ. Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. J Allergy Clin Immunol. 2023 Nov;152(5):1107-1120.e6. doi: 10.1016/j.jaci.2023.06.031. Epub 2023 Aug 16. PMID: 37595760; PMCID: PMC10841117.

Li M, Ayyanathan K, Dittmar M, Miller J, Tapescu I, Lee JS, McGrath ME, Xue Y, Vashee S, Schultz DC, Frieman MB, Cherry S. SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection. mBio. 2023 Aug 31;14(4):e0119423. doi: 10.1128/mbio.01194-23. Epub 2023 Jun 28. PMID: 37377442; PMCID: PMC10470815.

Ashley E. Mitchell

Mentor: Nicholas H. Carbonetti, PhD

Mitchell AE, Scanlon KM, Flowers EM, Jordan CM, Tibbs EJ, Bukowski A, Gallop D, Carbonetti NH. Age-dependent natural killer cell and interferon γ deficits contribute to severe pertussis in infant mice. J Leukoc Biol. 2024 May 29;115(6):1143-1153. doi: 10.1093/jleuko/qiae020. PMID: 38285898; PMCID: PMC11135619.

Anya J. O'Neal

Mentor: Joao H.F. Pedra, PhD

Rolandelli A, Laukaitis-Yousey HJ, Bogale HN, Singh N, Samaddar S, O'Neal AJ, Ferraz CR, Butnaru M, Mameli E, Xia B, Mendes MT, Butler LR, Marnin L, Cabrera Paz FE, Valencia LM, Rana VS, Skerry C, Pal U, Mohr SE, Perrimon N, Serre D, Pedra JHF. Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness. Nat Commun. 2024 Mar 8;15(1):2117. doi: 10.1038/s41467-024-46494-3. PMID: 38459063; PMCID: PMC10923820.

Singh N, Rolandelli A, O'Neal AJ, Butler LR, Samaddar S, Laukaitis-Yousey HJ, Butnaru M, Mohr SE, Perrimon N, Pedra JHF. Genetic manipulation of an Ixodes scapularis cell line. mBio. 2024 Mar 13;15(3):e0247923. doi: 10.1128/mbio.02479-23. Epub 2024 Feb 21. PMID: 38380961; PMCID: PMC10936194.

Butler LR, Singh N, Marnin L, Valencia LM, O'Neal AJ, Paz FEC, Shaw DK, Chavez ASO, Pedra JHF. The role of Rab27 in tick extracellular vesicle biogenesis and pathogen infection. Parasit Vectors. 2024 Feb 9;17(1):57. doi: 10.1186/s13071-024-06150-7. PMID: 38336752; PMCID: PMC10854084.

Marnin L, Bogale HN, Laukaitis-Yousey HJ, Valencia LM, Rolandelli A, O'Neal AJ, Ferraz CR, Schmitter-Sánchez AD, Cuevas EB, Nguyen TT, Leal-Galvan B, Rickert DM, Bruno VM, Tays Mendes M, Samaddar S, Rainer Butler L, Singh N, Cabrera Paz FE, Oliver JD, Jameson JM, Munderloh UG, Oliva Chávez AS, Mulenga A, Park S, Serre D, Pedra JHF. Tick extracellular vesicles impair epidermal homeostasis through immune-epithelial networks during hematophagy. bioRxiv [Preprint]. 2023 Nov 10:2023.11.10.566612. doi: 10.1101/2023.11.10.566612. PMID: 37986907; PMCID: PMC10659423.

Shil Patel

Mentor: Nevil J. Singh, PhD

Chopp LB, Zhu X, Gao Y, Nie J, Singh J, Kumar P, Young KZ, Patel S, Li C, Balmaceno-Criss M, Vacchio MS, Wang MM, Livak F, Merchant JL, Wang L, Kelly MC, Zhu J, Bosselut R. Zfp281 and Zfp148 control CD4⁺ T cell thymic development and T_H2 functions. Sci Immunol. 2023 Nov 10;8(89):eadi9066. doi: 10.1126/sciimmunol.adi9066. Epub 2023 Nov 10. PMID: 37948511.

Noah Pollack

Mentor: William T. Jackson, PhD

Jassey A, Pollack N, Wagner MA, Wu J, Benton A, Jackson WT. Transcription factor EB (TFEB) interaction with RagC is disrupted during enterovirus D68 infection. J Virol. 2024 Jun 18:e0055624. doi: 10.1128/jvi.00556-24. Epub ahead of print. PMID: 38888347.

Galitska G, Jassey A, Wagner MA, Pollack N, Miller K, Jackson WT. Enterovirus D68 capsid formation and stability requires acidic compartments. mBio. 2023 Oct 31;14(5):e0214123. doi: 10.1128/mbio.02141-23. Epub 2023 Oct 11. PMID: 37819109; PMCID: PMC10653823.

David T. Rach

Mentors: Cristiana Cairo, PhD and Kirsten E. Lyke, MD

Hsu H, Zanettini C, Coker M, Boudova S, Rach D, Mvula G, Divala TH, Mungwira RG, Boldrin F, Degiacomi G, Mazzabò LC, Manganelli R, Laufer MK, Zhang Y, Marchionni L, Cairo C. Concomitant assessment of PD-1 and CD56 expression identifies subsets of resting cord blood Vδ2 T cells with disparate cytotoxic potential. Cell Immunol. 2024 Jan-Feb;395-396:104797. doi: 10.1016/j.cellimm.2023.104797. Epub 2023 Dec 23. PMID: 38157646.

David M. Rickert

Mentor: Nicholas H. Carbonetti, PhD

Ferrer P, Berry AA, Bucsan AN, Prajapati SK, Krishnan K, Barbeau MC, Rickert DM, Guerrero SM, Usui M, Abebe Y, Patil A, Chakravarty S, Billingsley PF, Pa'ahana-Brown F, Strauss K, Shrestha B, Nomicos E, Deye GA, Sim BKL, Hoffman SL, Williamson KC, Lyke KE. Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms. Nat Commun. 2024 Jun 18;15(1):5194. doi: 10.1038/s41467-024-49041-2. PMID: 38890271; PMCID: PMC11189388.

Marnin L, Bogale HN, Laukaitis-Yousey HJ, Valencia LM, Rolandelli A, O'Neal AJ, Ferraz CR, Schmitter-Sánchez AD, Cuevas EB, Nguyen TT, Leal-Galvan B, Rickert DM, Bruno VM, Tays Mendes M, Samaddar S, Rainer Butler L, Singh N, Cabrera Paz FE, Oliver JD, Jameson JM, Munderloh UG, Oliva Chávez AS, Mulenga A, Park S, Serre D, Pedra JHF. Tick extracellular vesicles impair epidermal homeostasis through immune-epithelial networks during hematophagy. bioRxiv [Preprint]. 2023 Nov 10:2023.11.10.566612. doi: 10.1101/2023.11.10.566612. PMID: 37986907; PMCID: PMC10659423.

Cosette Schneider

Mentor: Lynda Coughland, PhD

Schneider C, Coughlan L. Always a bridesmaid, never a bride: Committing to flu neuraminidase as a vaccine target. Mol Ther. 2023 Jul 5;31(7):1865-1867. doi: 10.1016/j.ymthe.2023.04.014. Epub 2023 May 17. PMID: 37201525; PMCID: PMC10362412.

Michael J. Sikorski

Mentors: Myron M. Levine, MD, DTPH and David A. Rasko, PhD

Lagos RM, Sikorski MJ, Hormazábal JC, Fernandez A, Duarte S, Pasetti MF, Rasko DA, Higginson E, Nkeze J, Kasumba IN, Dougan G, Maes M, Lees A, Tennant SM, Levine MM. Detecting residual chronic Salmonella Typhi carriers on the road to typhoid elimination in Santiago, Chile, 2017-2019. J Infect Dis. 2023 Dec 20:jiad585. doi: 10.1093/infdis/jiad585. Epub ahead of print. PMID: 38123455.

Martin LB, Khanam F, Qadri F, Khalil I, Sikorski MJ, Baker S. Vaccine value profile for Salmonella enterica serovar Paratyphi A. Vaccine. 2023 Nov 3;41 Suppl 2:S114-S133. doi: 10.1016/j.vaccine.2023.01.054. Epub 2023 Oct 6. PMID: 37951691.

Carey ME, Dyson ZA, Ingle DJ, Amir A, Aworh MK, Chattaway MA, Chew KL, Crump JA, Feasey NA, Howden BP, Keddy KH, Maes M, Parry CM, Van Puyvelde S, Webb HE, Afolayan AO, Alexander AP, Anandan S, Andrews JR, Ashton PM, Basnyat B, Bavdekar A, Bogoch II, Clemens JD, da Silva KE, De A, de Ligt J, Diaz Guevara PL, Dolecek C, Dutta S, Ehlers MM, Francois Watkins L, Garrett DO, Godbole G, Gordon MA, Greenhill AR, Griffin C, Gupta M, Hendriksen RS, Heyderman RS, Hooda Y, Hormazabal JC, Ikhimiukor OO, Iqbal J, Jacob JJ, Jenkins C, Jinka DR, John J, Kang G, Kanteh A, Kapil A, Karkey A, Kariuki S, Kingsley RA, Koshy RM, Lauer AC, Levine MM, Lingegowda RK, Luby SP, Mackenzie GA, Mashe T, Msefula C, Mutreja A, Nagaraj G, Nagaraj S, Nair S, Naseri TK, Nimarota-Brown S, Njamkepo E, Okeke IN, Perumal SPB, Pollard AJ, Pragasam AK, Qadri F, Qamar FN, Rahman SIA, Rambocus SD, Rasko DA, Ray P, Robins-Browne R, Rongsen-Chandola T, Rutanga JP, Saha SK, Saha S, Saigal K, Sajib MSI, Seidman JC, Shakya J, Shamanna V, Shastri J, Shrestha R, Sia S, Sikorski MJ, Singh A, Smith AM, Tagg KA, Tamrakar D, Tanmoy AM, Thomas M, Thomas MS, Thomsen R, Thomson NR, Tupua S, Vaidya K, Valcanis M, Veeraraghavan B, Weill FX, Wright J, Dougan G, Argimón S, Keane JA, Aanensen DM, Baker S, Holt KE; Global Typhoid Genomics Consortium Group Authorship. Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes. Elife. 2023 Sep 12;12:e85867. doi: 10.7554/eLife.85867. PMID: 37697804; PMCID: PMC10506625.

Raees MQ, Chimalizeni Y, Liomba AWM, Pensulo P, Gushu MB, Tebulo A, Malenga A, Sikorski MJ, Holloway AJ, Bhutta AT, Doctor A, Remy KE, O'Brien NF, Postels DG, Taylor TE. Capacity Building in Pediatric Critical Care-Global Health Research and Education: The Blantyre Experience. Am J Trop Med Hyg. 2023 Jun 12;109(2):225-227. doi: 10.4269/ajtmh.22-0445. PMID: 37308102; PMCID: PMC10397452.

Emily M. Smith

Mentor: Eileen M. Barry, PhD

Smith EM, Papadimas A, Gabor C, Cooney C, Wu T, Rasko D, Barry EM. The role of the minor colonization factor CS14 in adherence to intestinal cell models by geographically diverse ETEC isolates. mSphere. 2023 Oct 24;8(5):e0030223. doi: 10.1128/msphere.00302-23. Epub 2023 Oct 3. PMID: 37787523; PMCID: PMC10597352.

Alexandra Y. Soare

Mentor: Vincent M. Bruno, PhD

Soare AY, Bruno VM. Mucorales fungi suppress nitric oxide production by macrophages. mBio. 2024 Jan 16;15(1):e0284823. doi: 10.1128/mbio.02848-23. Epub 2023 Dec 14. PMID: 38095437; PMCID: PMC10790689.

Kieran E. Tebben

Mentor: David Serre, Dr. rer. nat

Tebben K, Yirampo S, Coulibaly D, Koné AK, Laurens MB, Stucke EM, Dembélé A, Tolo Y, Traoré K, Niangaly A, Berry AA, Kouriba B, Plowe CV, Doumbo OK, Lyke KE, Takala-Harrison S, Thera MA, Travassos MA, Serre D. Gene expression analyses reveal differences in children's response to malaria according to their age. Nat Commun. 2024 Mar 6;15(1):2021. doi: 10.1038/s41467-024-46416-3. PMID: 38448421; PMCID: PMC10918175.

Ellis J. Tibbs

Mentor: Xuefang Cao, PhD

Guasch FM, Sajjan S, Tibbs E, Reandeau C, Wu L, Bohlen J, Li A, Plotkin A, Cao X, Sunshine SB. A novel severity scoring system for murine ocular graft versus host disease and its correlation with CD3+ T cells in the cornea. Ocul Surf. 2024 Jul;33:77-79. doi: 10.1016/j.jtos.2024.05.003. Epub 2024 May 31. PMID: 38823677.

Mitchell AE, Scanlon KM, Flowers EM, Jordan CM, Tibbs EJ, Bukowski A, Gallop D, Carbonetti NH. Age-dependent natural killer cell and interferon γ deficits contribute to severe pertussis in infant mice. J Leukoc Biol. 2024 May 29;115(6):1143-1153. doi: 10.1093/jleuko/qiae020. PMID: 38285898; PMCID: PMC11135619.

Luisa M. Valencia Valencia

Mentor: Joao H.F. Pedra, PhD

Rolandelli A, Laukaitis-Yousey HJ, Bogale HN, Singh N, Samaddar S, O'Neal AJ, Ferraz CR, Butnaru M, Mameli E, Xia B, Mendes MT, Butler LR, Marnin L, Cabrera Paz FE, Valencia LM, Rana VS, Skerry C, Pal U, Mohr SE, Perrimon N, Serre D, Pedra JHF. Tick hemocytes have a pleiotropic role in microbial infection and arthropod fitness. Nat Commun. 2024 Mar 8;15(1):2117. doi: 10.1038/s41467-024-46494-3. PMID: 38459063; PMCID: PMC10923820.

Butler LR, Singh N, Marnin L, Valencia LM, O'Neal AJ, Paz FEC, Shaw DK, Chavez ASO, Pedra JHF. The role of Rab27 in tick extracellular vesicle biogenesis and pathogen infection. Parasit Vectors. 2024 Feb 9;17(1):57. doi: 10.1186/s13071-024-06150-7. PMID: 38336752; PMCID: PMC10854084.

Marnin L, Bogale HN, Laukaitis-Yousey HJ, Valencia LM, Rolandelli A, O'Neal AJ, Ferraz CR, Schmitter-Sánchez AD, Cuevas EB, Nguyen TT, Leal-Galvan B, Rickert DM, Bruno VM, Tays Mendes M, Samaddar S, Rainer Butler L, Singh N, Cabrera Paz FE, Oliver JD, Jameson JM, Munderloh UG, Oliva Chávez AS, Mulenga A, Park S, Serre D, Pedra JHF. Tick extracellular vesicles impair epidermal homeostasis through immune-epithelial networks during hematophagy. bioRxiv [Preprint]. 2023 Nov 10:2023.11.10.566612. doi: 10.1101/2023.11.10.566612. PMID: 37986907; PMCID: PMC10659423.

Alexandra M. Vlk

Mentor: Stefanie N. Vogel, PhD

Vlk AM, Prantner D, Shirey KA, Perkins DJ, Buzza MS, Thumbigere-Math V, Keegan AD, Vogel SN. M2a macrophages facilitate resolution of chemically-induced colitis in TLR4-SNP mice. mBio. 2023 Oct 31;14(5):e0120823. doi: 10.1128/mbio.01208-23. Epub 2023 Sep 28. PMID: 37768050; PMCID: PMC10653841.

Jiapeng Wu

Mentor: Lishan Su, PhD

Jassey A, Pollack N, Wagner MA, Wu J, Benton A, Jackson WT. Transcription factor EB (TFEB) interaction with RagC is disrupted during enterovirus D68 infection. J Virol. 2024 Jul 23;98(7):e0055624. doi: 10.1128/jvi.00556-24. Epub 2024 Jun 18. PMID: 38888347; PMCID: PMC11265353.

Ahodantin J, Wu J, Funaki M, Flores J, Wang X, Zheng P, Liu Y, Su L. Siglec-H-/- Plasmacytoid Dendritic Cells Protect Against Acute Liver Injury by Suppressing IFN-γ/Th1 Response and Promoting IL-21+ CD4 T Cells. Cell Mol Gastroenterol Hepatol. 2024 Jun 6;18(3):101367. doi: 10.1016/j.jcmgh.2024.101367. Epub ahead of print. PMID: 38849082.

Jason B. Alipio

Mentor: Asaf Keller, PhD

Olusakin J, Kumar G, Basu M, Calarco CA, Fox ME, Alipio JB, Haga C, Turner MD, Keller A, Ament SA, Lobo MK. Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice. Neuropsychopharmacology. 2023 Nov;48(12):1724-1734. doi: 10.1038/s41386-023-01639-8. Epub 2023 Jul 3. PMID: 37400565; PMCID: PMC10579237.

Michael C. Anderson

Mentor: Thomas A. Blanpied, PhD

Metzbower SR, Levy AD, Dharmasri PA, Anderson MC, Blanpied TA. Distinct SAP102 and PSD-95 Nano-organization Defines Multiple Types of Synaptic Scaffold Protein Domains at Single Synapses. J Neurosci. 2024 Jun 26;44(26):e1715232024. doi: 10.1523/JNEUROSCI.1715-23.2024. PMID: 38777601; PMCID: PMC11211720.

Dharmasri PA, DeMarco EM, Anderson MC, Levy AD, Blanpied TA. Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95. bioRxiv [Preprint]. 2024 Jan 12:2024.01.12.574705. doi: 10.1101/2024.01.12.574705. PMID: 38260705; PMCID: PMC10802569.

Anderson MC, Levy AD, Dharmasri PA, Metzbower SR, Blanpied TA. Trans-synaptic molecular context of NMDA receptor nanodomains. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573055. doi: 10.1101/2023.12.22.573055. PMID: 38187545; PMCID: PMC10769418.

Rachel Cundiff-O'Sullivan

Mentor: Luana Colloca, MD, PhD, MS

Sheers NL, O'Sullivan R, Howard ME, Berlowitz DJ. The role of lung volume recruitment therapy in neuromuscular disease: a narrative review. Front Rehabil Sci. 2023 Jul 26;4:1164628. doi: 10.3389/fresc.2023.1164628. PMID: 37565183; PMCID: PMC10410160.

Cundiff-O'Sullivan RL, Wang Y, Thomas S, Zhu S, Campbell CM, Colloca L. Individual Dimensions of Pain Catastrophizing Do Not Mediate the Effect of Sociodemographic and Psychological Factors on Chronic Orofacial Pain Severity, Interference, and Jaw Limitation: A Structural Equation Modeling Approach. J Pain. 2023 Sep;24(9):1617-1632. doi: 10.1016/j.jpain.2023.04.010. Epub 2023 Apr 28. PMID: 37121497; PMCID: PMC10528356.

Emily M. DeMarco

Mentor: Thomas A. Blanpied, PhD

Dharmasri PA, DeMarco EM, Anderson MC, Levy AD, Blanpied TA. Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95. bioRxiv [Preprint]. 2024 Jan 12:2024.01.12.574705. doi: 10.1101/2024.01.12.574705. PMID: 38260705; PMCID: PMC10802569.

Keighron JD, Bonaventura J, Li Y, Yang JW, DeMarco EM, Hersey M, Cao J, Sandtner W, Michaelides M, Sitte HH, Newman AH, Tanda G. Interactions of calmodulin kinase II with the dopamine transporter facilitate cocaine-induced enhancement of evoked dopamine release. Transl Psychiatry. 2023 Jun 13;13(1):202. doi: 10.1038/s41398-023-02493-4. PMID: 37311803; PMCID: PMC10264427.

Poorna A. Dharmasri

Mentor: Thomas A. Blanpied, PhD

Metzbower SR, Levy AD, Dharmasri PA, Anderson MC, Blanpied TA. Distinct SAP102 and PSD-95 Nano-organization Defines Multiple Types of Synaptic Scaffold Protein Domains at Single Synapses. J Neurosci. 2024 Jun 26;44(26):e1715232024. doi: 10.1523/JNEUROSCI.1715-23.2024. PMID: 38777601; PMCID: PMC11211720.

Dharmasri PA, Levy AD, Blanpied TA. Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2315379121. doi: 10.1073/pnas.2315379121. Epub 2024 Apr 16. PMID: 38625946; PMCID: PMC11047112.

Dharmasri PA, DeMarco EM, Anderson MC, Levy AD, Blanpied TA. Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95. bioRxiv [Preprint]. 2024 Jan 12:2024.01.12.574705. doi: 10.1101/2024.01.12.574705. PMID: 38260705; PMCID: PMC10802569.

Anderson MC, Levy AD, Dharmasri PA, Metzbower SR, Blanpied TA. Trans-synaptic molecular context of NMDA receptor nanodomains. bioRxiv [Preprint]. 2023 Dec 23:2023.12.22.573055. doi: 10.1101/2023.12.22.573055. PMID: 38187545; PMCID: PMC10769418.

Emperador-Melero J, Andersen JW, Metzbower SR, Levy AD, Dharmasri PA, de Nola G, Blanpied TA, Kaeser PS. Molecular definition of distinct active zone protein machineries for Ca²⁺ channel clustering and synaptic vesicle priming. bioRxiv [Preprint]. 2023 Oct 30:2023.10.27.564439. doi: 10.1101/2023.10.27.564439. PMID: 37961089; PMCID: PMC10634917.

Soad M. Elziny

Mentor: Peter B. Crino, MD, PhD

Elziny S, Sran S, Yoon H, Corrigan RR, Page J, Ringland A, Lanier A, Lapidus S, Foreman J, Heinzen EL, Iffland P, Crino PB, Bedrosian TA. Loss of Slc35a2 alters development of the mouse cerebral cortex. Neurosci Lett. 2024 Jun 21:137881. doi: 10.1016/j.neulet.2024.137881. Epub ahead of print. PMID: 38909838.

Elziny S, Crino PB, Winawer M. SLC35A2 somatic variants in drug resistant epilepsy: FCD and MOGHE. Neurobiol Dis. 2023 Oct 15;187:106299. doi: 10.1016/j.nbd.2023.106299. Epub 2023 Sep 20. PMID: 37739137; PMCID: PMC10994450.

Elziny S, Crino PB. Vascularization in mTOR Mouse Mutants: An Effort Not in Vein. eNeuro. 2023 Jul 21;10(7):ENEURO.0122-23.2023. doi: 10.1523/ENEURO.0122-23.2023. PMID: 37479502; PMCID: PMC10368145.

Andrew J. Furman

Mentor: David A. Seminowicz, PhD

Mazaheri A, Furman AJ, Seminowicz DA. Fear and pain slow the brain. Pain. 2023 Oct 26:10.1097/j.pain.0000000000003099. doi: 10.1097/j.pain.0000000000003099. Epub ahead of print. PMID: 38112650; PMCID: PMC11045659.

Catherine W. Haga

Mentor: Asaf Keller, PhD

Olusakin J, Kumar G, Basu M, Calarco CA, Fox ME, Alipio JB, Haga C, Turner MD, Keller A, Ament SA, Lobo MK. Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice. Neuropsychopharmacology. 2023 Nov;48(12):1724-1734. doi: 10.1038/s41386-023-01639-8. Epub 2023 Jul 3. PMID: 37400565; PMCID: PMC10579237.

John W. Hussey

Mentor: Ivy E. Dick, PhD

Hussey JW, Limpitikul WB, Dick IE. Calmodulin Mutations in Human Disease. Channels (Austin). 2023 Dec;17(1):2165278. doi: 10.1080/19336950.2023.2165278. PMID: 36629534; PMCID: PMC9839377.

Herold KG, Hussey JW, Dick IE. CACNA1C-Related Channelopathies. Handb Exp Pharmacol. 2023;279:159-181. doi: 10.1007/164_2022_624. PMID: 36598608; PMCID: PMC10576998.

Niaz Z. Khan

Mentor: Alan I. Faden, MD

Henry RJ, Barrett JP, Vaida M, Khan NZ, Makarevich O, Ritzel RM, Faden AI, Stoica BA. Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction. J Neuroinflammation. 2024 Apr 29;21(1):113. doi: 10.1186/s12974-024-03107-6. PMID: 38685031; PMCID: PMC11058055.

Ritzel RM, Li Y, Jiao Y, Doran SJ, Khan N, Henry RJ, Brunner K, Loane DJ, Faden AI, Szeto GL, Wu J. Bi-directional neuro-immune dysfunction after chronic experimental brain injury. J Neuroinflammation. 2024 Apr 5;21(1):83. doi: 10.1186/s12974-024-03082-y. PMID: 38581043; PMCID: PMC10996305.

Ritzel RM, Li Y, Jiao Y, Doran SJ, Khan N, Henry RJ, Brunner K, Loane DJ, Faden AI, Szeto GL, Wu J. The brain-bone marrow axis and its implications for chronic traumatic brain injury. Res Sq [Preprint]. 2023 Oct 6:rs.3.rs-3356007. doi: 10.21203/rs.3.rs-3356007/v1. PMID: 37790560; PMCID: PMC10543403.

Li Y, Khan N, Ritzel RM, Lei Z, Allen S, Faden AI, Wu J. Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain. J Neuroinflammation. 2023 Aug 31;20(1):197. doi: 10.1186/s12974-023-02881-z. PMID: 37653491; PMCID: PMC10469550.

Saovleak Khim

Mentor: Steffen B.E. Wolff, PhD

Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos A. Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses. Biol Psychiatry. 2023 Dec 27:S0006-3223(23)01799-7. doi: 10.1016/j.biopsych.2023.12.020. Epub ahead of print. PMID: 38154503; PMCID: PMC11209832.

Richardson RR, Steyert M, Khim SN, Crutcher GW, Brandenburg C, Robertson CD, Romanowski AJ, Inen J, Altas B, Poulopoulos A. Enhancing Precision and Efficiency of Cas9-Mediated Knockin Through Combinatorial Fusions of DNA Repair Proteins. CRISPR J. 2023 Oct;6(5):447-461. doi: 10.1089/crispr.2023.0036. Epub 2023 Sep 15. PMID: 37713292; PMCID: PMC10611978.

Alex D. Klausing

Mentor: Robert Schwarcz, PhD

Klausing AD, Fukuwatari T, DeAngeli N, Bucci DJ, Schwarcz R. Adrenalectomy exacerbates stress-induced impairment in fear discrimination: A causal role for kynurenic acid? Biochem Pharmacol. 2024 Jun 7:116350. doi: 10.1016/j.bcp.2024.116350. Epub ahead of print. PMID: 38852644.

Gautam Kumar

Mentor: Mary Kay Lobo, PhD

Calarco CA, Keppetipola SM, Kumar G, Shipper AG, Lobo MK. Whole blood mitochondrial copy number in clinical populations with mood disorders: A meta-analysis: Blood mitochondrial copy number and mood disorders. Psychiatry Res. 2024 Jan;331:115662. doi: 10.1016/j.psychres.2023.115662. Epub 2023 Dec 10. PMID: 38118327.

Olusakin J, Kumar G, Basu M, Calarco CA, Fox ME, Alipio JB, Haga C, Turner MD, Keller A, Ament SA, Lobo MK. Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice. Neuropsychopharmacology. 2023 Nov;48(12):1724-1734. doi: 10.1038/s41386-023-01639-8. Epub 2023 Jul 3. PMID: 37400565; PMCID: PMC10579237.

Rebecca M. Lorsung

Mentor: Asaf Keller, PhD

Smith JA, Ji Y, Lorsung R, Breault MS, Koenig J, Cramer N, Masri R, Keller A. Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice. J Neurosci. 2023 Aug 2;43(31):5656-5667. doi: 10.1523/JNEUROSCI.0587-23.2023. Epub 2023 Jul 14. PMID: 37451980; PMCID: PMC10401640.

Miriam S. Menken

Mentor: Linda Chang, MD

Rodriguez Rivera PJ, Liang H, Isaiah A, Cloak CC, Menken MS, Ryan MC, Ernst T, Chang L. Prenatal tobacco exposure on brain morphometry partially mediated poor cognitive performance in preadolescent children. NeuroImmune Pharm Ther. 2023 Jul 13;2(4):375-386. doi: 10.1515/nipt-2023-0013. PMID: 38058999; PMCID: PMC10696570.

Kristen R. Montgomery

Mentor: Nicholas H. Carbonetti, PhD

Cissé YM, Montgomery KR, Zierden HC, Hill EM, Kane PJ, Huang W, Kane MA, Bale TL. Maternal preconception stress produces sex-specific effects at the maternal:fetal interface to impact offspring development and phenotypic outcomes†. Biol Reprod. 2024 Feb 10;110(2):339-354. doi: 10.1093/biolre/ioad156. PMID: 37971364; PMCID: PMC10873277.

Montgomery KR, Bridi MS, Folts LM, Marx-Rattner R, Zierden HC, Wulff AB, Kodjo EA, Thompson SM, Bale TL. Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects. Neuropsychopharmacology. 2024 Jan;49(2):443-454. doi: 10.1038/s41386-023-01739-5. Epub 2023 Oct 13. PMID: 37833589; PMCID: PMC10724197.

Mitchell B. Moyer

Mentor: J. Marc Simard, MD, PhD

McAfee D, Moyer M, Queen J, Mortazavi A, Boddeti U, Bachani M, Zaghloul K, Ksendzovsky A. Differential metabolic alterations in IDH1 mutant vs. wildtype glioma cells promote epileptogenesis through distinctive mechanisms. Front Cell Neurosci. 2023 Nov 9;17:1288918. doi: 10.3389/fncel.2023.1288918. PMID: 38026690; PMCID: PMC10680369.

Shim B, Stokum JA, Moyer M, Tsymbalyuk N, Tsymbalyuk O, Keledjian K, Ivanova S, Tosun C, Gerzanich V, Simard JM. Canagliflozin, an Inhibitor of the Na⁺-Coupled D-Glucose Cotransporter, SGLT2, Inhibits Astrocyte Swelling and Brain Swelling in Cerebral Ischemia. Cells. 2023 Sep 6;12(18):2221. doi: 10.3390/cells12182221. PMID: 37759444; PMCID: PMC10527352.

Janell S. Payano Sosa

Mentor: David A. Seminowicz, PhD

Mathur VA, Payano Sosa JS, Keaser ML, Meiller TF, Seminowicz DA. The social context of burning mouth syndrome: an exploratory pilot study of stigma, discrimination, and pain. Pain Med. 2023 Nov 2;24(11):1213-1218. doi: 10.1093/pm/pnad078. PMID: 37314981; PMCID: PMC10628978.

Lace M. Riggs

Mentor: Todd D. Gould, MD

Riggs LM, Pereira EFR, Thompson SM, Gould TD. cAMP-dependent protein kinase signaling is required for (2R,6R)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission. J Neurophysiol. 2024 Jan 1;131(1):64-74. doi: 10.1152/jn.00326.2023. Epub 2023 Dec 5. PMID: 38050689.

Colin D. Robertson

Mentor: Alex Poulopolous, PhD

Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos A. Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses. Biol Psychiatry. 2023 Dec 27:S0006-3223(23)01799-7. doi: 10.1016/j.biopsych.2023.12.020. Epub ahead of print. PMID: 38154503; PMCID: PMC11209832.

Robertson CD, Davis P, Richardson RR, Iffland PH 2nd, Vieira DCO, Steyert M, McKeon PN, Romanowski AJ, Crutcher G, Jašarević E, Wolff SBE, Mathur BN, Crino PB, Bale TL, Dick IE, Poulopoulos A. Rapid modeling of an ultra-rare epilepsy variant in wild-type mice by in utero prime editing. bioRxiv [Preprint]. 2023 Dec 19:2023.12.06.570164. doi: 10.1101/2023.12.06.570164. PMID: 38106154; PMCID: PMC10723435.

Richardson RR, Steyert M, Khim SN, Crutcher GW, Brandenburg C, Robertson CD, Romanowski AJ, Inen J, Altas B, Poulopoulos A. Enhancing Precision and Efficiency of Cas9-Mediated Knockin Through Combinatorial Fusions of DNA Repair Proteins. CRISPR J. 2023 Oct;6(5):447-461. doi: 10.1089/crispr.2023.0036. Epub 2023 Sep 15. PMID: 37713292; PMCID: PMC10611978.

Pedro Rodriguez Rivera

Mentor: Linda Chang, MD, MS

Rodriguez Rivera PJ, Liang H, Isaiah A, Cloak CC, Menken MS, Ryan MC, Ernst T, Chang L. Prenatal tobacco exposure on brain morphometry partially mediated poor cognitive performance in preadolescent children. NeuroImmune Pharm Ther. 2023 Jul 13;2(4):375-386. doi: 10.1515/nipt-2023-0013. PMID: 38058999; PMCID: PMC10696570.

Meghann C. Ryan

Mentor: Linda Chang, MD, MS

Ernst T, Ryan MC, Liang HJ, Wang JP, Cunningham E, Saleh MG, Kottilil S, Chang L. Neuronal and Glial Metabolite Abnormalities in Participants With Persistent Neuropsychiatric Symptoms After COVID-19: A Brain Proton Magnetic Resonance Spectroscopy Study. J Infect Dis. 2023 Nov 28;228(11):1559-1570. doi: 10.1093/infdis/jiad309. PMID: 37540098; PMCID: PMC10681871.

Rodriguez Rivera PJ, Liang H, Isaiah A, Cloak CC, Menken MS, Ryan MC, Ernst T, Chang L. Prenatal tobacco exposure on brain morphometry partially mediated poor cognitive performance in preadolescent children. NeuroImmune Pharm Ther. 2023 Jul 13;2(4):375-386. doi: 10.1515/nipt-2023-0013. PMID: 38058999; PMCID: PMC10696570.

Kelson Shilling-Scrivo

Mentor: Joseph P. Kao, PhD

Bowen Z, Shilling-Scrivo K, Losert W, Kanold PO. Fractured columnar small-world functional network organization in volumes of L2/3 of mouse auditory cortex. PNAS Nexus. 2024 Feb 12;3(2):pgae074. doi: 10.1093/pnasnexus/pgae074. PMID: 38415223; PMCID: PMC10898513.

Mittelstadt JK, Shilling-Scrivo KV, Kanold PO. Long-term training alters response dynamics in the aging auditory cortex. Hear Res. 2024 Mar 15;444:108965. doi: 10.1016/j.heares.2024.108965. Epub 2024 Jan 28. PMID: 38364511; PMCID: PMC11186583.

Jesse A. Smith

Mentor: Asaf Keller, PhD

Smith JA, Ji Y, Lorsung R, Breault MS, Koenig J, Cramer N, Masri R, Keller A. Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice. J Neurosci. 2023 Aug 2;43(31):5656-5667. doi: 10.1523/JNEUROSCI.0587-23.2023. Epub 2023 Jul 14. PMID: 37451980; PMCID: PMC10401640.

Catherine A. Stapf

Mentor: Donna J. Calu, PhD

Stapf CA, Keefer SE, McInerney JM, Calu DJ. Sex specific effects of dorsomedial striatal cannabinoid receptor-1 signaling on Pavlovian outcome devaluation. bioRxiv [Preprint]. 2024 May 1:2024.05.01.592059. doi: 10.1101/2024.05.01.592059. PMID: 38746352; PMCID: PMC11092566.

Brent W. Stewart

Mentor: David A. Seminowicz, PhD

Stewart BW, Keaser ML, Lee H, Margerison SM, Cormie MA, Moayedi M, Lindquist MA, Chen S, Mathur BN, Seminowicz DA. Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain. Curr Biol. 2024 May 6;34(9):1953-1966.e6. doi: 10.1016/j.cub.2024.03.021. Epub 2024 Apr 12. PMID: 38614082.

Lakota Watson

Mentor: Luana Colloca, PhD, MD

Raghuraman N, White JN, Watson L, Belleï-Rodriguez CÉ, Shafir R, Wang Y, Colloca L. Neuropsychological mechanisms of observational learning in human placebo effects. Psychopharmacology (Berl). 2024 May 14. doi: 10.1007/s00213-024-06608-7. Epub ahead of print. PMID: 38743108.

Jewel N. White

Mentor: Luana Colloca, PhD, MD

Raghuraman N, White JN, Watson L, Belleï-Rodriguez CÉ, Shafir R, Wang Y, Colloca L. Neuropsychological mechanisms of observational learning in human placebo effects. Psychopharmacology (Berl). 2024 May 14. doi: 10.1007/s00213-024-06608-7. Epub ahead of print. PMID: 38743108.

Colloca L, Mocci E, Wang Y, Massalee R, Chen S, White J, Johnson K, Patron Fidalgo GM, Wilson GM, Goldman D, Dorsey SG. Transcriptomic Profiles Associated with Experimental Placebo Effects in Chronic Pain. Clin Pharmacol Ther. 2024 Aug;116(2):380-389. doi: 10.1002/cpt.3286. Epub 2024 May 6. PMID: 38711244; PMCID: PMC11251865.

Julia R. Whitten

Mentor: Alex Poulopolous, PhD

Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos A. Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses. Biol Psychiatry. 2023 Dec 27:S0006-3223(23)01799-7. doi: 10.1016/j.biopsych.2023.12.020. Epub ahead of print. PMID: 38154503; PMCID: PMC11209832.

Andreas B. Wulff

Mentor: Scott M. Thompson, PhD

Montgomery KR, Bridi MS, Folts LM, Marx-Rattner R, Zierden HC, Wulff AB, Kodjo EA, Thompson SM, Bale TL. Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects. Neuropsychopharmacology. 2024 Jan;49(2):443-454. doi: 10.1038/s41386-023-01739-5. Epub 2023 Oct 13. PMID: 37833589; PMCID: PMC10724197.

Wulff AB, Cooper P, Kodjo E, Abel E, Thompson SM. How Sucrose Preference Is Gained and Lost: An In-Depth Analysis of Drinking Behavior during the Sucrose Preference Test in Mice. eNeuro. 2023 Sep 28;10(9):ENEURO.0195-23.2023. doi: 10.1523/ENEURO.0195-23.2023. PMID: 37699705; PMCID: PMC10540674.

 

Nesreen Alissa

Mentor: Kelly P. Westlake, PhD, MSc, PT

Jeon W, Ramadan A, Whitall J, Alissa N, Westlake K. Age-related differences in lower limb muscle activation patterns and balance control strategies while walking over a compliant surface. Sci Rep. 2023 Oct 2;13(1):16555. doi: 10.1038/s41598-023-43728-0. PMID: 37783842; PMCID: PMC10545684.

Alissa N, Rehan R, Al-Sharman A, Latrous M, Aburub AS, El-Salem K, Morris L, Khalil H. Cognitive status and sleep quality can explain the fear of falling and fall history in people with Parkinson's disease. Int J Rehabil Res. 2023 Dec 1;46(4):338-343. doi: 10.1097/MRR.0000000000000596. Epub 2023 Aug 15. PMID: 37581294.

Kathleen Dondero

Mentor: Odessa R. Addison, DPT, PhD

Dondero K, Friedman B, Rekant J, Landers-Ramos R, Addison O. The effects of myosteatosis on skeletal muscle function in older adults. Physiol Rep. 2024 May;12(9):e16042. doi: 10.14814/phy2.16042. PMID: 38705872; PMCID: PMC11070439.

Landers-Ramos RQ, Dondero K, Imery I, Reveille N, Zabriskie HA, Dobrosielski DA. Influence of cardiorespiratory fitness and body composition on resting and post-exercise indices of vascular health in young adults. Sports Med Health Sci. 2023 Nov 21;6(1):54-62. doi: 10.1016/j.smhs.2023.11.003. PMID: 38463670; PMCID: PMC10918352.

Simon Ho

Mentor: Victoria G. Marchese, PhD, PT

Rock K, Ho S, Gray VL, Addison O, York T, Keegan Wells D, DeLuca H, Marchese V. Muscle Properties, Gross Motor Performance, and Quality of Life in Children With Sickle Cell Disease. Pediatr Phys Ther. 2023 Oct 1;35(4):450-456. doi: 10.1097/PEP.0000000000001037. Epub 2023 Sep 2. PMID: 37656986.

Sarah M. Margerison

Mentors: David A. Seminowicz, PhD and Kelly P. Westlake, PhD, MSc, PT

do Espírito-Santo RF, Margerison SM, Zhang Y, Pak J, Ro JY, Da Silva JT. Age- and Sex-Dependent Effects of Moderate Exercise on Endogenous Pain Inhibition in Rats. Biomedicines. 2024 May 18;12(5):1122. doi: 10.3390/biomedicines12051122. PMID: 38791084; PMCID: PMC11117727.

Stewart BW, Keaser ML, Lee H, Margerison SM, Cormie MA, Moayedi M, Lindquist MA, Chen S, Mathur BN, Seminowicz DA. Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain. Curr Biol. 2024 May 6;34(9):1953-1966.e6. doi: 10.1016/j.cub.2024.03.021. Epub 2024 Apr 12. PMID: 38614082.

Emily G. McCarthy

Mentor: Victoria G. Marchese, PhD, PT

McCarthy E, Marchese VG, Shipper AG, Rock K, Felter C. Identifying causes of balance impairment and exploring sensory contributions to balance in pediatric oncology: A scoping review. Crit Rev Oncol Hematol. 2024 Jun 22;201:104425. doi: 10.1016/j.critrevonc.2024.104425. Epub ahead of print. PMID: 38909876.

McCarthy E. A Review of Late Effects in Pediatric Cancer: Implications for Rehabilitation. Rehabil Oncol. 2023 Oct;41(4):215-218. doi: 10.1097/01.reo.0000000000000351. Epub 2023 Oct 2. PMID: 38524881; PMCID: PMC10957136.

Rachel E. Reoli

Mentor: Jill Whitall, PhD

Reoli R, Therrien A, Millar J, Hill N, Varghese R, Roemmich R, Whitall J, Bastian A, Keller J. The Scale for Assessment and Rating of Ataxia Is Reliable and Valid in the Telehealth Setting for Patients With Cerebellar Ataxia. Phys Ther. 2024 Mar 1;104(3):pzad166. doi: 10.1093/ptj/pzad166. PMID: 38051602; PMCID: PMC10921830.

Kelly Rock

Mentor: Victoria G. Marchese, PhD, PT

McCarthy E, Marchese VG, Shipper AG, Rock K, Felter C. Identifying causes of balance impairment and exploring sensory contributions to balance in pediatric oncology: A scoping review. Crit Rev Oncol Hematol. 2024 Jun 22;201:104425. doi: 10.1016/j.critrevonc.2024.104425. Epub ahead of print. PMID: 38909876.

Skiba MB, Wells SJ, Brick R, Tanner L, Rock K, Marchese V, Khalil N, Raches D, Thomas K, Krause KJ, Swartz MC. A Systematic Review of Telehealth-Based Pediatric Cancer Rehabilitation Interventions on Disability. Telemed J E Health. 2024 Apr;30(4):901-918. doi: 10.1089/tmj.2023.0224. Epub 2023 Oct 23. PMID: 38010811; PMCID: PMC11040188.

Rock K, Ho S, Gray VL, Addison O, York T, Keegan Wells D, DeLuca H, Marchese V. Muscle Properties, Gross Motor Performance, and Quality of Life in Children With Sickle Cell Disease. Pediatr Phys Ther. 2023 Oct 1;35(4):450-456. doi: 10.1097/PEP.0000000000001037. Epub 2023 Sep 2. PMID: 37656986.

Kylie Tomlin

Mentor: Kelly P. Westlake, PhD, MSc, PT

Tomlin KB, Johnson BP, Westlake KP. Age-Related Differences in Motor Skill Transfer with Brief Memory Reactivation. Brain Sci. 2024 Jan 9;14(1):65. doi: 10.3390/brainsci14010065. PMID: 38248280; PMCID: PMC10813682.